Consulta: subjectFacets:"Malaria"
Registros recuperados: 66
Data/hora: 09/06/2024 08:44:03

Independent Associations of Maternal Education and Household Wealth with Malaria Risk in Children
Provedor de dados: 7
Despite evidence that they play similar but independent roles, maternal education and household wealth are usually conflated in studies of the effects of socioeconomic status (SES) on malaria risk. Demographic and Health Survey and Malaria Indicator Survey data from nine countries in sub-Saharan Africa were used to explore the relationship of malaria parasitemia in children with SES factors at individual and cluster scales, controlling for urban/rural residence and other important covariates. In multilevel logistic regression modeling, completion of six years of maternal schooling was associated with significantly lower odds of infection in children (OR = 0.73), as was a household wealth index at the 40th percentile compared to the lowest percentile (OR =...
Tipo: Peer-Reviewed Reports
Palavras-chave: Demographic and Health Survey; DHS; Malaria; Malaria Indicator Survey; Maternal education; MIS; Multilevel modeling; Socioeconomic factors.
Ano: 2014

Aspectos atuais da distribuição geográfica de Anopheles (Kerteszia) cruzii Dyar &amp;amp; Knab, 1908 no estado do Espírito Santo, Brasil
Provedor de dados: 71
Autores: Rezende,Helder Ricas; Cerutti Junior,Crispim; Santos,Claudiney Biral dos.
Anopheles cruzii was registered in Espírito Santo state both in 1957 and 1968. Our study provides additional evidence of its presence, including municipalities that were non mentioned before. Anopheles captures undertaken between 1998 and 2003 pointed out a distribution restricted to the forested outskirts of the mountains in the highland area of the state. Its epidemiological role is suggested by the simultaneous presence of malaria cases in the same municipalities.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Anopheles cruzii; Malaria; Geographical distribution; Espírito Santo; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0328-03812005000100011

Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon
Provedor de dados: 74
Autores: Fontes,Aparecida Maria; Kashima,Simone; Bonfim-Silva,Ricardo; Azevedo,Rochele; Abraham,Kuruvilla Joseph; Albuquerque,Sérgio Roberto Lopes; Bordin,José Orlando; Langhi Júnior,Dante Mário; Covas,Dimas Tadeu.
Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Brazilian Amazon population; CR1 haplotypes; Knops blood group polymorphism; Malaria.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400002

Resurgence risk for malaria, and the characterization of a recent outbreak in an Amazonian border area between French Guiana and Brazil
Provedor de dados: 5
Autores: Mosnier, Emilie; Dusfour, Isabelle; Lacour, Guillaume; Saldanha, Raphael; Guidez, Amandine; Gomes, Margarete S.; Sanna, Alice; Epelboin, Yanouk; Restrepo, Johana; Davy, Damien; Demar, Magalie; Djossou, Félix; Douine, Maylis; Ardillon, Vanessa; Nacher, Mathieu; Musset, Lise; Roux, Emmanuel.
Background In 2017, inhabitants along the border between French Guiana and Brazil were affected by a malaria outbreak primarily due to Plasmodium vivax (Pv). While malaria cases have steadily declined between 2005 and 2016 in this Amazonian region, a resurgence was observed in 2017. Methods Two investigations were performed according to different spatial scales and information details: (1) a local study on the French Guiana border, which enabled a thorough investigation of malaria cases treated at a local village health center and the entomological circumstances in the most affected neighborhood, and (2) a regional and cross-border study, which enabled exploration of the regional spatiotemporal epidemic dynamic. Number and location of malaria cases were...
Tipo: Text
Palavras-chave: Plasmodium vivax; Anopheles darlingi; French Guiana; Brazil; Transnational; Outbreak investigation; Indigenous south Americans; Malaria; Amazonia.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00632/74387/74081.pdf

Alkoxyamines Designed as Potential Drugs against Plasmodium and Schistosoma Parasites
Provedor de dados: 5
Autores: Reyser, Thibaud; To, Tung H.; Egwu, Chinedu; Paloque, Lucie; Nguyen, Michel; Hamouy, Alexandre; Stigliani, Jean-luc; Bijani, Christian; Augereau, Jean-michel; Joly, Jean-patrick; Portela, Julien; Havot, Jeffrey; Marque, Sylvain R. A.; Boissier, Jérôme; Robert, Anne; Benoit-vical, Françoise; Audran, Gérard.
Malaria and schistosomiasis are major infectious causes of morbidity and mortality in the tropical and sub-tropical areas. Due to the widespread drug resistance of the parasites, the availability of new efficient and affordable drugs for these endemic pathologies is now a critical public health issue. In this study, we report the design, the synthesis and the preliminary biological evaluation of a series of alkoxyamine derivatives as potential drugs against Plasmodium and Schistosoma parasites. The compounds (RS/SR)-2F, (RR/SS)-2F, and 8F, having IC50 values in nanomolar range against drug-resistant P. falciparum strains, but also five other alkoxyamines, inducing the death of all adult worms of S. mansoni in only 1 h, can be considered as interesting...
Tipo: Text
Palavras-chave: Alkoxyamine; Alkylation; Heme; Malaria; Radical chemistry; Schistosomiasis.
Ano: 2020
URL: https://archimer.ifremer.fr/doc/00648/76024/76920.pdf

Insecticidal activity of Leptodactylus knudseni andPhyllomedusa vaillantii crude skin secretions against the mosquitoes Anopheles darlingi andAedes aegypti
Provedor de dados: 80
Autores: Trindade,Frances TT; Soares,Ângela A; Moura,Andréa A de; Rego,Tiago B; Soares,Andreimar M; Stábeli,Rodrigo G; Calderon,Leonardo A; Almeida e Silva,Alexandre de.
Background Mosquitoes are important vectors of several diseases, including malaria and dengue, and control measures are mostly performed using chemical insecticides. Unfortunately, mosquito resistance to commonly applied insecticides is widespread. Therefore, a prospection for new molecules with insecticidal activity based on Amazon biodiversity using the anuransLeptodactylus knudseni andPhyllomedusa vaillantii was performed against the mosquito speciesAnopheles darlingi and Aedes aegypti.Methods The granular secretion from anuran skin was obtained by manual stimulation, and lethal concentrations (LCs) for larvicidal and adulticidal tests were calculated using concentrations from 1-100 ppm. The skin secretions from the anuran species tested caused...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Vector control; Anuran amphibians; Dengue; Malaria.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992014000200334

Physiological age and longevity of Anopheles (Kerteszia) cruzii Dyar Knab (Diptera: Culicidae) in the Atlantic Forest of Southern Brazil
Provedor de dados: 82
Autores: Dalla Bona,Ana C; Navarro-Silva,Mário A.
We analyzed the reproductive status, ovarian development, daily survival rate, and length of the gonotrophic cycle in females of Anopheles ( Kerteszia ) cruzii Dyar &amp;amp; Knab, to determine how these factors influence the risk of malaria transmission in the coastal region of the state of Paraná, southern Brazil. In the Palmito State Forest, Paranaguá, females were captured at dawn and dusk by aspiration, bimonthly from December 2006 through March 2007. A total of 2,268 females were captured, of which 454 were dissected. Of these, 48% were parous, 50% not reproductive, 73% in Christopher and Mer stages I and II, 23% in stages III to V, 55% nulliparous, 14% uniparous, and 11% had blood in their midgut. Daily survival was 0.24 ± 0.03 overall, 0.51 ± 0.04...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Parity; Daily survival rate; Ovarian development; Malaria.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000200021

Mosquito Anthropophily: implications on malaria transmission in the northern Brazilian Amazon
Provedor de dados: 82
Autores: Barros,Fábio S M; Honório,Nildimar A; Arruda,Mércia E.
Seasonal variation of adults and larvae of anophelines was studied during 2003 and 2004 in Roraima State, located in the Northern region of Brazilian Amazon. Species diversity increased with distance of capture to human dwellings. Greater diversity was found in extradomiciliary collections than in peridomiciliary or intradomiciliary. A significant association between Anopheles darlingi Root and An. albitarsis (s.l.) Arribálzaga (Diptera: Culicidae) breeding sites and the proximity to human dwellings was observed. Malaria Sporozoite Antigen Panel Assay (VectestTM Malaria) indicated An. albitarsis s.l. as one of the local vectors in the studied area. In this study, an index to describe the anthropophilic behavior of each anopheline species is proposed.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anopheles darlingi; Anopheles albitarsis; Anthropophily; Malaria; Brazil.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000600029

Transgenic mosquitoes for malaria control: progresses and challenges
Provedor de dados: 82
Autores: Moreira,Luciano A.; Jacobs-Lorena,Marcelo.
Malaria kills millions of people every year and the current strategies to control the disease, such as insecticides and drugs have not been completely efficient. Because of that, novel means to fight against malaria are of utmost importance. Advances in the study of the mosquito vector and its interactions with the malaria parasite made scientists think that it is possible to genetically manipulate the mosquitoes to make them inefficient vectors. Here we review the advances on the introduction of foreign genes into the mosquito germ line, the characterization of tissue-specific promoters, the identification of gene products that block development of the parasite in the mosquito, and we discuss the recent generation of transgenic mosquitoes impaired for...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Transgenesis; Transmission blocking; Plasmodium.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2003000400001

Mitochondrial DNA divergence between wild and laboratory populations of Anopheles albimanus Wiedemann (Diptera: Culicidae)
Provedor de dados: 82
Autores: Arias,Lida; Bejarano,Eduar E.; Márquez,Edna; Moncada,John; Vélez,Iván; Uribe,Sandra.
Studies of insect vectors may be facilitated by using laboratory colonies. However, it has been suggested that the colony insects are not representative of natural populations, sometimes yealding to erroneous interpretations of the intraspecific genetic variation between the individuals. In the present study the variability of the mitochondrial gene cytochrome b was evaluated among a closed laboratory colony of Anopheles albimanus that was founded 20 years ago and the field population from which it was derived. The analyses revealed the presence of five and three nucleotide haplotypes in the wild and colony populations, respectively. Wild individuals presented greater variability than those of the colony based on the number of polymorphic sites, haplotype...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Genetic variability; Malaria; Mosquito.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2005000300020

Proteinuria in Malaria Patients in Minna, Nigeria
Provedor de dados: 19
Autores: Ogbadoyi, Emmanuel O.; Tembeng, Fon Charles.
Palavras-chave: Plasmodia; Proteinuria; Malaria; Renal failure.
Ano: 1999
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/316

Candidacy of liver stage antigen-1 for Plasmodium falciparum vaccine development
Provedor de dados: 19
Autores: Taylor-Robinson, Andrew W.; Heal, Karen G.
Malaria is the world's most important parasitic disease, imposing a massive health burden on people living in the tropics, often in the poorest countries. The vast majority of deaths in humans from malaria are caused by one species of the hemoprotozoan, Plasmodium falciparum., against which effective control measures are urgently needed. The global situation has deteriorated in recent times due to increased resistance of the anopheline mosquitoes that transmit P. falciparum to insecticides, and of the parasites themselves to drug therapy. An efficacious and cost-effective vaccine against this parasite is considered a public health priority. A vaccine that targets pre-erythrocytic parasites in the liver could potentially prevent clinical disease by blocking...
Palavras-chave: Malaria; Plasmodium falciparum; Liver stage; Vaccine; Cellular immunity.
Ano: 2001
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/133

Studies on Drug Metabolizing Enzymes During Arteether Treatment of Plasmodium yoelii nigeriensis Infected Mice Cerebral Microvessels
Provedor de dados: 19
Autores: Agrawal, Anju.
Palavras-chave: Plasmodium yoelii; Drug metabolizing enzymes; Microvessels; Malaria.
Ano: 2000
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/335

Hepatic Oxidative Stress and Antioxidant Defenses During Chloroquine-Resistant and Sensitive Plasmodium berghei Infecton in Mice
Provedor de dados: 19
Autores: Srivastava, Pratima; Pandey, Vikaash C.
Palavras-chave: Malaria; Plasmodium berghei; Chloroquine-resistant; Chloroquine-sensitive; Oxidative damage; Superoxide scavenging system.
Ano: 1996
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/245

Probucol dramatically enhances dihydroartemisinin effect in murine malaria
Provedor de dados: 19
Autores: Kume, Aiko; Dang Trinh Minh Anh; Shichiri, Mototada; Ishida, Noriko; Suzuki, Hiroshi.
Background: Artemisinin-based combination therapy (ACT) has been adopted as national policy for the first-line treatment in large number of malaria-endemic regions. However, artemisinin-resistant parasites have emerged and are spreading, with slow-cleaning parasites being reported in patients treated with ACT. It means that more parasites are exposed to the partner drug alone and the risk of developing resistant parasites against the partner drug is increasing. Therefore, the development of a new method to enhance the effect of artemisinin is required. In this study, the potential effect of probucol as a combination drug of dihydroartemisinin (DHA), an artemisinin derivative, was examined. Methods: C57BL/6 J mice infected with Plasmodium yoelii XL-17 were...
Palavras-chave: C57BL/6 J mice; Dihydroartemisinin; Malaria; Oxidative stress; Probucol; Plasmodium yoelii XL-17; Vitamin E.
Ano: 2016
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4436

Vitamin C Deficiency Fails to Protect Mice from Malaria
Provedor de dados: 19
Autores: HERBAS, Maria Shirley; SUZUKI, Hiroshi; 鈴木, 宏志.
Nutritional deficiencies are frequent in malaria-endemic areas. It seems that micronutrient antioxidants play an important role in malaria parasite’s proliferation. Thus, the effect of vitamin C deficiency on malaria infection was examined in mice. When vitamin C deficient mice, L-gulono-γ-lactone oxidase gene knockout mice which are unable to synthesize ascorbic acid, were infected with a lethal dose of Plasmodium berghei NK65-infected red blood cells, the knockout mice showed similar parasitemia kinetics and survival rates as wild-type mice. The results indicate that deficiency of vitamin C might not affect the development of the malaria parasite in mice.
Palavras-chave: Free radical; Malaria; Vitamin C.
Ano: 2010
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3016

RHOPTRY PROTEINS OF PLASMODIUM SPECIES
Provedor de dados: 19
Autores: Sam-Yellowe, Tobili Y.; Fujioka, Hisashi.
Palavras-chave: Apical complex organelles; Erythrocyte binding proteins; Erythrocyte invasion; Malaria; Micronemes; Plasmodium berghei; Plasmodium chabaudi; Plasmodium falciparum; Plasmodium yoelii; Rhoptries.
Ano: 2000
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/336

Epitopic Specificity of the Human Immune Response to the Invariant Region of a Polymorphic Plasmodium faciparum Merozoite Surface Antigen
Provedor de dados: 19
Autores: Rzepczyk, C. M.; Anderson, K. L.; Crurshes, P. A.; Baxter, E. P.; Kere, N.; Irving, D.; Dyer, S.; Jones, G. L.
Merozoite surface antigen 2 (MSA2) is a Plasmodium falciparum vaccine candidate. Antibody responses to MSA2 in Melanesians naturally exposed to P. falciparum were investigated by ELISA using the recombinant MSA2 protein known as Ag 1609 and 65 overlapping synthetic peptides spanning predominantly the conserved N and C terminal regions of MSA2. Significant differences were obtained between control and malaria exposed subjects in the ability of sera to bind to Ag 1609. The median absorbance obtained with control sera was 0.36 whereas that obtained with sera from malaria exposed subjects was 1.8. The sera of ninety-five percent of malaria exposed subjects reacted significantly with Ag 1609. The percentage reactivity of the control sera with Ag 1609 was 39%....
Palavras-chave: Malaria; Merozoite surface antigen 2 (MSA2); Antibody.
Ano: 1992
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/170

Fishing and poverty levels around Lake Victoria (Kenya)
Provedor de dados: 20
Autores: Abila, R.O.; Omwega, R.N.; Lwenya, C.
Fishing is known to be one of the oldest occupations of mankind and in Lake Victoria (Kenya); it has been largely practiced at artisanal levels. Despite this, poverty amongst the fisher folk remains high. Why the fisher folk remain in perpetual poverty was the key research question for this study. Sampling was conducted on 12 landing beaches between June and August 2004. Data was obtained using survey questionnaires; personal interviews were made using open-ended questions and beach observations. Results from this study indicates that 179 fishers sampled earned an average income of Ksh. 107,063 each in a year with modal income of Ksh. 57,600 while in a day they earned an average income of Ksh. 518 each with modal income of Ksh. 200. Fishers perceived that...
Tipo: Proceedings Paper
Palavras-chave: Fishing; Artisanal fishing; Lake fisheries; Socioeconomic aspects; Fishery economics; Public health; Malaria; Fishery management; Pricing.
Ano: 2006
URL: http://hdl.handle.net/1834/1495

Transgenic tomato plants expressing the antigen gene PfCP-2.9 of Plasmodium falciparum
Provedor de dados: 86
Autores: Kantor,Mihail; Sestras,Radu; Chowdhury,Kamal.
The objective of this work was to obtain transgenic tomato plants expressing the PfCP-2.9 protein (a chimera of the antigens MSP1 and AMA1 of Plasmodium falciparum). Cotyledons of seven-day-old tomatoes, cultivar Summers, were transformed via Agrobacterium tumefaciens. Transgenic expression in the T0 plants was verified in the DNA extracted from fruits. PCR analysis was used to test the presence of the gene of interest in the T1 generation. Reverse transcriptase PCR provided evidence of gene expression at the RNA level, and Western blot analysis confirmed the presence of the protein of interest in the T1 plants. This is the first report of successful transformation with the expression of a malaria antigen (PfCP-2.9) in transgenic tomato plants from the T0...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Gene expression; Genetic transformation; Malaria; Plant-made vaccines.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-204X2013000100010

Agricultural efficiency, malaria incidence and health expenses among Ugandan farmers
Provedor de dados: 31
Autores: Ulimwengu,   John M.; Badiane,   Ousmane.
The importance of health in promoting economic development has been forcefully stated by the World Health Organization’s Commission on Macroeconomics and Health. In this paper, we look at the impact of own household health expenses on malaria incidence and ultimately on agricultural efficiency. We use a non-parametric method to estimate agricultural efficiency, therefore avoiding the issue of identification of the proper household agricultural production function. In addition the simar-wilson approach followed in this paper accounts for bias induced by serial correlation among farmers. A Tobit model with endogenous health production function is used to estimate the impact of malaria incidence on agricultural efficiency. Data come from the 2006 National...
Tipo: Conference Paper or Presentation
Palavras-chave: Malaria; Efficiency; Tobit; Health; Agriculture; Expenses; Household; Production; Agricultural and Food Policy; Health Economics and Policy; Productivity Analysis.
Ano: 2011
URL: http://purl.umn.edu/103839

Malaria and National Income: Examining a Two Way Causal Relationship
Provedor de dados: 31
Autores: Datta,   Saurabh; Reimer,   Jeffrey J.
Simple plots of data show that malaria has a negative correlation with national income per capita, whether looking across countries at a point in time, or looking at a single country over time.  Some countries have been able to move from an equilibrium characterized by low income and high malaria, to a new equilibrium with higher income and lower rates of malaria.  This study develops and estimates a simultaneous equations model to explain these changes.  We distinguish three potential causal chains: (a) the ability for decreases in malaria to increase income, (b) the ability for increases in income to reduce malaria (reverse causality), and (c) external factors that may lead to both higher income and lower malaria (incidental association).  We find that...
Tipo: Conference Paper or Presentation
Palavras-chave: Antipoverty; GDP; Health; Economic growth; Malaria; Simultaneous equations; Health Economics and Policy; International Development; Labor and Human Capital; I1; I3; O1; O2.
Ano: 2010
URL: http://purl.umn.edu/61179

ACT Now or Later: The Economics of Malaria Resistance
Provedor de dados: 31
Autores: Laxminarayan,   Ramanan.
In the past, malaria control efforts in sub-Saharan Africa have relied on a combination of vector control and effective treatment using chloroquine. With increasing resistance to chloroquine, attention has now turned to alternative treatment strategies to replace this failing drug. Although there are strong theoretical arguments in favor of switching to more expensive artemisinin-based combination treatments (ACTs), the validity of these arguments in the face of financial constraints has not been previously analyzed. In this paper, we use a Bioeconomic model of malaria transmission and evolution of drug resistance to examine questions of optimal treatment strategy and coverage when drug resistance places an additional constraint on choices available to the...
Tipo: Working or Discussion Paper
Palavras-chave: Malaria; Mathematical models; Drug resistance; Bioeconomics; Health Economics and Policy; I10; I19; C61.
Ano: 2003
URL: http://purl.umn.edu/10699

Impact of irrigation on poverty and environment in Ethiopia. Draft Proceeding of the Symposium and Exhibition held at Ghion Hotel, Addis Ababa, Ethiopia 27th -29th November, 2007
Provedor de dados: 31
Autores: Awulachew,   Seleshi Bekele; Loulseged,   Makonnen; Yilma,   Aster Denekew.
Tipo: Presentation
Palavras-chave: Poverty; Crop management; Irrigated farming; Rainfed farming; Irrigation systems; Food security; Water harvesting; Institutions; Environmental effects; Public health; Malaria; GIS; Remote sensing; Crop Production/Industries; Environmental Economics and Policy; Farm Management; Food Consumption/Nutrition/Food Safety; Food Security and Poverty; Health Economics and Policy; Institutional and Behavioral Economics; Resource /Energy Economics and Policy.
Ano: 2008
URL: http://purl.umn.edu/118410

An investigation of the relationship between depth to groundwater and malaria prevalence, Punjab, Pakistan
Provedor de dados: 31
Autores: Donnelly,   M.J.; Birley,   M.H.; Konradsen,   Flemming.
Tipo: Working or Discussion Paper
Palavras-chave: Groundwater; Malaria; Waterborne diseases; Land use; Public health; Farmers; Institutions; Infrastructure; Maps; Statistics; Rice; Farm Management; Health Economics and Policy.
Ano: 1997
URL: http://purl.umn.edu/113607

Does Reducing Malaria Improve Household Living Standards?
Provedor de dados: 31
Autores: Laxminarayan,   Ramanan.
Living in malaria-endemic regions places an economic burden on households even if they do not actually suffer an episode of malaria. Households living with endemic malaria are less likely to have access to economic opportunities and may have to modify agricultural practices and other household behavior to adapt to their disease environment. Data from Vietnam demonstrate that reductions in malaria incidence through government-financed malaria control programs can contribute to higher household income for all households living in endemic areas. Empirically, a 10% decrease in malaria cases at the national level translates to a roughly US $30 million annual economic benefit in the form of improved living standards.
Tipo: Working or Discussion Paper
Palavras-chave: Malaria; Living standards; Disease; Health Economics and Policy; D1; O1; I0.
Ano: 2003
URL: http://purl.umn.edu/10633

Current policy and status of DDT use for malaria control in Ethiopia, Uganda, Kenya and South Africa.
Provedor de dados: 31
Autores: Biscoe,   Melanie L.; Mutero,   Clifford M.; Kramer,   Randall A.
Tipo: Working or Discussion Paper
Palavras-chave: Malaria; Waterborne diseases; Disease vectors; Public health; Policy; Ddt; Legal aspects; Pesticide residues; Case studies; Health Economics and Policy; Research and Development/Tech Change/Emerging Technologies; Research Methods/ Statistical Methods; Teaching/Communication/Extension/Profession.
Ano: 2005
URL: http://purl.umn.edu/92015

The Fight Against Geography: Malaria and Economic Development in Italian Regions
Provedor de dados: 31
Autores: Percoco,   Marco.
Geography has long been considered as a fundamental prerequisite for economic development and growth. In recent years, a growing number of papers have considered the role of physical geography as a determinant of regional growth and development by considering it as a source of “intrinsic advantage”. Malaria is considered to be strictly related to poverty and its geographically-related origin is now widely recognized, i.e. it is endemic only in certain areas of the globe whose environmental and climatic characteristics are ideal for the proliferation of mosquitoes which are the vector for the transmission of the disease. The World Health Organization is currently setting a series of policies aiming to eradicate the disease from Africa, with the specific...
Tipo: Working or Discussion Paper
Palavras-chave: Geography; Regional Growth; Malaria; Political Economy; J100; N300; O100; R100.
Ano: 2011
URL: http://purl.umn.edu/99684

Learning, Misallocation, and Technology Adoption: Evidence from New Malaria Therapy in Tanzania
Provedor de dados: 31
Autores: Adhvaryu,   Achyuta.
I show that malaria misdiagnosis, common in resource-poor settings, decreases the expected effectiveness of an important new therapy–since only a fraction of treated individuals have malaria–and reduces the rate of learning via increased noise. Using pilot program data from Tanzania, I exploit variation in the location and timing of survey enumeration to construct reference groups composed of randomly chosen, geographically and temporally proximate acutely ill individuals. I show that learning is stronger and adoption rates are higher in villages with more misdiagnosis. Subsidizing diagnostic tools or improving initial targeting of new technologies may thus accelerate uptake through learning.
Tipo: Working or Discussion Paper
Palavras-chave: Technology adoption; Learning; Malaria; Tanzania; Health Economics and Policy; International Development; Research and Development/Tech Change/Emerging Technologies; I15; O12; O33.
Ano: 2011
URL: http://purl.umn.edu/115712

Health impacts of small reservoirs in Burkina Faso.
Provedor de dados: 31
Autores: Boelee,   Eline; Cecchi,   Philippe; Kone,   Andre.
In Burkina Faso, at least 1,700 small reservoirs have been constructed, most of them during the last 30 years. Numerous and scattered, these beneficial multipurpose systems combine productive with domestic water uses. However, their environmental and health impacts remain insufficiently documented. This report combines data from different sources into syntheses and national maps, with a focus on water-related diseases. The mitigation of negative impacts requires an integrated approach to specifically identify the enhancing and limiting factors that influence environmental impacts and the transmission of diseases around reservoirs. Public awareness campaigns need to accompany the promotion of preventive and curative measures and the development of...
Tipo: Working or Discussion Paper
Palavras-chave: Reservoirs; Health hazards; River basins; Water resources development; Environmental effects; Waterborne diseases; Malaria; Schistosomiasis; Control methods; Water policy; Environmental Economics and Policy; Health Economics and Policy; Land Economics/Use; Resource /Energy Economics and Policy.
Ano: 2009
URL: http://purl.umn.edu/91869

Mosquito community composition in dynamic landscapes from the Atlantic Forest biome (Diptera, Culicidae)
Provedor de dados: 92
Autores: Guedes,Mário Luís Pessôa; Navarro-Silva,Mário Antônio.
Mosquito community composition in dynamic landscapes from the Atlantic Forest biome (Diptera, Culicidae). Considering that some species of Culicidae are vectors of pathogens, both the knowledge of the diversity of the mosquito fauna and how some environment factors influence in it, are important subjects. In order to address the composition of Culicidae species in a forest reserve in southern Atlantic Forest, we compared biotic and abiotic environmental determinants and how they were associated with the occurrence of species between sunset and sunrise. The level of conservation of the area was also considered. The investigation was carried out at Reserva Natural do Morro da Mina, in Antonina, state of Paraná, Brazil. We performed sixteen mosquito...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diversity; Insecta; Malaria; Shannon trap; Tropical rain forest.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0085-56262014000100014

Plants of the Annonaceae traditionally used as antimalarials: a review
Provedor de dados: 94
Autores: Frausin,Gina; Lima,Renata Braga Souza; Hidalgo,Ari de Freitas; Maas,Paul; Pohlit,Adrian Martin.
Species of the Annonaceae family are used all over the tropics in traditional medicine in tropical regions for the treatment of malaria and other illnesses. Phytochemical studies of this family have revealed chemical components which could offer new alternatives for the treatment and control of malaria. Searches in scientific reference sites (SciFinder Scholar, Scielo, PubMed, ScienceDirect and ISI Web of Science) and a bibliographic literature search for species of Annonaceae used traditionally to treat malaria and fever were carried out. This family contains 2,100 species in 123 genera. We encountered 113 articles reporting medicinal use of one or more species of this family including 63 species in 27 genera with uses as antimalarials and febrifuges....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium falciparum; Plasmodium yoelii nigeriensis.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-29452014000500038

Parasite loads and altitudinal distribution of Liolaemus lizards in the central Chilean Andes
Provedor de dados: 97
Autores: CAROTHERS,JOHN H.; JAKSIC,FABIÁN M.
This study compared the distributions of ten species of Liolaemus lizards in the central Chilean Andes to the distributions of four types of parasites: malaria-causing Plasmodium, gut nematodes, ticks, and mites. We wanted to see if parasite numbers might be a factor in determining distributional limits of the lizards. We found that there was no evidence of malarial infestation of the lizards, that ticks were almost absent, that more often than not mite numbers decreased at the distributional limits of the lizards, and that gut nematodes confined to the herbivorous lizards in our sample may well be beneficial rather than detrimental. Rather than parasitism, other biotic interactions (e.g., predation or competition) are more likely candidates as factors...
Tipo: Journal article
Palavras-chave: Malaria; Plasmodium; Gut nematodes; Ticks; Mites; Chile; Altitudinal gradient.
Ano: 2001
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2001000300013

Ethnobotanical study of antimalarial plants in the middle region of the Negro River, Amazonas, Brazil
Provedor de dados: 36
Autores: TOMCHINSKY,Bernardo; MING,Lin Chau; KINUPP,Valdely Ferreira; HIDALGO,Ari de Freitas; CHAVES,Francisco Célio Maia.
ABSTRACT The middle Rio Negro region is an interesting place to seek novel antimalarial compounds because of the traditional knowledge of the Amazon population in conjunction with the high biodiversity of the region. The objective of this work was to study the use of antimalarial plants in Barcelos, state of Amazonas, Brazil. Fifty-two local specialists from eight different communities were interviewed over one year. The identified plants were collected with the assistance of local specialists, classified to species level and deposited in herbarium. In total, 55 antimalarial plants were identified in use in the region, of which 16 had not been previously reported in other published studies. Many factors could be involved with the use of antimalarial plants...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Ethnobotany; Amazonia; Medicinal plants; Traditional knowledge.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672017000300203

In vitro and in vivo antimalarial activity of the volatile oil of Cyperus articulatus (Cyperaceae)
Provedor de dados: 36
Autores: SILVA,Nazaré Carneiro da; GONÇALVES,Suellen Ferreira; ARAÚJO,Luciana Silva de; KASPER,Aline Aparecida München; FONSECA,Amanda Luisa da; SARTORATTO,Adilson; CASTRO,Kelly Christina Ferreira; MORAES,Tânia Mara Pires; BARATTO,Leopoldo Clemente; VAROTTI,Fernando de Pilla; BARATA,Lauro Euclides Soares; MORAES,Waldiney Pires.
ABSTRACT Malaria is a disease of global tropical distribution, being endemic in more than 90 countries and responsible for about 212 million cases worldwide in 2016. To date, the strategies used to eradicate this disease have been ineffective, without specific preventive measures such as vaccines. Currently, the existing therapeutic arsenal is limited and has become ineffective against the expansion of artemisinin-resistant Plasmodium, demonstrating the need for studies that would allow the development of new compounds against this disease. In this context, we studied the volatile oil obtained from rhizomes of Cyperus articulatus (VOCA), a plant species commonly found in the Amazon region and popularly used as a therapeutic alternative for the treatment of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antiplasmodial; Artemisinin resistance; Chloroquine resistance; Malaria; Plasmodium falciparum; Plasmodium berghei.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672019000400334

A survey of the Anopheles Mosquitoes (Diptera: Culicidae) along the Acre And Purus Rivers, Amazon Basin, Brazil
Provedor de dados: 36
Autores: ZIMMERMAN,Robert H; PAULINO,Francisco Xavier; ARRUDA,Mercia de.
From January 19 to February 25, 1997 an entomological survey of the seringais and larger towns along the Acre and Purus rivers was made as part of the project “Revisitando a Amazônia de Carlos Chagas; da Borracha a Biodiversidad”. Eleven anopheline species and 1285 specimens were collected landing on human baits. The four most abundant species were Anopheles albitarsis s.l. (n=778), A. darlingi (n=359), A. rangeli (n=69) and A. oswaldoi (n=60). A total of 252 larvae were collected of which 10 anopheline species were identified. The most abundant species collected were A. albitarsis s.l. (n=88), A. deaneorum (n=45) and A. triannulatus (n=40). The low numbers of Anopheles collected and the absence of the principal malaria vector A. darlingi at the seringais...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anopheles; Malaria; Amazon.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59671999000100165

Estudo de anofelinos antropofílicos peridomiciliares da Praia da Saudade na Ilha de Cotijuba: uma área endêmica de malária em Belém, Pará
Provedor de dados: 36
Autores: Mascarenhas,Bento Melo; Guimarães,Delma Gomes; Brígida,Manuel Santa; Pinto,Claudeth Souza; Gomes Neto,Henrique Andrade; Pereira,Júlia Daniele Braga.
Apesar da sua localização perto de Belém, Pará, a Ilha de Cotijuba tem sido assolada por surtos de malária durante os últimos anos, principalmente nos meses de abril a maio. A ilha faz parte de um arquipélago situado às margens da baía do Marajó, a 29 km de Belém, constituindo uma parte insular dessa cidade. Cotijuba possui uma área de cerca de 60 km² e uma costa com 20 km de praias, que corresponde a 66% da área total da ilha. Por causa das repetidas epidemias de malária, nosso interesse voltou-se para conhecer as espécies de anofelinos vetoras. Nos anos de 2002 a 2004 foram realizadas coletas periódicas de mosquitos adultos utilizando-se o método de captura manual com atrativo humano no peridomicílio. Foram realizadas seis coletas bimensais com duração...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Anopheles aquasalis; Anopheles intermedius.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0044-59672009000200026

EXPORT AND TRAFFICKING OF Plasmodium PROTEINS WITHIN THE HOST ERYTHROCYTE
Provedor de dados: 37
Autores: WISER,MARK F.
The export and trafficking of parasite proteins within the infected erythrocyte is a complex process and not well understood. Export of proteins from the parasite was previously speculated to involve a specialized compartment originally designated as the secondary endoplasmic reticulum of the Apicomplexa, or sERA. The properties of this Plasmodium export compartment are reviewed in regards to more recent observations about the trafficking of Plasmodium proteins within the host erythrocyte. In addition, a calcium ATPase unique to the Apicomplexa and with homology to the sarcoplasmicendoplasmic reticulum calcium ATPase is discussed in the context of this unique export compartment. It is also speculated that the Plasmodium export element, PEXEL, may play a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Secretory pathway; SERCA; Protein trafficking; Malaria.
Ano: 2007
URL: http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-548X2007000200001

Signal transduction in Plasmodium-Red Blood Cells interactions and in cytoadherence
Provedor de dados: 42
Autores: Cruz,Laura N.; Wu,Yang; Craig,Alister G.; Garcia,Célia R.S.
Malaria is responsible for more than 1.5 million deaths each year, especially among children (Snow et al. 2005). Despite of the severity of malaria situation and great effort to the development of new drug targets (Yuan et al. 2011) there is still a relative low investment toward antimalarial drugs. Briefly there are targets classes of antimalarial drugs currently being tested including: kinases, proteases, ion channel of GPCR, nuclear receptor, among others (Gamo et al. 2010). Here we review malaria signal transduction pathways in Red Blood Cells (RBC) as well as infected RBCs and endothelial cells interactions, namely cytoadherence. The last process is thought to play an important role in the pathogenesis of severe malaria. The molecules displayed on the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cytoadherence; Erythrocyte; Malaria; Plasmodium; Signal transduction.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652012000200024

Current Antimalarial Therapies and Advances in the Development of Semi-Synthetic Artemisinin Derivatives
Provedor de dados: 42
Autores: PINHEIRO,LUIZ C.S.; FEITOSA,LÍVIA M.; SILVEIRA,FLÁVIA F. DA; BOECHAT,NUBIA.
ABSTRACT According to the World Health Organization, malaria remains one of the biggest public health problems in the world. The development of resistance is a current concern, mainly because the number of safe drugs for this disease is limited. Artemisinin-based combination therapy is recommended by the World Health Organization to prevent or delay the onset of resistance. Thus, the need to obtain new drugs makes artemisinin the most widely used scaffold to obtain synthetic compounds. This review describes the drugs based on artemisinin and its derivatives, including hybrid derivatives and dimers, trimers and tetramers that contain an endoperoxide bridge. This class of compounds is of extreme importance for the discovery of new drugs to treat malaria.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium falciparum; Artemisinin; Hybrid.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301251

Spotlight on Plasmodium falciparum evolutionary system in the southeastern Atlantic forest
Provedor de dados: 49
Autores: Laporta,Gabriel Zorello.
Abstract Malaria elimination is now set to occur in Brazil until 2030. While this achievement is feasible, as it is for other endemic regions worldwide, it is important to recognize resistance of parasites and vectors against anti-malarial interventions. Resistance against drugs and insecticides can lead to discontinuities of malaria transmission, known as residual malaria transmission. Herein, we described a novel phenomenon that is occurring in a residual malaria transmission scenario in the southeastern Atlantic forest. This novel phenomenon does not belong to what is known and therefore we decided to explain it based on an evolutionary perspective. Although it shall not be viewed as a threat to public health, the phenomenon has important aspects that...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Anopheles; Biological Evolution; Malaria; Plasmodium falciparum; Rainforest.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1676-06032017000300401

Ontogenetic patterns and genetic variation in Anopheles (Anopheles) intermedius Chagas, 1908 and Anopheles (Anopheles) mattogrossensis Lutz &amp;amp; Neiva, 1911 (Diptera: Culicidae) in the Brazilian Amazon
Provedor de dados: 57
Autores: RODRIGUEZ,G. A. D.; SANTOS,J. M. M. dos; MAIA,J. de F.
Changes in the expression of genes were observed during development in populations of Anopheles (Anopheles) intermedius and Anopheles (Anopheles) mattogrossensis. Esterase showed seven zones of activity: EST1 was present in all developmental stages of both species; EST2 was observed only in larvae of A. intermedius and larvae and pupae of A. mattogrossensis, with greater activity in pupae; EST3 and EST5 were present in all developmental stages, with greater intensity in larvae; EST4 and EST6 showed weak activity in larvae of A. mattogrossensis and was not found in A. intermedius. Leucine aminopeptidase showed four zones of activity, of which LAP1 and LAP2 were found in all stages of A. intermedius, with highest activity in larvae, and in larvae only of A....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anopheles intermedius; Anopheles mattogrossensis; Ontogeny; Isozymes; Malaria.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-71082000000200020

Plasmodium vivax malaria presenting with severe thrombocytopenia
Provedor de dados: 55
Autores: Makkar,Ravinder Pal Singh; Monga,Surabhi Mukhopadhyay Amitabh; Gupta,Ajay Kr.
Plasmodium falciparum and Plasmodium vivax malaria are endemic infections in India and are commonly associated with mild hematological abnormalities. Severe thrombocytopenia is common in isolated falciparum and mixed falciparum/vivax malaria, but is very rare in isolated P.vivax infection. We hereby report a case of severe thrombocytopenia (platelet count of 8x10(9)/L) in a case of vivax malaria. This is only the second case ever reported in the literature of such profound thrombocytopenia in a case of isolated P.vivax malaria.
Tipo: Info:eu-repo/semantics/report
Palavras-chave: Plasmodium vivax; Malaria; Severe thrombocytopenia.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702002000500008

Role of the Parasight-F test in the diagnosis of complicated Plasmodium falciparum malarial infection
Provedor de dados: 55
Autores: Arora,Sandeep; Gaiha,Manorama; Arora,Anju.
An evaluation was made of the diagnostic efficacy and utility of the Parasight-F test in diagnosing Plasmodium falciparum malaria, compared with conventional microscopy, particularly in severe and complicated cases. This study was designed as a prospective, case control hospital-based study. Febrile patients suspected to be suffering from malaria were selected randomly and were subjected to peripheral smear examinations (thick and thin) and Parasight-F tests till the required number of at least 30 cases of P. falciparum infection were identified, including at least 15 complicated cases. In addition 20 cases of P. vivax malarial infection as well as 20 healthy age and sex-matched individuals were taken as two control groups. The outcome measure was the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Diagnosis; Plasmodium falciparum; Parasight-F test.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702003000500008

Clinical aspects of hemolysis in patients with P. vivax malaria treated with primaquine, in the Brazilian Amazon
Provedor de dados: 55
Autores: Ramos Júnior,Wilson M; Sardinha,José FJ; Costa,Mônica RF; Santana,Marli S; Alecrim,Maria GC; Lacerda,Marcus VG.
This report describes the development of hemolysis in eighteen glucose-6-phosphate dehydrogenase deficient patients treated for Plasmodium vivax malaria with chloroquine and primaquine. The most frequent findings accompanying hemolysis were fever and leukocytosis, in addition to anemia requiring red blood cell transfusion, and development of acute renal failure. Hemolysis in patients using primaquine is not infrequent and contributes to the morbidity of infection caused by Plasmodium vivax.
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Malaria; Plasmodium vivax; Treatment; Primaquine; Hemolysis.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000400017

Acute respiratory distress syndrome due to vivax malaria: case report and literature review
Provedor de dados: 55
Autores: Lomar,André V.; Vidal,José E.; Lomar,Frederico P.; Barbas,Carmen Valente; Matos,Gustavo Janot de; Boulos,Marcos.
Severe pulmonary involvement in malaria has been frequently reported in cases of Plasmodium falciparum infection, but rarely in vivax malaria. Among the 11 previous cases of vivax-related severe respiratory involvement described in the literature, all except one developed it after the beginning of anti-malarial treatment; these appear to correspond to an exacerbation of the inflammatory response. We report the case of a 43-year-old Brazilian woman living in a malaria-endemic area, who presented acute respiratory distress syndrome (ARDS) caused by P. vivax before starting anti-malarial treatment. The diagnosis was made based on microscopic methods. A negative rapid immunochromatographic assay, based on the detection of Histidine Rich Protein-2 (HRP-2) of P....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium vivax; Acute respiratory distress syndrome; Acute respiratory failure; Brazil.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702005000500011

An in vivo test to assess mefloquine 25 mg/kg for the treatment of uncomplicated falciparum malaria in Rondônia, Brazil
Provedor de dados: 55
Autores: Basano,S.A.; Bianco,A.; Taylor,W.R..J; Olliaro,P.; Camargo,L.M.A.
Drug-resistant Plasmodium falciparum is undermining malaria control efforts worldwide. In Brazil, mefloquine (MQ) at a dose of 15 mg/kg body weight is used to treat P. falciparum. At this dose, MQ resistance developed rapidly in Thailand. Use of a higher MQ dose may retard the development of resistance. We treated 50 patients aged one to 67 years who had acute, uncomplicated P falciparum malaria using MQ 25 mg/kg. There were no serious adverse events. Two patients complained of dizziness and insomnia. Assessing evaluable patients, the day 42 cure rate was 40/42 [95.2% (95% confidence interval 83.8 to 99.4%)]. Mefloquine was efficacious and well tolerated in this small cohort from the state of Rôndonia.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Mefloquine; Amazon; Rondônia; Therapeutics.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400013

TLR2 and TLR4 mediated host immune responses in major infectious diseases: a review
Provedor de dados: 55
Autores: Mukherjee,Suprabhat; Karmakar,Subhajit; Babu,Santi Prasad Sinha.
Abstract During the course of evolution, multicellular organisms have been orchestrated with an efficient and versatile immune system to counteract diverse group of pathogenic organisms. Pathogen recognition is considered as the most critical step behind eliciting adequate immune response during an infection. Hitherto Toll-like receptors (TLRs), especially the surface ones viz. TLR2 and TLR4 have gained immense importance due to their extreme ability of identifying distinct molecular patterns from invading pathogens. These pattern recognition receptors (PRRs) not only act as innate sensor but also shape and bridge innate and adaptive immune responses. In addition, they also play a pivotal role in regulating the balance between Th1 and Th2 type of response...
Palavras-chave: Toll like receptor (TLR); Trypanosomiasis; Malaria; Filariasis.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000200193

Patient age does not affect mefloquine concentrations in erythrocytes and plasma during the acute phase of falciparum malaria
Provedor de dados: 55
Autores: Vieira,José Luiz Fernandes; Borges,Larissa Maria Guimarães; Ferreira,Michelle Valéria Dias; Rivera,Juan Gonzalo Bardarez; Gomes,Margarete do Socorro Mendonça.
Abstract  Objective To evaluate whether patient age has a significant impact on mefloquine concentrations in the plasma and erythrocytes over the course of treatment for uncomplicated falciparum malaria.  Methods A total of 20 children aged between 8 and 11 years and 20 adult males aged between 22 and 41 years with uncomplicated falciparum malaria were enrolled in the study. Mefloquine was administered to patients in both age groups at a dose of 20 mg kg−1. The steady-state drug concentrations were measured by reversed-phase high performance liquid chromatography.  Results All patients had an undetectable mefloquine concentration on day 0. In adults, the plasma mefloquine concentrations ranged from 770 to 2930 ng mL−1 and the erythrocyte concentrations...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Infectious disease; Parasitology; Mefloquine.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702016000500482

Role of MyD88-adaptor-like gene polymorphism rs8177374 in modulation of malaria severity in the Pakistani population
Provedor de dados: 55
Autores: Rani,Asima; Nawaz,Syed Kashif; Irfan,Shazia; Arshad,Muhammad; Bashir,Razia; Shaheen,Najma.
Abstract  Introduction: The present study was designed to investigate the association between rs8177374 polymorphism and malaria symptoms due to exposure of Plasmodium vivax and Plasmodium falciparum.  Materials and methods: A total of 454 samples were included in the study (228 malaria patients and 226 healthy individuals). Malaria patients, divided into P. vivax and P. falciparum groups on the basis of the causative species of Plasmodium, were categorized into mild and severe on the basis of clinical outcomes according to WHO criteria. Healthy individuals were used as controls. Allele specific PCR based strategy was used for the identification of rs8177374 SNP.  Results: MyD88-adaptor-like gene polymorphism was associated with susceptibility to malaria...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium; Rs8177374; MAL; Pakistani population.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000400418

Evaluation of the rapid diagnostic test OptiMAL for diagnosis of malaria due to Plasmodium vivax
Provedor de dados: 55
Autores: Tarazona,Alonso Soto; Zerpa,Lely Solari; Mendoza Requena,Daniel; Llanos-Cuentas,Alejandro; Magill,Allan.
OBJECTIVE: To determine the sensitivity and specificity of the rapid diagnostic test OptiMAL® for diagnosis of Plasmodium vivax malaria. MATERIAL AND METHODS: We included all the patients who sought medical attention in the San Martin Pangoa Hospital, Junin, an area endemic for vivax malaria in Peru, between October and December 1998, who had fever during the previous 72 hours and who were older than 12 months. The gold standard for diagnosis was thick blood film microscopy. We determined the parasitemia rate for each of the positive slides. We calculated sensitivity, specificity, positive predictive value and negative predictive value of the test. RESULTS: We included 72 patients; 39 of them were positive for P. vivax by microscopic examination. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: OptiMAL; Malaria; Plasmodium vivax; Diagnosis; Dipstick.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000200005

Genetic characterization and evolutionary inference of TNF-α through computational analysis
Provedor de dados: 55
Autores: Awasthi,Gauri; Singh,Suchita; Dash,A.P.; Das,Aparup.
TNF-α is an important human cytokine that imparts dualism in malaria pathogenicity. At high dosages, TNF-α is believed to provoke pathogenicity in cerebral malaria; while at lower dosages TNF-α is protective against severe human malaria. In order to understand the human TNF-α gene and to ascertain evolutionary aspects of its dualistic nature for malaria pathogenicity, we characterized this gene in detail in six different mammalian taxa. The avian taxon, Gallus gallus was included in our study, as TNF-α is not present in birds; therefore, a tandemly placed duplicate of TNF-α (LT-α or TNF-β) was included. A comparative study was made of nucleotide length variations, intron and exon sizes and number variations, differential compositions of coding to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; TNF-α; TNF-β; Evolution; Computational analyses.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702008000500006

Serum ascorbic acid concentration in patients with acute Falciparum malaria infection: possible significance
Provedor de dados: 55
Autores: Hassan,Garba Ibrahim; Gregory,Ubom; Maryam,Haruna.
Falciparum malaria infection is associated with significant destruction of erythrocytes. This leads to the release of toxic metabolic products, including oxidant compounds.We measured the serum concentration of the antioxidant, ascorbic acid, in 129 patients presenting with acute falciparum malaria infection and in 65 healthy individuals. None of the study subjects administered any form of ascorbic acid supplementation within one week prior to participation in this study. The mean serum ascorbate concentration in infected adult males (n = 49, age range 18-50 years) was found to be 2.02 ± 0.20 mg/dL, and it was 2.03 ± 0.24 mg/dL in infected adult females (n = 56, age range 18-50 years). These values were significantly greater than the serum ascorbate levels...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Ascorbate; Antioxidant.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702004000500007

Immune effector mechanisms of the nitric oxide pathway in malaria: cytotoxicity versus cytoprotection
Provedor de dados: 55
Autores: Nahrevanian,Hossein.
Nitric oxide (NO) is thought to be an important mediator and critical signaling molecule for malaria immunopathology; it is also a target for therapy and for vaccine. Inducible nitric oxide synthase (iNOS) is synthesized by a number of cell types under inflammatory conditions. The most relevant known triggers for its expression are endotoxins and cytokines. To date, there have been conflicting reports concerning the clinical significance of NO in malaria. Some researchers have proposed that NO contributes to the development of severe and complicated malaria, while others have argued that NO has a protective role. Infection with parasites resistant to the microbicidal action of NO may result in high levels of NO being generated, which could then damage the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: INOS; Malaria; Nitric oxide; NO; RNI.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702006000400014

Mapping cancer, cardiovascular and malaria research in Brazil
Provedor de dados: 56
Autores: Rodrigues,P.S.; Fonseca,L.; Chaimovich,H.
This paper presents performance indicators for the Brazilian cancer, cardiovascular and malaria research areas from 1981 to 1995. The data show an increasing number of papers since 1981 and author numbers indicate a continuous growth of the scientific community and suggest an expected impact of scientific activity on biomedical education. The data also characterize cardiovascular research as a well-established area and cancer research as a faster growing consolidating field. The 1989-1994 share of Brazilian articles among world publications shows a growing trend for the cancer (1.61) and cardiovascular (1.59) areas, and a decrease for the malaria area (0.89). The burden of the three diseases on society is contrasted by the small number of consolidated...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cancer; Cardiovascular research; Malaria; Bibliometric indicators; Health indicators.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000800001

Characterization of Plasmodium falciparum glutamate dehydrogenase-soluble antigen
Provedor de dados: 56
Autores: Rodríguez-Acosta,A.; Domínguez,N.G.; Aguilar,I.; Girón,M.E.
The major aim of this study was to characterize a soluble Plasmodium falciparum antigen from the plasma of malaria-infected humans and Plasmodium falciparum culture supernatants, using immunoabsorbent techniques and Western blotting. An Mr 60-kDa protein was isolated from the plasma of patients with Plasmodium falciparum malaria by affinity chromatography using rabbit anti-Proteus spp GDH(NADP+) serum as ligand. This protein, present in plasma of patients with acute Plasmodium falciparum infection, in Plasmodium falciparum culture supernatants, and in immune complexes, was tested with Plasmodium falciparum malaria hyperimmune serum from patients living in hyperendemic areas and rabbit anti-Proteus spp GDH(NADP+) serum prepared in the laboratory. In this...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Glutamate-dehydrogenase; Plasmodium falciparum; Exoantigens; Soluble antigens; Malaria; Antigenic enzymes.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000900008

Vitamin B1 and B6 in the malaria parasite: requisite or dispensable?
Provedor de dados: 56
Autores: Wrenger,C.; Knöckel,J.; Walter,R.D.; Müller,I.B.
Vitamins are essential compounds mainly involved in acting as enzyme co-factors or in response to oxidative stress. In the last two years it became apparent that apicomplexan parasites are able to generate B vitamers such as vitamin B1 and B6 de novo. The biosynthesis pathways responsible for vitamin generation are considered as drug targets, since both provide a high degree of selectivity due to their absence in the human host. This report updates the current knowledge about vitamin B1 and B6 biosynthesis in malaria and other apicomplexan parasites. Owing to the urgent need for novel antimalarials, the significance of the biosynthesis and salvage of these vitamins is critically discussed in terms of parasite survival and their exploitation for drug...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Apicomplexa; Pyridoxal phosphate synthase; Vitamin B6; Vitamin B1.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200001

Malaria vaccine: roadblocks and possible solutions
Provedor de dados: 56
Autores: Soares,I.S.; Rodrigues,M.M.
Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium; Vaccine; Immunity; Infectious disease.
Ano: 1998
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000300002

Experimental models in vaccine research: malaria and leishmaniasis
Provedor de dados: 56
Autores: Teixeira,C.; Gomes,R.
Animal models have a long history of being useful tools, not only to test and select vaccines, but also to help understand the elaborate details of the immune response that follows infection. Different models have been extensively used to investigate putative immunological correlates of protection against parasitic diseases that are important to reach a successful vaccine. The greatest challenge has been the improvement and adaptation of these models to reflect the reality of human disease and the screening of vaccine candidates capable of overcoming the challenge of natural transmission. This review will discuss the advantages and challenges of using experimental animal models for vaccine development and how the knowledge achieved can be extrapolated to...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human vaccines; Animal models; Malaria; Leishmaniasis.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200109

Melatonin and N-acetyl-serotonin cross the red blood cell membrane and evoke calcium mobilization in malarial parasites
Provedor de dados: 56
Autores: Hotta,C.T.; Markus,R.P.; Garcia,C.R.S.
The duration of the intraerythrocytic cycle of Plasmodium is a key factor in the pathogenicity of this parasite. The simultaneous attack of the host red blood cells by the parasites depends on the synchronicity of their development. Unraveling the signals at the basis of this synchronicity represents a challenging biological question and may be very important to develop alternative strategies for therapeutic approaches. Recently, we reported that the synchrony of Plasmodium is modulated by melatonin, a host hormone that is synthesized only during the dark phases. Here we report that N-acetyl-serotonin, a melatonin precursor, also releases Ca2+ from isolated P. chabaudi parasites at micro- and nanomolar concentrations and that the release is blocked by 250...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Plasmodium; Calcium; Melatonin; Circadian rhythm; Host-parasite interaction.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001100016

Comparison of the diagnosis of malaria by microscopy, immunochromatography and PCR in endemic areas of Venezuela
Provedor de dados: 56
Autores: Rodulfo,H; De Donato,M; Mora,R; González,L; Contreras,C.E.
Whole blood samples (N = 295) were obtained from different locations in Amazonas and Sucre States, in Venezuela. Malaria was diagnosed by microscopy, OptiMAL™ and polymerase chain reaction (PCR), with Plasmodium vivax, P. falciparum, and P. malariae being detected when possible. We identified 93 infections, 66 of which were caused by P. vivax, 26 by P. falciparum, and 1 was a mixed infection. No infection caused by P. malariae was detected. The sensitivity and specificity of each diagnostic method were high: 95.7 and 97.9% for microscopy, 87.0 and 97.9% for OptiMAL, and 98.0 and 100% for PCR, respectively. Most samples (72.2%) showed more than 5000 parasites/µL blood. The sensitivity of the diagnosis by microscopy and OptiMAL decreased with lower...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Molecular diagnosis of malaria; Microscopic diagnosis of malaria; Polymerase chain reaction; OptiMAL.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000400012

Interruption of the blood-stage cycle of the malaria parasite, Plasmodium chabaudi, by protein tyrosine kinase inhibitors
Provedor de dados: 56
Autores: Gazarini,M.L.; Garcia,C.R.S.
Malaria is a devastating disease caused by a unicellular protozoan, Plasmodium, which affects 3.7 million people every year. Resistance of the parasite to classical treatments such as chloroquine requires the development of new drugs. To gain insight into the mechanisms that control Plasmodium cell cycle, we have examined the effects of kinase inhibitors on the blood-stage cycle of the rodent malaria parasite, Plasmodium chabaudi. In vitro incubation of red blood cells for 17 h at 37ºC with the inhibitors led to a decrease in the percent of infected cells, compared to control treatment, as follows: genistein (200 µM - 75%), staurosporine (1 µM - 58%), R03 (1 µM - 75%), and tyrphostins B44 (100 µM - 66%) and B46 (100 µM - 68%). All these treatments were...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Malaria; Plasmodium chabaudi; Kinase inhibitors; Signal transduction; Genistein; Staurosporin.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001100003

High incidence of co-infection with Malaria and Typhoid in febrile HIV infected and AIDS patients in Ekpoma, Edo State, Nigeria
Provedor de dados: 58
Autores: Agwu,E.; Ihongbe,J.C.; Okogun,G.R.A.; Inyang,N.J.
This survey was designed to determine the prevalence of Plasmodium falciparum and Salmonella Typhi among febrile HIV/AIDS patients in Ekpoma. Malaria and typhoid risk factors in Ekpoma included occupation, poor health facilities and poor sanitation. Malaria and typhoid are highly prevalent among Ekpoma HIV/AIDS patients.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Typhoid; HIV/AIDS; Ekpoma.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822009000200022

A qualitative study exploring perspectives towards rational use of medicines in Pakistan's Malaria Control Program (MCP)
Provedor de dados: 60
Autores: Malik,Madeeha; Hassali,Mohamed Azmi; Shafie,Asrul Akmal; Hussain,Azhar.
Malaria is one of the most important global public health problems threatening the health of the population owing to prevailing socio-economic conditions and epidemiological reasons in Pakistan. This qualitative study has focused on the perspectives held towards the rational use of medicine intervention among malaria control program officials. Eight semi-structured interviews with all officials working for the malaria control program in Islamabad were conducted. The interviews, which were audio-taped and transcribed verbatim, were evaluated by thematic content analysis and by all authors. All respondents agreed on successful implementation of the malaria control program in Pakistan for controlling malaria by improving diagnostic and treatment facilities...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Malaria Control Program; Drug/rational use; Intervention; Pakistan.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000200014

Molecular docking, synthesis and in vitro antimalarial evaluation of certain novel curcumin analogues
Provedor de dados: 60
Autores: Dohutia,Chandrajit; Chetia,Dipak; Gogoi,Kabita; Bhattacharyya,Dibya Ranjan; Sarma,Kishore.
ABSTRACT The receptor protein PfATP6 has been identified as the common target of artemisinin and curcumin. The work was initiated to assess the antimalarial activity of six curcumin derivatives based on their binding affinities and correlating the in silico docking outcome with in vitro antimalarial screening results. A ligand library of thirty two Knoevenagel condensates of curcumin were designed and docked against PfATP6 protein and six compounds with the best binding scores were synthesized and screened for their antimalarial activity against the sensitive 3D7 strain of Plasmodium falciparum. ADME/Tox, pharmacokinetic and pharmacodynamic profiles of the designed compounds were analyzed and reported. 4-FB was found to have similar binding energy to the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Curcumin/synthesis; Curcumin/antimalarial activity; Curcumin/Knoevenagel condensates; PfATP6; Malaria; Docking; In vitro; ADME/Tox.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000400603

Water deficit effect on the accumulation of biomass and artemisinin in annual wormwood(Artemisia annua L., Asteraceae)
Provedor de dados: 61
Autores: Marchese,José A.; Ferreira,Jorge F.S.; Rehder,Vera L.G.; Rodrigues,Osmar.
Despite the importance of Artemisia annua L. as the only source of the anti-parasitic drug artemisinin, little is known on the effects of biotic and abiotic stress on artemisinin accumulation. Water deficit is the most limiting factor on plant growth, however it can trigger secondary metabolite accumulation, depending on the plant growth stage and intensity. A. annua cultivated in growth chambers was submitted to five water deficit treatments (watered, 14, 38, 62 e 86 hours without irrigation). Water deficits of 38 and 62 hours (Yw = -1.39 and -2.51 MPa, respectively) increased leaf artemisinin content, but only 38 hours led to a significant increase in both leaf and plant artemisinin (29%), with no detriment to plant biomass production. The other...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Malaria; Secondary metabolism; Terpene; Drought; Water stress.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-04202010000100001