Consulta: subjectFacets:"Mechanism of toxicity"
Registros recuperados: 1
Data/hora: 11/06/2024 03:51:50

Azaspiracids Increase Mitochondrial Dehydrogenases Activity in Hepatocytes: Involvement of Potassium and Chloride Ions
Provedor de dados: 5
Autores: Pelin, Marco; Kilcoyne, Jane; Florio, Chiara; Hess, Philipp; Tubaro, Aurelia; Sosa, Silvio.
Background: Azaspiracids (AZAs) are marine toxins that are produced by Azadinium and Amphidoma dinoflagellates that can contaminate edible shellfish inducing a foodborne poisoning in humans, which is characterized by gastrointestinal symptoms. Among these, AZA1, -2, and -3 are regulated in the European Union, being the most important in terms of occurrence and toxicity. In vivo studies in mice showed that, in addition to gastrointestinal effects, AZA1 induces liver alterations that are visible as a swollen organ, with the presence of hepatocellular fat droplets and vacuoles. Hence, an in vitro study was carried out to investigate the effects of AZA1, -2, and -3 on liver cells, using human non-tumor IHH hepatocytes. Results: The exposure of IHH cells to...
Tipo: Text
Palavras-chave: Azaspiracids; Hepatocytes; Mitochondrial activity; Mechanism of toxicity.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00494/60526/63989.pdf