Consulta: subjectFacets:"Method validation"
Registros recuperados: 5
Data/hora: 12/06/2024 15:23:19

Otimização e validação de técnica voltamétrica para a detecção e quantificação de compostos fenólicos de interesse agrícola: ácidos fenólicos, flavonoides, taninos e estilbenos.
Provedor de dados: 14
Autores: MAGARELLI, G.; CAVALCANTE, R. S.; CASTRO, C. S. P. de.
bitstream/item/217643/1/Boletim-fenolicos-366-final1.pdf
Tipo: Boletim de Pesquisa e Desenvolvimento (INFOTECA-E)
Palavras-chave: Voltammetry; Method validation; Reducing power; Oxidation potential; Voltametria; Validação de métodos; Poder redutor; Potencial de oxidação; Phenolic acids; Flavonoids; Tannins; Stilbenes.
Ano: 2020
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1126457

Método analítico multirresíduo para determinação de agrotóxicos e seus produtos de degradação em águas superficiais.
Provedor de dados: 14
Autores: SCORZA JUNIOR, R. P.; PAZ, R. B. da S.
bitstream/item/217875/1/BP-86-2020.pdf
Tipo: Boletim de Pesquisa e Desenvolvimento (INFOTECA-E)
Palavras-chave: Validação de método; Monitoramento; Method validation; Resíduo Agrícola; Agrotóxico; Cromatografia; Espectrometria; Pesticide residues; Liquid chromatography; Mass spectrometry; Monitoring.
Ano: 2020
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1126682

Method validation for determination of metals in Vitis labrusca L. grapevine leaf extracts by inductively coupled plasma mass spectrometry (ICP-MS)
Provedor de dados: 42
Autores: BOKOWSKI,LIANE V.V.; SOBRINHO,ROBERTO B.; ARMIJO,CRISTIÁN J.V.; DANI,CAROLINE; HENRIQUES,JOÃO A.P.; FUNCHAL,CLÁUDIA.
ABSTRACT Vitis labrusca L. is the main species used for wine and juice production in Brazil. The grapevine leaves can be used both as functional foods and as cheapest sources for the extraction of phenolic compounds. Besides the antioxidant activity, grapevine leaves exhibited significant anti-inflammatory activity. Therefore, the aim of this study was to develop and validate an analytical methodology to determine the metals selenium (96Se), chromium (53Cr), nickel (62Ni), cadmium (111Cd) and lead (206Pb) in 30 samples of grapevine leaf extracts (Vitis labrusca, Bordo cultivar) using inductively coupled plasma mass spectrometry (ICP-MS). To obtain the grapevine leaf extracts the samples were milled, weighed and digested in microwave oven with nitric acid....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ICP-MS; Metals; Method validation; Vitis labrusca L.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652016000602247

Simultaneous determination of candesartan and hydrochlorothiazide in human plasma by LC-MS/MS
Provedor de dados: 60
Autores: Bonthu,Mohan Gandhi; Atmakuri,Lakshmana Rao; Jangala,Venkateswara Rao.
Abstract A simple, sensitive, rapid and highly efficient LC-MS/MS method was developed for the determination of Candesartan and Hydrochlorothiazide simultaneously in human plasma. The method employed Zorbax eclipse C18 (150 X 4.6 mm, 5µ) column using acetate buffer: acetonitrile (25:75%, v/v) as the mobile phase. The mobile phase flow rate is 1 mL/min which was delivered into the mass spectrometer electron spray ionization chamber. The Liquid/liquid extraction procedure was used in the method for the extraction of analytes. The chromatograph was attached to a negative ion mode tandem mass spectrometer and the method was validated for all the parameters as per the guidelines of US-FDA. The ions were detected in multiple reaction monitoring mode and the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Candesartan; Hydrochlorothiazide; LC-MS/MS; Method validation; Human plasma.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000100625

Residual solvent determination by head space gas chromatography with flame ionization detector in omeprazole API
Provedor de dados: 60
Autores: Pandey,Saurabh; Pandey,Preeti; Kumar,Raj; Singh,Narendra Pal.
Residual solvents in pharmaceutical samples are monitored using gas chromatography with head space. Based on good manufacturing practices, measuring residual solvents is mandatory for the release testing of all active pharmaceutical ingredients (API). The analysis of residual organic solvents (methanol, acetone, cyclohexane, dichloromethane, toluene) in Omeprazole, an active pharmaceutical ingredient was investigated. Omeprazole is a potent reversible inhibitor of the gastric proton pump H+/K+-ATPase. The Head space gas chromatography (HSGC) method described in this investigation utilized a SPB TM-624, Supelco, 30 m long x 0.25 mm internal diameter, 1.4µm-thick column. Since Omeprazole is a thermally labile compound, the selection of the proper injector...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Headspace-gas chromatography; Omeprazole; Method validation; Residual solvents release testing.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502011000200019