Consulta: subjectFacets:"Microemulsion/In vitro release"
Registros recuperados: 1
Data/hora: 01/06/2024 13:38:26

Phenobarbital loaded microemulsion: development, kinetic release and quality control
Provedor de dados: 60
Autores: Figueiredo,Kayo Alves; Neves,Jamilly Kelly Oliveira; Silva,José Alexsandro da; Freitas,Rivelilson Mendes de; Carvalho,André Luis Menezes.
ABSTRACT This study aimed to obtain and characterize a microemulsion (ME) containing phenobarbital (PB). The PB was incorporated in the proportion of 5% and 10% in a microemulsion system containing Labrasol(r), ethanol, isopropyl myristate and purified water. The physicochemical characterization was performed and the primary stability of the ME was evaluated. An analytical method was developed using spectrophotometry in UV  = 242 nm. The kinetics of the in vitro release (Franz model) of the ME and the emulsion (EM) containing PB was evaluated. The incorporation of PB into ME at concentrations of 5 and 10% did not change pH and resistance to centrifugation. There was an increase in particle size, a decrease of conductivity and a change in the refractive...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Microemulsion/physicochemical characterization; Microemulsion/In vitro release; Phenobarbital/microemulsion system/evaluation; Nanotechnology.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502016000200251