Consulta: subjectFacets:"Molecular mechanisms"
Registros recuperados: 3
Data/hora: 07/06/2024 01:31:41

Fish Reproduction Is Disrupted upon Lifelong Exposure to Environmental PAHs Fractions Revealing Different Modes of Action
Provedor de dados: 5
Autores: Vignet, Caroline; Larcher, Thibaut; Davail, Blandine; Joassard, Lucette; Le Menach, Karyn; Guionnet, Tiphaine; Lyphout, Laura; Ledevin, Mireille; Goubeau, Manon; Budzinski, Helene; Begout, Marie-laure; Cousin, Xavier.
Polycyclic aromatic hydrocarbons (PAHs) constitute a large family of organic pollutants emitted in the environment as complex mixtures, the compositions of which depend on origin. Among a wide range of physiological defects, PAHs are suspected to be involved in disruption of reproduction. In an aquatic environment, the trophic route is an important source of chronic exposure to PAHs. Here, we performed trophic exposure of zebrafish to three fractions of different origin, one pyrolytic and two petrogenic. Produced diets contained PAHs at environmental concentrations. Reproductive traits were analyzed at individual, tissue and molecular levels. Reproductive success and cumulative eggs number were disrupted after exposure to all three fractions, albeit to...
Tipo: Text
Palavras-chave: Polycyclic aromatic hydrocarbons; Zebrafish; Spawning success; Fertilization; Gonad differentiation; Molecular mechanisms.
Ano: 2016
URL: https://archimer.ifremer.fr/doc/00355/46641/46465.pdf

Trans-generational Immune Priming in Invertebrates: Current Knowledge and Future Prospects
Provedor de dados: 5
Autores: Tetreau, Guillaume; Dhinaut, Julien; Gourbal, Benjamin; Moret, Yannick.
Trans-generational immune priming (TGIP) refers to the transfer of the parental immunological experience to its progeny. This may result in offspring protection from repeated encounters with pathogens that persist across generations. Although extensively studied in vertebrates for over a century, this phenomenon has only been identified 20 years ago in invertebrates. Since then, invertebrate TGIP has been the focus of an increasing interest, with half of studies published during the last few years. TGIP has now been tested in several invertebrate systems using various experimental approaches and measures to study it at both functional and evolutionary levels. However, drawing an overall picture of TGIP from available studies still appears to be a difficult...
Tipo: Text
Palavras-chave: Trans-generational immune priming; Invertebrate immunity; Host-pathogens interaction; Ecology and evolution; Molecular mechanisms; Scenarios.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00512/62369/66642.pdf

System-Pharmacology Dissection of Traditional Chinese herbs SINI Decoction for Treatment of Cardiovascular Diseases
Provedor de dados: 42
Autores: SHU,ZHIMING; WU,TIANTIAN; SHAHEN,MOHAMED; GUO,ZIHU; SHU,JIA; WANG,HE; SHAR,AKHTAR H.; FARAG,MAYADA R.; ALAGAWANY,MAHMOUD; EL-HACK,MOHAMED E. ABD; LIU,CHAOBIN.
﻿Abstract: Cardiovascular diseases (CVDs) are leading causes of death in the world, owing to noticeable incidence and mortality. Traditional Chinese Medicine (TCM) SINI Decoction (SND) is used to prevent and treat CVDs, which has attracted extensive attention for its moderate and little side effects. However, the involved molecular mechanisms are exceedingly complicated and remain unclear. Systems pharmacology, as a novel approach that integrates systems biology and pharmacology plays a significant role in investigating the molecular mechanism of TCM. In systems pharmacology approach, we use to systematically uncover the mechanisms of action in Chinese medicinal formula SND as an effective treatment for CVDs, which mainly includes:1) molecular database...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Systems pharmacology; SINI Decoction; Cardiovascular Diseases; Molecular mechanisms; Traditional Chinese herbs.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000500804