Consulta: subjectFacets:"Monozygotic twins"
Registros recuperados: 2
Data/hora: 12/06/2024 11:03:12

Expression in normals and in subjects with schizophrenia of a novel gene fragment originally isolated from monozygotic twins discordant for schizophrenia
Provedor de dados: 74
Autores: Zumárraga,Mercedes; Andía,Isabel; Dávila,Ricardo; Miller,Jeannette C.; Friedhoff,Arnold J.
Differentially expressed clones from subtracted cDNA libraries of a pair of monozygotic twins discordant for schizophrenia have been reported in the literature. The clones were expressed in lymphocytes from the healthy twin, but not from the schizophrenic twin. In the current study, we assessed the expression of one of these clones, oksc12b, in 10 normal controls and in 10 patients who met DSM-IV criteria for schizophrenia and had never received neuroleptic medication. We hypothesized that this clone would be differentially expressed in normal controls and in the schizophrenic patients, and that its expression could be a peripheral marker of the disease. Lymphocytes were isolated and total RNA was purified, reverse-transcribed, and quantified by two PCR...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Monozygotic twins; MRNA; Schizophrenia.
Ano: 2004
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572004000100004

Influence of intrauterine and extrauterine growth on neurodevelopmental outcome of monozygotic twins
Provedor de dados: 56
Autores: Reolon,R.K.; Rotta,N.T.; Agranonik,M.; Silva,A.A. Moura da; Goldani,M.Z.
There have been indications that intrauterine and early extrauterine growth can influence childhood mental and motor function. The objective of the present study was to evaluate the influence of intrauterine growth restriction and early extrauterine head growth on the neurodevelopmental outcome of monozygotic twins. Thirty-six monozygous twin pairs were evaluated at the corrected age of 12 to 42 months. Intrauterine growth restriction was quantified using the fetal growth ratio. The effects of birth weight ratio, head circumference at birth and current head circumference on mental and motor outcomes were estimated using mixed-effect linear regression models. Separate estimates of the between (interpair) and within (intrapair) effects of each measure on...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Intrauterine growth restriction; Neurodevelopment; Monozygotic twins; Fetal growth ratio; Head circumference; Neurocognitive development.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000800010