Consulta: subjectFacets:"Neural stem cells"
Registros recuperados: 4
Data/hora: 01/06/2024 09:48:38

Olfactory Epithelium as an Infinitive Source of Neural Stem Cells for Derivation of Inner Ear Hair Cells
Provedor de dados: 77
Autores: Bahmani,Tahere; Gholami,Samira; Mostafaie,Ali; Karimi,Ebrahim; Hoseinkhani,Zohreh; Azad,Taha; Mahdizadeh,Hamid; Mansouri,Kamran.
Surgical techniques for treatment of sensory neural hearing loss (SNHL) have unpredictable outcomes and in recent years cell therapy investigated for treatment of SNHL. Olfactory epithelium proceed neurogenesis during life time and provide an easily accessible source of neural stem cells. So the aim of this study was isolating neural stem cells from olfactory epithelium of rat and differentiation of these cells into hair cells of inner ear in vitro. The epithelium tissue of olfactory mucosa of rats were removed and digested by collagenase H. The digested tissue was cultured in flasks in suspension forms to create spheres. Spheres were passaged and from passage 2 spheres selected for differentiation. At this stage cells of spheres isolated from each other...
Tipo: Journal article
Palavras-chave: Olfactory mucosa; Neural stem cells; Hair cells; Differentiation; Rat.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200004

The lizard cerebral cortex as a model to study neuronal regeneration
Provedor de dados: 42
Autores: LOPEZ-GARCIA,CARLOS; MOLOWNY,ASUNCION; NACHER,JUAN; PONSODA,XAVIER; SANCHO-BIELSA,FRANCISCO; ALONSO-LLOSA,GREGORI.
The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex (affecting up to 95% of its neurons) results in a cascade of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Medial cortex; Hippocampus; Postnatal neurogenesis; Neural stem cells; Zinc; Regeneration.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000100006

A cell junction pathology of neural stem cells leads to abnormal neurogenesis and hydrocephalus
Provedor de dados: 48
Autores: Rodríguez,Esteban M; Guerra,María M; Vío,Karin; González,César; Ortloff,Alexander; Bátiz,Luis F; Rodríguez,Sara; Jara,María C; Muñoz,Rosa I; Ortega,Eduardo; Jaque,Jaime; Guerra,Francisco; Sival,Deborah A; Dunnen,Wilfred F. A. den; Jiménez,Antonio J; Domínguez-Pinos,María D; Pérez-Fígares,José M; McAllister,James P; Johanson,Conrad.
Most cells of the developing mammalian brain derive from the ventricular (VZ) and the subventricular (SVZ) zones. The VZ is formed by the multipotent radial glia/neural stem cells (NSCs) while the SVZ harbors the rapidly proliferative neural precursor cells (NPCs). Evidence from human and animal models indicates that the common history of hydrocephalus and brain maldevelopment starts early in embryonic life with disruption of the VZ and SVZ. We propose that a "cell junction pathology" involving adherent and gap junctions is a final common outcome of a wide range of gene mutations resulting in proteins abnormally expressed by the VZ cells undergoing disruption. Disruption of the VZ during fetal development implies the loss of NSCs whereas VZ disruption...
Tipo: Journal article
Palavras-chave: Hydrocephalus; Abnormal neurogenesis; Neural stem cells; Stem cell transplantation.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000300005

Regulation and function of neurogenesis in the adult vertebrate brain
Provedor de dados: 56
Autores: Mendez-Otero,R.; Zaverucha-do-Valle,C.; Gubert,F.; Freitas,G.R. de; Santiago,M.F.
Most adult tissues retain a reservoir of self-renewing, multipotent stem cells that can generate differentiated tissue components. Until recently, the brain was thought to be an exception to this rule and for many years the pervasive dogma of neurobiology relegated neurogenesis to the embryonic and earlier postnatal stages of development. The discovery of constant neuronal replacement in the adult brain has changed the way we think about neurological diseases and about the exploration of new strategies for brain repair. In this review we will explore the potential of adult neural stem cells and we will present some of our own work on this subject. We will also discuss the possibility that adult neurogenesis and neuronal replacement may also play a role in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neural stem cells; Adult neurogenesis; 9-O-acetyl GD3; Gangliosides.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001000012