Consulta: subjectFacets:"Neurogenesis"
Registros recuperados: 8
Data/hora: 10/06/2024 08:11:29

Expression of D-type cyclins in differentiating cells of the mouse spinal cord
Provedor de dados: 74
Autores: Salles,Patricy de Andrade; Fortes,Juliana Chagas; Guedes,Maria Izabel Florindo; Weller,Mathias.
The D-type cyclins form complexes with the cyclin dependent (CD) kinases CDK4 and CDK6 and promote the G1-S phase transition of the cell cycle by antagonizing the retinoblastoma suppresser protein pRB. In the developing nervous system D-type cyclins show spatially and temporally dynamic patterns of expression. We demonstrated that cyclin D1 was transiently expressed in differentiating spinal cord ventral interneurons while cyclin D3 protein was expressed in differentiating motor neurons and dorsal interneurons. This expression of cyclin D3 in neurons of the mantle zone was extended to all regions of the spinal cord at E15.5. The results suggest that cyclin D1 and D3 have specific functions in differentiating neurons. Similarly, in the developing...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cell cycle; D-type cyclins; Midbrain-hindbrain region; Neurogenesis; Spinal cord.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572007000400032

Enhanced brain expression of genes related to cell proliferation and neural differentiation is associated with cortisol receptor expression in fishes
Provedor de dados: 5
Autores: Sadoul, Bastien; Alfonso, Sebastien; Bessa, E.; Bouchareb, A.; Blondeau-bidet, E.; Clair, P.; Chatain, Beatrice; Begout, Marie-laure; Geffroy, Benjamin.
Stress enhances or inhibits neurogenesis in mammals and some fish species. The link between the two processes is still unclear. Most studies have been performed in very specific stressful or altered environments. Despite the known inter-individual divergence in coping abilities within populations, the relationship between the stress axis and neurogenesis has never been addressed in unstressed individuals. Here we correlate brain expression of the pcna (proliferating cell nuclear antigen) and neurod1 (neurogenic differentiation factor 1) genes, two markers of neurogenesis, with transcripts of cortisol receptors in three fish species living in very distinct environments. Within the three species, individuals with the highest expression of neurogenesis genes...
Tipo: Text
Palavras-chave: Neurogenesis; Stress; Glucocorticoid receptor; Mineralocorticoid receptor; Hypothalamo-pituitary-interrenal axis.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00444/55560/57164.pdf

Nature-Based Tourism Elicits a Phenotypic Shift in the Coping Abilities of Fish
Provedor de dados: 5
Autores: Geffroy, Benjamin; Sadoul, Bastien; Bouchareb, Amine; Prigent, Sylvain; Bourdineaud, Jean-paul; Gonzalez-rey, Maria; Morais, Rosana N.; Mela, Maritana; Carvalho, Lucelia Nobre; Bessa, Eduardo.
Nature-based tourism is gaining extensive popularity, increasing the intensity and frequency of human-wildlife contacts. As a consequence, behavioral and physiological alterations were observed in most exposed animals. However, while the majority of these studies investigated the effects of punctual exposure to tourists, the consequences of constant exposition to humans in the wild remains overlooked. This is an important gap considering the exponential interest for recreational outdoor activities. To infer long-term effects of intensive tourism, we capitalized on Odontostilbe pequira, a short-lived sedentary Tetra fish who spends its life close to humans, on which it feeds on dead skin. Hence, those fish are constantly exposed to tourists throughout their...
Tipo: Text
Palavras-chave: Coping style; Ecotourism; Conservation; Behavior; Gene expression; Cortisol; Neurogenesis; Fish.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00423/53470/54366.pdf

Gamma Radiation-induced Impairment of Hippocampal Neurogenesis,Comparison of Single and Fractionated Dose Regimens
Provedor de dados: 77
Autores: Khoshbin khoshnazar,A. R; Jahanshahi,M; Azami,N. S.
Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male rats entered to study. Radiation absorbed dose to midbrain was 10 Gy, delivered by routine cobalt radiotherapy machine which its output was measured 115.24 cGy/min. The rats were divided in four groups of sixes, including groups of control, single fraction 10 Gy, fractionated 10 Gy and finally anaesthesia sham group. Number of pyramidal nerve cells was counted in two regions of hippocampus formation (CA1 and CA3). The radiation could reduce the number of cells in two regions of hippocampus significantly...
Tipo: Journal article
Palavras-chave: Hippocampus; Neurogenesis; Radiation; Fractionation.
Ano: 2012
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100026

Morphological Characterization of Gecko's (Eublepharis macularius) Glial Cells in Culture
Provedor de dados: 77
Autores: Grzesiak,Jakub; Marycz,Krzysztof; Szarek,Dariusz; Jarmundowicz,Wlodzimierz.
Central nervous system of reptiles has the ability to grow and regenerate during adult life of the animal. Therefore, cells creating CNS of this animal class should compound substances or molecules enabling neuroregeneration. Cells directly involved in this process have not been clearly characterized, especially in cell culture environment. Morphology of reptilian glial adherent cells should be known better to find any differences from mammalian CNS cells. We isolated glial cells from olfactory bulb and cerebrum from gecko (Eublepharis macularius) and cultured separately. We have observed populations of cells with proliferative capacity in both types of cultures. Also, we have detected lipid molecules deposits within their cytoplasm, which localization was...
Tipo: Journal article
Palavras-chave: Glial cells; Neurogenesis; Neuroregeneration; Reptile.
Ano: 2013
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022013000300008

Neurochemical phenotype and birthdating of specific cell populations in the chick retina
Provedor de dados: 42
Autores: calaza,Karin da Costa; Gardino,Patricia F.
The chick embryo is one of the most traditional models in developing neuroscience and its visual system has been one of the most exhaustively studied. The retina has been used as a model for studying the development of the nervous system. Here, we describe the morphological features that characterize each stage of the retina development and studies of the neurogenesis period of some specific neurochemical subpopulations of retinal cells by using a combination of immunohistochemistry and autoradiography of tritiated-thymidine. It could be concluded that the proliferation period of dopaminergic, GABAergic, cholinoceptive and GABAceptive cells does not follow a common rule of the neurogenesis. In addition, some specific neurochemical cell groups can have a...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Developing; Neurogenesis; Neurotransmitter systems; Ontogenesis; Proliferation.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000300007

The origin of cortical neurons
Provedor de dados: 56
Autores: Parnavelas,J.G.
Neurons of the mammalian cerebral cortex comprise two broad classes: pyramidal neurons, which project to distant targets, and the inhibitory nonpyramidal cells, the cortical interneurons. Pyramidal neurons are generated in the germinal ventricular zone, which lines the lateral ventricles, and migrate along the processes of radial glial cells to their positions in the developing cortex in an `inside-out' sequence. The GABA-containing nonpyramidal cells originate for the most part in the ganglionic eminence, the primordium of the basal ganglia in the ventral telencephalon. These cells follow tangential migratory routes to enter the cortex and are in close association with the corticofugal axonal system. Once they enter the cortex, they move towards the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neurogenesis; Migration; Cortical development.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200003

Nuclear exclusion of transcription factors associated with apoptosis in developing nervous tissue
Provedor de dados: 56
Autores: Linden,R.; Chiarini,L.B.
Programmed cell death in the form of apoptosis involves a network of metabolic events and may be triggered by a variety of stimuli in distinct cells. The nervous system contains several neuron and glial cell types, and developmental events are strongly dependent on selective cell interactions. Retinal explants have been used as a model to investigate apoptosis in nervous tissue. This preparation maintains the structural complexity and cell interactions similar to the retina in situ, and contains cells in all stages of development. We review the finding of nuclear exclusion of several transcription factors during apoptosis in retinal cells. The data reviewed in this paper suggest a link between apoptosis and a failure in the nucleo-cytoplasmic partition of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Programmed cell death; Retina; Neurogenesis; Development; Nuclear membrane.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000700003