Consulta: subjectFacets:"Neuron"
Registros recuperados: 9
Data/hora: 11/06/2024 09:29:59

Hippocampal Neuronal Apoptosis in Rat Offspring Due to Gestational Diabetes
Provedor de dados: 77
Autores: Ghafari,Soraya; Asadi,Ebrahim; Shabani,Ronak; Golalipour,Mohammad Jafar.
Gestational diabetes mellitus (GDM) defined as impaired glucose tolerance affects approximately 6 % of all pregnant women who have never before had diabetes, but who do have high blood glucose levels during pregnancy. This study was done to evaluate the apoptosis in the neuronal cells in the CA1, CA2 and CA3 subfields of hippocampus and dentate gyrus in offspring of gestational diabetes at the 7, 21 and 28 d in postnatal rats. Thirty Wistar rat dams were randomly allocated in control and diabetic group. Dams in diabetic group were received 40 mg/kg/BW of streptozotocin at the first day of gestation and control groups received an equivalent volume normal saline injection intraperitoneally (IP). Six offspring of GDM and control dams, at the 7, 21, 28...
Tipo: Journal article
Palavras-chave: Gestational diabetes; Hippocampus; Neuron; Apoptosis; TUNEL Assay; Dentate gyrus; Rat.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000100029

Alterations of the Giant Pyramidal Neurons (Betz Cells) in Brain Cortex of Rat Offspring Born from Gestational Diabetic Dams: A Morphometric Study
Provedor de dados: 77
Autores: Ghafari,Soraya; Golalipour,Elnaz; Golalipour,Mohammad Jafar.
A few studies reported the adverse effects of gestational diabetes on hippocampus and spinal cord of rat offspring. Giant pyramidal neurons are giant pyramidal neurons located in fifth layers of the gray matter in the primary motor cortex. Therefore, this study was conducted to determine the effect of gestational diabetes on the giant pyramidal neurons and the thickness of internal pyramidal layer in the brain cortex of rat offspring. On day 1 of gestation, 10 Wistar rat dams were randomly allocated into two control and diabetic groups. Five animals in diabetic group received 40 mg/kg/BW of Streptozotocin (intraperitoneally) and control animals received normal saline. We randomly selected six offspring of every subject in both groups at day 28, 56 and 84....
Tipo: Journal article
Palavras-chave: Gestational diabetes; Neuron; Giant pyramidal neurons; Cerebral cortex; Rat offspring.
Ano: 2015
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022015000300049

A metallic impregnation technique adapted to study the honeybee Apis mellifera L. brain
Provedor de dados: 82
Autores: Calábria,Luciana K; Teixeira,Renata R; Moraes,Viviane R A; Santos,Ana Alice D; Espindola,Foued S.
In order to visualize the distribution pattern of the neuronal bodies and neurofibrils in the honeybee brain, we adapted a metallic impregnation technique first described for vertebrate nervous system by Ramón y Cajal. The honeybee brain constitution plays a key role in the development of learning and memory capacities. The general characteristics observed in the honeybee brain, stained by metallic impregnation, revealed its anatomical and morphological constitution in agreement with studies of other insect brains using different techniques. Metallic impregnation evidenced the optic lobe neuropils, the ocelli fiber cells, the neuron extensions of the calyces, and the axon bundles that involve the antennal glomeruli, as well as the neuron extensions in the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neurofibril; Neuron; Invertebrate; Silver.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1519-566X2010000500008

Neuron-derived CCL2 contributes to microglia activation and neurological decline in hepatic encephalopathy
Provedor de dados: 48
Autores: Zhang,Li; Tan,Jinyun; Jiang,Xiaoping; Qian,Weiwei; Yang,Ting; Sun,Xijun; Chen,Zhaohui; Zhu,Qiwen.
Abstract  Background  CCL2 was up-regulated in neurons and involved in microglia activation and neurological decline in mice suffering from hepatic encephalopathy (HE). However, no data exist concerning the effect of neuron-derived CCL2 on microglia activation in vitro.  Methods  The rats were pretreated with CCL2 receptor inhibitors (INCB or C021, 1 mg/kg/day i.p.) for 3 days prior to thioacetamide (TAA) administration (300 mg/kg/day i.p.) for inducing HE model. At 8 h following the last injection (and every 4 h after), the grade of encephalopathy was assessed. Blood and whole brains were collected at coma for measuring CCL2 and Iba1 expression. In vitro, primary neurons were stimulated with TNF-&amp;#945;, and then the medium were collected for addition...
Tipo: Journal article
Palavras-chave: Hepatic encephalopathy; Neuron; Microglia; Chemokine CC motif ligand 2.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100218

Location matters: the endoplasmic reticulum and protein trafficking in dendrites
Provedor de dados: 48
Autores: Ramírez,Omar A; Härtel,Steffen; Couve,Andrés.
Neurons are highly polarized, but the trafficking mechanisms that operate in these cells and the topological organization of their secretory organelles are still poorly understood. Particularly incipient is our knowledge of the role of the neuronal endoplasmic reticulum. Here we review the current understanding of the endoplasmic reticulum in neurons, its structure, composition, dendritic distribution and dynamics. We also focus on the trafficking of proteins through the dendritic endoplasmic reticulum, emphasizing the relevance of transport, retention, assembly of multi-subunit protein complexes and export. We additionally discuss the roles of the dendritic endoplasmic reticulum in synaptic plasticity.
Tipo: Journal article
Palavras-chave: Endoplasmic reticulum; Protein trafficking; Dendrites; Neuron.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000100003

Jaime Alvarez and the case against slow axoplasmic transport: some epistemological reflections
Provedor de dados: 48
Autores: SERANI-MERLO,ALEJANDRO.
The 'slow axoplasmic transport theory' has been the prevailing view over the last forty years in order to explain the metabolic maintenance of neuronal axons and nerve endings. A significant amount of evidence against this theoretic interpretation of the existing experimental data has been presented by J. Alvarez, A. Giuditta and E. Koenig in an exhaustive review. They propose an alternative theoretical interpretation called the 'local synthesis model', integrating recent evidence for axon biology and regeneration. We present some epistemological considerations that reinforce the above criticisms and propositions.
Tipo: Journal article
Palavras-chave: Axon biology; Biological epistemology; Neuron; Slow axonal transport.
Ano: 2001
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200015

Cross-talk between neurons and glia: highlights on soluble factors
Provedor de dados: 56
Autores: Gomes,F.C.A.; Spohr,T.C.L.S.; Martinez,R.; Moura Neto,V.
The development of the nervous system is guided by a balanced action between intrinsic factors represented by the genetic program and epigenetic factors characterized by cell-cell interactions which neural cells might perform throughout nervous system morphogenesis. Highly relevant among them are neuron-glia interactions. Several soluble factors secreted by either glial or neuronal cells have been implicated in the mutual influence these cells exert on each other. In this review, we will focus our attention on recent advances in the understanding of the role of glial and neuronal trophic factors in nervous system development. We will argue that the functional architecture of the brain depends on an intimate neuron-glia partnership.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Neuron-glia interaction; Trophic factors; Astrocyte; Neuron; Nervous system.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000500008

The extracellular matrix provides directional cues for neuronal migration during cerebellar development
Provedor de dados: 56
Autores: Porcionatto,M.A.
Normal central nervous system development relies on accurate intrinsic cellular programs as well as on extrinsic informative cues provided by extracellular molecules. Migration of neuronal progenitors from defined proliferative zones to their final location is a key event during embryonic and postnatal development. Extracellular matrix components play important roles in these processes, and interactions between neurons and extracellular matrix are fundamental for the normal development of the central nervous system. Guidance cues are provided by extracellular factors that orient neuronal migration. During cerebellar development, the extracellular matrix molecules laminin and fibronectin give support to neuronal precursor migration, while other molecules...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Extracellular matrix; Central nervous system; Cerebellum; Neuron; Migration.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300001

Transient outward potassium current and Ca2+ homeostasis in the heart: beyond the action potential
Provedor de dados: 56
Autores: Bassani,R.A.
Normal central nervous system development relies on accurate intrinsic cellular programs as well as on extrinsic informative cues provided by extracellular molecules. Migration of neuronal progenitors from defined proliferative zones to their final location is a key event during embryonic and postnatal development. Extracellular matrix components play important roles in these processes, and interactions between neurons and extracellular matrix are fundamental for the normal development of the central nervous system. Guidance cues are provided by extracellular factors that orient neuronal migration. During cerebellar development, the extracellular matrix molecules laminin and fibronectin give support to neuronal precursor migration, while other molecules...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Extracellular matrix; Central nervous system; Cerebellum; Neuron; Migration.
Ano: 2006
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000300010