Consulta: subjectFacets:"Nonlinear dynamical systems"
Registros recuperados: 1
Data/hora: 02/06/2024 08:54:09

Optimal control of bacterial growth for the maximization of metabolite production
Provedor de dados: 5
Autores: Yegorov, Ivan; Mairet, Francis; De Jong, Hidde; Gouze, Jean-luc.
Microorganisms have evolved complex strategies for controlling the distribution of available resources over cellular functions. Biotechnology aims at interfering with these strategies, so as to optimize the production of metabolites and other compounds of interest, by (re)engineering the underlying regulatory networks of the cell. The resulting reallocation of resources can be described by simple so-called self-replicator models and the maximization of the synthesis of a product of interest formulated as a dynamic optimal control problem. Motivated by recent experimental work, we are specifically interested in the maximization of metabolite production in cases where growth can be switched off through an external control signal. We study various optimal...
Tipo: Text
Palavras-chave: Optimal control; Nonlinear dynamical systems; Mathematical modelling; Bacterial growth; Biotechnology.
Ano: 2019
URL: https://archimer.ifremer.fr/doc/00486/59791/63028.pdf