Consulta: subjectFacets:"Open-field"
Registros recuperados: 5
Data/hora: 09/06/2024 03:57:58

EFFECTS OF SCORPION Tityus serrulatus VENOM TOXIN TS-8F ON RAT LEARNING AND MEMORY
Provedor de dados: 79
Autores: MARUO,V. M.; LEBRUN,I.; DORCE,V. A. C.
Scorpion venom neurotoxins are responsible for toxicity and pharmacological effects. They are active in sodium and potassium channels leading to an increase in the release of neurotransmitters, such as glutamate. Glutamate is found in large quantities in the hippocampus (HPC) and is involved in the long-term potentiation (LTP) induction. The HPC is known to be related to certain kinds of memory. The aim of this study is to evaluate the effects of Tityus serrulatus TS-8F toxin on rat behavior with emphasis on learning and memory. We analyzed the effects of different doses of TS-8F on rat behavior in home cages, open-field (habituation), inhibitory avoidance, T-maze, and hippocampus morphology. In the first two experiments, 0.05µg/animal dose of TS-8F did...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Learning and memory; Scorpion neurotoxin; Tityus serrulatus; T-maze; Open-field; Passive avoidance; TS-8F toxin.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-79302002000100007

Antidepressant-like effect of lead in adult mice
Provedor de dados: 56
Autores: Mantovani,M.; Matteussi,A.S.; Rodrigues,A.L.S.
It has been reported that lead can cause behavioral impairment by inhibiting the N-methyl-D-aspartate (NMDA) receptor complex. MK-801, a noncompetitive NMDA receptor antagonist, exhibits an antidepressant-like action in the forced swimming test. The purpose of the present study was to determine whether subacute lead exposure in adult male Swiss mice weighing 30-35 g causes an antidepressant-like action in a forced swimming test. Mice were injected intraperitoneally (ip) with 10 mg/kg lead acetate or saline daily for 7 consecutive days. Twenty-four hours after the last treatment, the saline and lead-treated mice received an injection of MK-801 (0.01 mg/kg, ip) or saline and were tested in forced swimming and in open-field tests. Immobility time was...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Lead acetate; Forced swimming test; Depression; Open-field.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200017

Defense reaction induced by a metabotropic glutamate receptor agonist microinjected into the dorsal periaqueductal gray of rats
Provedor de dados: 56
Autores: Molchanov,M.L.; Guimarães,F.S.
The behavioral effects of trans-(±)-1-amino-1,3-cyclopentanedicarboxylic acid (t-ACPD), a metabotropic glutamate receptor (mGluR) agonist, or 0.9% (w/v) saline, injected into the dorsal periaqueductal gray (DPAG), was investigated. Male Wistar rats showed defense reactions characterized by jumps toward the top edges of the cages (saline = 0 vs t-ACPD = 6.0, medians P&amp;lt;0.05) and gallops (saline = 0 vs t-ACPD = 10.0, medians P&amp;lt;0.05) during the 60-s period after the beginning of the injection. In another experiment animals were placed inside an open arena for 5 min immediately after injection. Their behavior was recorded by a video camera and a computer program analyzed the videotapes. Eleven of fifteen rats injected with t-ACPD showed a...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Periaqueductal gray; Metabotropic glutamate receptors; Defense behavior; T-ACPD; Open-field; Rats.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999001200013

Effects of septal cholinergic lesion on rat exploratory behavior in an open-field
Provedor de dados: 56
Autores: Lamprea,M.R.; Cardenas,F.P.; Silveira,R.; Walsh,T.J.; Morato,S.
The medial septum participates in the modulation of exploratory behavior triggered by novelty. Also, selective lesions of the cholinergic component of the septohippocampal system alter the habituation of rats to an elevated plus-maze without modifying anxiety indices. We investigated the effects of the intraseptal injection of the cholinergic immunotoxin 192 IgG-saporin (SAP) on the behavior of rats in an open-field. Thirty-nine male Wistar rats (weight: 194-230 g) were divided into three groups, non-injected controls and rats injected with either saline (0.5 µl) or SAP (237.5 ng/0.5 µl). Twelve days after surgery, the animals were placed in a square open-field (120 cm) and allowed to freely explore for 5 min. After the test, the rats were killed by...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Exploratory behavior; Open-field; Cholinergic immunotoxin; Medial septum; Saporin.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003000200011

Thigmotactic responses in an open-field
Provedor de dados: 56
Autores: Lamprea,M.R.; Cardenas,F.P.; Setem,J; Morato,S.
The goal of the present study was to investigate the role of thigmotaxis (the tendency to remain close to vertical surfaces) in rat exploratory behavior in an open-field. Thigmotaxis was investigated in a parametric way, using 24 experimentally adult naive male Wistar rats (210-230 g). Exploratory behavior was studied in an open-field (N = 12) in 5-min sessions and behavior was analyzed in terms of where it occurred: in areas surrounded by two, one, or no walls. Another group of rats (N = 12) was studied in an open-field with blocks placed near two of the corners so as to make these corner areas surrounded by three walls. The floor of the open-fields was divided into 20-cm squares in order to locate the exact place of occurrence of each behavior. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Exploratory behavior; Thigmotaxis; Open-field; Rearing behavior; Grooming; Locomotion.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000200010