Consulta: subjectFacets:"Pancreas"
Registros recuperados: 18
Data/hora: 07/06/2024 08:11:50

Use of rotavirus virus-like particles as surrogates to evaluate virus persistence in shellfish
Provedor de dados: 5
Autores: Loisy, Fabienne; Atmar, R; Le Saux, Jean-claude; Cohen, J; Caprais, Marie-paule; Pommepuy, Monique; Le Guyader, Soizick.
Rotavirus virus-like particles (VLPs) and MS2 bacteriophages were bioaccumulated in bivalve mollusks to evaluate viral persistence in shellfish during depuration and relaying under natural conditions. Using this nonpathogenic surrogate virus, we were able to demonstrate that about 1 log(10) of VLPs was depurated after 1 week in warm seawater (22 degrees C). Phage MS2 was depurated more rapidly (about 2 log(10) in 1 week) than were VLPs, as determined using a single-compartment model and linear regression analysis. After being relayed in the estuary under the influence of the tides, VLPs were detected in oysters for up to 82 days following seeding with high levels of VLPs (concentration range between 10(10) and 10(9) particles per g of pancreatic tissue)...
Tipo: Text
Palavras-chave: Seawater; Viral diseases; Bioaccumulation; Depuration; Contamination; Model; Pancreas; Regression analysis; Shellfish; Phages; Virus.
Ano: 2005
URL: http://archimer.ifremer.fr/doc/2005/publication-1233.pdf

Variations in The Vascular Supply of Pancreas and Transverse Colon: A Case Report
Provedor de dados: 77
Autores: Silva Júnior,L. M; Alexandre,M; Gonçalves,L; Silva,F. S; Caetano,A. G.
During anatomical dissection of the abdominal cavity of an adult male corpse, a changing pattern of vascular supply of pancreas and of the transverse colon was observed. The inferior pancreatic artery and the middle colic artery arose from a common trunk of the superior mesenteric artery. Moreover, the lienal artery did not direct a dorsal branch to the neck of the pancreas, but rather sent two greater pancreatic arteries (proximal and distal) to the body of the gland and one caudal artery to the terminal portion of the pancreas. We also observed a large communicating branch between the proximal portion of the middle colic artery and the ascending branch of the left colic artery, previously described as artery of Moskowitz. Based on these data, clinical...
Tipo: Journal article
Palavras-chave: Anatomic variation; Blood supply; Pancreas; Large intestine.
Ano: 2014
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000100032

Gestational Diabetes Reduces Pancreatic Beta Cells in Rat Offspring
Provedor de dados: 77
Autores: Moharerri,Alireza; Ghafari,Soraya; Golalipour,Mohammad Jafar.
Previous study has shown the adverse effects of gestational diabetes on hippocampal and spinal cord neuronal density in animal model. This study was conducted to determine the effect of gestational diabetes on beta cells in rat pancreas in early postnatal life. In this experimental study, 10 dams randomly allocated into control and diabetic groups on day 1 of gestation. Five dams in diabetic group received 40 mg/kg/BW of streptozotocin (intraperitoneally) and control animals received normal saline. Six of 28 and 56-day-old offspring of each gestational diabetes mellitus and controls were randomly scarified and sections were taken from the pancreas and stained using Gomorra's method. The density of beta cells and number and area of pancreatic islets were...
Tipo: Journal article
Palavras-chave: Gestational diabetes; Beta cell; Pancreas; Offspring; Rat.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000400034

Ethanol Intake and Toxicity: In Search of New Treatments
Provedor de dados: 77
Autores: Sandoval,Cristian; Vásquez,Bélgica; Mandarim-de-Lacerda,Carlos; del Sol,Mariano.
Prolonged alcohol consumption has consequences on the liver, producing necrotic precipitates and fibrosis, on the pancreas, causing the pancreatic acini to atrophy and destroying insulin-producing cells, and on the central nervous system (CNS), causing the gray and white matter in the frontal lobes of the brain and cerebellum to atrophy. Generally, alcohol is metabolized via oxidative pathways, where the enzymes alcohol dehydrogenase and aldehyde dehydrogenase participate during its metabolization in the liver and CNS, or via non-oxidative pathways during its metabolization in the pancreas. Ethanol metabolism can produce oxidative stress and tissue damage mediated by free radicals, causing morphological and functional alterations in the liver. In the...
Tipo: Journal article
Palavras-chave: Antioxidants; Ethanol; Liver; Pancreas; Central nervous system.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000300024

Effects of Ischemia/Reperfusion on ß Cells of Pancreas and Protective Effects of Melatonin Treatment
Provedor de dados: 77
Autores: Yildirim,Ayse  ; Tuncer,Mehmet Cudi; Pamukçu,Özlem  ; Aktas  ,Ayfer  ; Akkus,Murat  .
Oxygen free radicals are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia-reperfusion (I/R). In this study, we investigated the putative protective effects of melatonin treatment on pancreatic I/R injury. Sprague Dawley male rats were subjected to 30 min of pancreatic pedicle occlusion followed by 90 min reperfusion. Melatonin (10 mg/kg. s.c) was administrated 30 min prior to ischemia or I/R application. At the end of the reperfusion periods, rats were decapitated. Pancreatic samples were taken for transmission electron microscopy. The results indicated that ischemia created b cell damage as evidenced by dilatation between the nucleus inner and outer membrane and degeneration on islets of...
Tipo: Journal article
Palavras-chave: Pancreas; SS cells; Melatonin; Ischemia; Reperfusion.
Ano: 2009
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000200036

Multiple Vascular Anomalies in the Abdomen: A Gross Anatomical Study
Provedor de dados: 77
Autores: Jacob,Tony; Modgil,Vishal; Rana,Kum Kum; Das,Srijit.
Knowledge of the branching pattern of the abdominal aorta is clinically important for any abdominal surgeon operating on parts of the gut or neighboring structures like the suprarenals, spleen, pancreas, liver, kidneys and uréter. The presence of abnormal inferior phrenic artery associated with aberrant branch from the celiac trunk supplying the pancreas and duodenum is a rare anomaly. In the present case, we observed four branches of the celiac artery i.e. (a) left gastric artery (b) common hepatic artery (c) splenic artery and (d) an aberrant branch, which took a course inferiorly towards the pancreas. The aberrant artery supplied the body of the pancreas and gave a branch which supplied the horizontal part of the duodenum and then entered the transverse...
Tipo: Journal article
Palavras-chave: Anomaly; Celiac trunk; Branch; Inferior phrenic; Artery; Pancreas; Duodenum.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022008000300009

Effects of Aspartame on the Exocrine Pancreas of Rat Fetuses
Provedor de dados: 77
Autores: Leme,Fabíola Azevedo Genovez de Lima; Azoubel,Reinaldo.
The present study evaluated the effects of the sweetener aspartame on the fetal pancreas, through a morphometric study, with the objective of studying the exocrine pancreas at the end of gestational development. For this we utilized two treated groups, one with a solution of aspartame at ambient temperature and the other with an aspartame solution heated to 40C, and two groups treated with water ad libitum, at ambient temperature and heated to 40C, respectively. On the final day of gestation the fetuses were removed and the pancreas was collected for microscopic analysis. The morphometric study demonstrated alteration in eight out of the eleven parameters studied in the group treated with the heated solution and one parameter altered in the group treated...
Tipo: Journal article
Palavras-chave: Aspartame; Pancreas; Fetus.
Ano: 2006
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000500027

Proliferation of the b -Cells of Pancreas in Diabetic Rats Treated with Urtica Dioica
Provedor de dados: 77
Autores: Golalipour,Mohammad Jafar; Ghafari,Soraya; Kouri,Vahid; Kestkar,Abbas Ali.
This investigation was carried out to evaluate the effect of the extract of Urtica dioica leaves on hyperglycemia and quantitative changes of b-cells in streptozotocin-diabetic rats. Forty male Wistar rats were allocated in groups of normal, diabetic, treatment and protective. Hyperglycemia induced by administrating one dose of 80 mg/kg streptozotocin (STZ) intraperitoneally. Animals in treatment group received Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally, one week after injection of STZ. In protective group animals received U. dioica (100 mg/kg/day) for 5 days before inducing diabetes. After five weeks the animals were sacrificed and whole pancreas removed. Pancreas specimens were used for quantitative morphometric analysis after Chromealum...
Tipo: Journal article
Palavras-chave: Streptozotocin; Diabetes; Urtica dioica; Rat; Pancreas; B-cells; Blood glucose.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200011

A Classic Case of Annular Pancreas and its Clinical Implications
Provedor de dados: 77
Autores: Nayak B,Satheesha; Mun Yooi,Ooi.
Annular pancreas is a rare developmental anomaly where the head of the pancreas surrounds the second part of the duodenum like a ring. This may cause the duodenal constriction, obstruction, peptic ulcers and other complications. We saw a classic case of annular pancreas. The head of pancreas surrounded the second part of duodenum completely. However there was no narrowing of the duodenum. The case may be of importance for gastroenterologists, surgeons and radiologists.
Tipo: Journal article
Palavras-chave: Pancreas; Annular pancreas; Duodenum; Anomaly.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022011000200043

Effects of STZ-Induced Diabetes on the Relative Weights of Kidney, Liver and Pancreas in Albino Rats: A Comparative Study
Provedor de dados: 77
Autores: Zafar,Muhammad; Naeem-ul-Hassan Naqvi,Syed.
We studied the effects of streptozotocin (STZ)-induced diabetes on the body weights of animals and the relative weights of kidney, liver and pancreas in albino rats. The aim of the study was to find an association between the reduction in the body weights of diabetic animals and the relative weights of kidney, liver and pancreas in proportion to the body weight of animals in albino rats. This study was performed in the Department of Anatomy and Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi and Pathology department of College of Physicians &amp;amp; Surgeons (CPSP) Pakistan in 2007-08. Diabetes was induced by a single dose of STZ (45 mg/kg, b.w.) given intraperitoneally in sodium citrate buffer at pH 4.5. Eighty albino rats were...
Tipo: Journal article
Palavras-chave: STZ-diabetes; Body weights; Weight of kidney; Liver; Pancreas; Rats.
Ano: 2010
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000100019

Polysplenia syndrome with duodenal and pancreatic dysplasia in a Holstein calf : A case report
Provedor de dados: 19
Autores: Kondoh, Daisuke; Kawano, Tomomi; Kikuchi, Tomoaki; Hatate, Kaoru; Watanabe, Kenichi; Sasaki, Motoki; Yamagishi, Norio; Inokuma, Hisashi; Kitamura, Nobuo.
Background: Laterality disorders of the abdominal organs include situs inversus totalis that mirrors the arrangements of all internal organs and heterotaxy syndrome (situs ambiguus) in which the thoracic or abdominal organs are abnormally arranged. Heterotaxy is often accompanied by multiple congenital malformations, and it generally comprises asplenia and polysplenia syndromes. To our knowledge, polysplenia syndrome has been reported in only three cattle, and computerized tomographic (CT) images of these animals were not obtained. Case presentation: A six-month-old Holstein heifer had ruminal tympani and right abdominal distension. CT imaging showed that the rumen occupied the right side of the abdominal cavity, the omasum and abomasum occupied the left...
Palavras-chave: Cattle; Duodenum; Dysplasia; Heterotaxy; Laterality disorder; Malposition; Pancreas; Polysplenia.
Ano: 2017
URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4563

Malignant pancreatic gastrinoma in a maned wolf (Chrysocyon brachyurus): case report
Provedor de dados: 45
Autores: Carvalho,T.F.; Frois,D.N.; Tinoco,H.P.; Pessanha,A.T.; Paixão,T.A.; Santos,R.L.
ABSTRACT A captive 12-year-old female maned wolf (Chrysocyon brachyurus), previously diagnosed with visceral leishmaniasis, developed severe myiasis in the right ear, followed by prostration and death. A firm solid nodule, measuring 1 x 3cm, was grossly observed in the pancreas. Histologically, there was neoplastic proliferation in the pancreas and pancreatic lymph node. Neoplastic cells had a neuroendocrine pattern, and were positive for gastrin and pancreatic polypeptide by immunohistochemistry. The wolf had also ulcerative gastritis. To the best of our knowledge is the first reported case gastrinoma in this species.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Maned wolf; Chrysocyon brachyurus; Neoplasia; Pancreas; Gastrinoma.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352018000200475

Histomorphological and quantitative immunohistochemical changes in the rat pancreas during aging
Provedor de dados: 47
Autores: Riccillo,F.L.; Bracamonte,M.I.; Cónsole,G.M.; Gómez Dumm,C.L.A.
Although the endocrine pancreas is the purpose of several deep investigations, morphological data referred to the effect of aging on the gland are not homogeneous. The purpose of the current work was to analyze the changes occurring in the pancreas of aged rats, with especial reference to the islet cell populations. Six young (Y), old (O) and senescent (S) male Sprague-Dawley rats were used. The pancreas tails were processed for light microscopy and studied by means of routine stains as well as by immunohistochemical identification of insulin-, glucagon-, somatostatin-, and pancreatic polypeptide- secreting cells (Dako Envision System, DAB as chromogen). A progressive pancreatic histoarchitecture distortion was found among the aged animals. Even when the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Aging; Pancreas; Islets; Immunohistochemistry; Morphometry.
Ano: 2004
URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452004000200001

Pancreatic nitric oxide and oxygen free radicals in the early stages of streptozotocin-induced diabetes mellitus in the rat
Provedor de dados: 56
Autores: González,E.; Roselló-Catafau,J.; Jawerbaum,A.; Sinner,D.; Pustovrh,C.; Vela,J.; White,V.; Xaus,C.; Peralta,C.; Gimeno,M.
The objective of the present study was to explore the regulatory mechanisms of free radicals during streptozotocin (STZ)-induced pancreatic damage, which may involve nitric oxide (NO) production as a modulator of cellular oxidative stress. Removal of oxygen species by incubating pancreatic tissues in the presence of polyethylene glycol-conjugated superoxide dismutase (PEG-SOD) (1 U/ml) produced a decrease in nitrite levels (42%) and NO synthase (NOS) activity (50%) in diabetic but not in control samples. When NO production was blocked by N G-monomethyl-L-arginine (L-NMMA) (600 µM), SOD activity increased (15.21 ± 1.23 vs 24.40 ± 2.01 U/mg dry weight). The increase was abolished when the NO donor, spermine nonoate, was added to the incubating medium (13.2 ±...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Streptozotocin diabetes; Pancreas; Oxidative stress; Nitric oxide.
Ano: 2000
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000001100012

Microencapsulation and tissue engineering as an alternative treatment of diabetes
Provedor de dados: 56
Autores: Maria-Engler,S.S.; Mares-Guia,M.; Correa,M.L.C.; Oliveira,E.M.C.; Aita,C.A.M.; Krogh,K.; Genzini,T.; Miranda,M.P.; Ribeiro,M.; Vilela,L.; Noronha,I.L.; Eliaschewitz,F.G.; Sogayar,M.C.
In the 70's, pancreatic islet transplantation arose as an attractive alternative to restore normoglycemia; however, the scarcity of donors and difficulties with allotransplants, even under immunosuppressive treatment, greatly hampered the use of this alternative. Several materials and devices have been developed to circumvent the problem of islet rejection by the recipient, but, so far, none has proved to be totally effective. A major barrier to transpose is the highly organized islet architecture and its physical and chemical setting in the pancreatic parenchyma. In order to tackle this problem, we assembled a multidisciplinary team that has been working towards setting up the Human Pancreatic Islets Unit at the Chemistry Institute of the University of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Human pancreatic islets; Pancreas; Extracellular matrix; Stem cells; Islet microencapsulation; Transplantation; Ductal cells.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000600001

Metabolic dysregulation in early onset psychiatric disorder before and after exposure to antipsychotic drugs
Provedor de dados: 60
Autores: Shah,Rehmat; Subhan,Fazal; Sultan,Syed Muhammad; Haq,Matiul; Ahmad,Hussain; Khan,Qasim Riaz; Ali,Gowhar; Ullah,Sami; Ullah,Ihsan.
Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes mellitus. The study was designed to assess various biochemical parameters including insulin and blood sugar before and after exposure to APDs in order to exclude the involvement of psychiatric disorders and certain other factors in metabolic dysregulations. Fifty seven APDs-naïve patients with first episode psychosis were divided into six groups who received olanzapine, quetiapine, risperidone, aripiprazole, haloperidol or combination of olanzapine with...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Olanzapine; Quetiapine; Risperidone; Antipsychotics; Pancreas; Insulin.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100535

Short-term oral administration of risperidone induces pancreatic damage and hyperamylasemia in Sprague-dawley rats
Provedor de dados: 60
Autores: Shah,Rehmat; Subhan,Fazal; Sultan,Syed Muhammad; Ali,Gowhar.
Risperidone is an atypical antipsychotic acting mainly as a dopamine D2 and serotonin 5-HT2 receptors antagonist prescribed in the treatment of schizophrenia and various affective disorders. Risperidone has been reported to be associated with weight gain, panreatitis and type 2 diabetes mellitus. Various mechanisms of risperidone-induced toxicities have been reported but the histology of tissues especially pancreas has never been studied. Therefore, the current study was designed to elucidate the toxic effects of chronic administration of risperidone on pancreas, liver and kidneys. Animals (rats) of either gender were divided into two groups, the risperidone and control groups. Risperidone was administered in a dose of 2.5 mg/kg/d for three weeks. The...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Risperidone/antipsychotics/oral administration/effects; Histopathology; D2 antagonist; Pancreas.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000400629

Pancreatic beta cell protection/regeneration with phytotherapy
Provedor de dados: 60
Autores: Hosseini,Azar; Shafiee-Nick,Reza; Ghorbani,Ahmad.
Although currently available drugs are useful in controlling early onset complications of diabetes, serious late onset complications appear in a large number of patients. Considering the physiopathology of diabetes, preventing beta cell degeneration and stimulating the endogenous regeneration of islets will be essential approaches for the treatment of insulin-dependent diabetes mellitus. The current review focused on phytochemicals, the antidiabetic effect of which has been proved by pancreatic beta cell protection/regeneration. Among the hundreds of plants that have been investigated for diabetes, a small fraction has shown the regenerative property and was described in this paper. Processes of pancreatic beta cell degeneration and regeneration were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Diabetes mellitus/treatment; Diabetes mellitus/phytotherapy; Phytotherapy/Diabetes mellitus; Islets/endogenous regeneration; Beta cells/protection; Beta cells/regeneration; Pancreas; Medicinal plants/regenerative properties.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502015000100001