Consulta: subjectFacets:"Prepulse inhibition"
Registros recuperados: 1
Data/hora: 11/06/2024 17:17:05

Routine post-weaning handling of rats prevents isolation rearing-induced deficit in prepulse inhibition
Provedor de dados: 56
Autores: Rosa,M.L.N.M.; Silva,R.C.B.; Moura-de-Carvalho,F.T.; Brandão,M.L.; Guimarães,F.S.; Del Bel,E.A.
Rats reared under isolation conditions from weaning present a number of behavioral changes compared to animals reared under social conditions (group housing). These changes include deficits in prepulse inhibition (PPI) of the startle reflex to a loud sound. PPI refers to the reduction of the magnitude of the startle reflex when a relatively weak stimulus (the prepulse) precedes by an appropriate time interval the intense startle-elicing stimulus (the pulse). PPI is useful for studying sensorimotor integration. The present study evaluated the effect of handling on the impairment of PPI induced by isolation-rearing. Male Wistar rats (N = 11-15/group) were housed in groups (5 per cage and handled three times a week) or isolated (housed individually) since...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Stress; Rat; Schizophrenia; Social isolation; Prepulse inhibition; Locomotor activity.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005001100018