Consulta: subjectFacets:"Protein degradation"
Registros recuperados: 5
Data/hora: 10/06/2024 07:51:11

Plant arginyltransferases (ATEs)
Provedor de dados: 74
Autores: Domitrovic,Tatiana; Fausto,Anna K.; Silva,Tatiane da F.; Romanel,Elisson; Vaslin,Maite F. S.
Abstract Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One important enzyme involved in this process is arginyl-t-RNA transferase, known as ATE. This enzyme acts post-translationally by introducing an arginine residue at the N-terminus of specific protein targets to signal degradation via the UPS. However, the function of ATEs has only recently begun to be revealed. Nonetheless, the few studies to date investigating ATE activity in plants points to the great...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: ATE; N-end rule; Plant; Argyniltransferase; Protein degradation.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572017000200253

Optimal feedback strategies for bacterial growth with degradation, recycling, and effect of temperature
Provedor de dados: 5
Autores: Yegorov, Ivan; Mairet, Francis; Gouze, Jean-luc.
Mechanisms of bacterial adaptation to environmental changes are of great interest for both fundamental biology and engineering applications. In this work, we consider a continuous-time dynamic problem of resource allocation between metabolic and gene expression machineries for a self-replicating prokaryotic cell population. In compliance with evolutionary principles, the criterion is to maximize the accumulated structural biomass. In the model, we include both the degradation of proteins into amino acids and the recycling of the latter (ie, using as precursors again). On the basis of the analytical investigation of our problem by Pontryagin's maximum principle, we develop a numerical method to approximate the switching curve of the optimal feedback control...
Tipo: Text
Palavras-chave: Bacterial growth; Chattering regime; Effect of temperature; Feedback strategy; Optimal control; Pontryagin's maximum principle; Protein degradation; Recycling; Resource allocation; Singular regime; Switching curve.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00434/54592/56057.pdf

Short-term creatine supplementation changes protein metabolism signaling in hindlimb suspension
Provedor de dados: 56
Autores: Marzuca-Nassr,G.N.; Fortes,M.A.S.; Guimarães-Ferreira,L.; Murata,G.M.; Vitzel,K.F.; Vasconcelos,D.A.A.; Bassit,R.A.; Curi,R.
The effect of a short-term creatine supplementation on hindlimb suspension (HS)-induced muscle atrophy was investigated. Creatine monohydrate (5 g/kg b.w. per day) or placebo, divided in 2 daily doses, was given by oral gavage for 5 days. Rats were maintained in HS with dietary supplementation concomitantly for 5 days. Body weight, soleus and EDL muscle masses, and cross-sectional areas (CSA) of the muscle fibers were measured. Signaling pathways associated with skeletal muscle mass regulation (FST, MSTN, FAK, IGF-1, MGF, Akt, mTOR, atrogin-1, and MuRF1 expressions, and Akt, S6, GSK3B, and 4EBP1 proteins) were evaluated in the muscles. Soleus muscle exhibited more atrophy than the EDL muscle due to HS. Creatine supplementation attenuated the decrease of...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Creatine supplementation; Hindlimb suspension; Muscle disuse atrophy; Protein synthesis; Protein degradation.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2019001000606

Myostatin promotes distinct responses on protein metabolism of skeletal and cardiac muscle fibers of rodents
Provedor de dados: 56
Autores: Manfredi,L.H.; Paula-Gomes,S.; Zanon,N.M.; Kettelhut,I.C.
Myostatin is a novel negative regulator of skeletal muscle mass. Myostatin expression is also found in heart in a much less extent, but it can be upregulated in pathological conditions, such as heart failure. Myostatin may be involved in inhibiting protein synthesis and/or increasing protein degradation in skeletal and cardiac muscles. Herein, we used cell cultures and isolated muscles from rats to determine protein degradation and synthesis. Muscles incubated with myostatin exhibited an increase in proteolysis with an increase of Atrogin-1, MuRF1 and LC3 genes. Extensor digitorum longus muscles and C2C12 myotubes exhibited a reduction in protein turnover. Cardiomyocytes showed an increase in proteolysis by activating autophagy and the ubiquitin proteasome...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Myostatin; Skeletal muscle; Cardiomyocytes; Protein degradation; Protein synthesis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200604

Ruminal Degradability of Dry Matter and Crude Protein from Moist Dehulled Lupin and Extruded Rapeseed Meal
Provedor de dados: 117
Autores: Barchiesi-Ferrari,Claudia; Anrique,René.
The flow of ruminal undegradable protein (RUP) to the small intestine can be increased if ruminal degradation of dietary protein is reduced. The objective of this study was to evaluate the effect of extrusion on ruminal degradability of dry matter (DM) and crude protein (CP) from dehulled lupin (Lupinus albus L.) (DL) and rapeseed (Brassica napus L.) meal (RM). Unextruded soybean (Glicine max L.) meal (SBM) was used as a control. The DL was extruded at 130 ºC with 20% moisture and RM was extruded at 120 ºC with 20% moisture. Ruminal degradability was evaluated in situ by incubating feed samples for 2, 4, 8, 12, 24, and 48 h of fermentation in the rumen using three rumen-fistulated dairy cows. Values of CP soluble fraction (“a”) in SBM, DL, extruded...
Tipo: Journal article
Palavras-chave: Extrusion; Protein supplements; Protein degradation; Soybean meal; Cattle.
Ano: 2011
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0718-58392011000300014