Consulta: subjectFacets:"Quercetin"
Registros recuperados: 21
Data/hora: 17/06/2024 13:07:43

Quercetin Inhibits Left Ventricular Dysfunction Induced by Chronic Stress in Rats
Provedor de dados: 77
Autores: Bin-Jaliah,Ismaeel.
Complications of chronic stress including cardiovascular disease are among the common public health problems that affect the lives of millions of people around the globe. We sought to determine whether the anti-oxidant and anti-apoptotic agent, quercetin can inhibit chronic stress-induced left ventricular dysfunction (LVD). Chronic unpredictable stress (CUS) was induced in rats using a variety of stressors in the presence and absence of quercetin (50 mg/kg body weight/day). Harvested tissues from the left ventricles (LV) of these animals were examined using basic histological staining. In addition, LV tissue homogenates were assayed for markers of oxidative and anti-oxidative stress that are known to be modulated in cardiac dysfunction. Furthermore, LV...
Tipo: Journal article
Palavras-chave: Quercetin; Chronic stress; Heart failure; Left ventricular dysfunction; Antioxidant; Apoptosis.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000200044

Effects of Quercetin-Supplementation in NADH-Diaphorase Positive Neurons Subpopulations in the Ileum of Rats with Experimental Diabetes Mellitus
Provedor de dados: 77
Autores: Pereira Alves,Angela Maria; de Paula,Anderson Luiz; Moreira,Cassio Rafael; Ferrari,Fernanda; Coelho Leal,Jean Paulo; Hatoum,Ualid Saleh; Vieira Silva,Helaine Maruska; Belato Alves,Eder Paulo; de Miranda Neto,Marcilio Hubner; Galvanini,Paulo Alexandre.
The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparations of the muscular layer of the ileum underwent NADH-d histochemistry for evidencing the NADH-d neuronal subpopulation. Quantitative analyzes were performed on 30 random fields, and morphometric analyzes in 100 neuronal bodies and nuclei per animal. The supplementation promoted a 44 % reduction in the neuronal density in D group when compared to N group (p &lt;0.001); a 24.5 % reduction was observed in the DQ group when compared to N (p &lt;0.01). Animals in...
Tipo: Journal article
Palavras-chave: Diabetes mellitus; Enteric neurons; Quercetin; NADH diaphorase.
Ano: 2017
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022017000100039

Phenolic Compounds with Allelopathic Potential of Secale cereale L. and Raphanus sativus L. Grown Under an Agroecological No-Tillage System
Provedor de dados: 87
Autores: SOUZA,M.; COMIN,J.J.; KURTZ,C.; LOVATO,P.E.; LIMA,A.P.; KUHNEN,S.
ABSTRACT: The identification of compounds with allelopathic potential produced by cover crops can assist in selecting species for weed management purposes in no-tillage systems. This study aimed to identify the main phenolic compounds with allelopathic potential in the shoot of rye (Secale cereale L.) and oilseed radish (Raphanus sativus L.) cover crops, as well as evaluate whether the cultivation system and phenological stage may influence secondary metabolite production and weed emergence. Samples of the shoot of these cover crops were collected at 60, 80, and 100 days after sowing (DAS) and 15 and 30 days after lodging (DAL) under field conditions. Weed emergence was evaluated at 45, 75, and 100 DAL of cover crops. The main compounds in rye were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cover crops; Allelopathy; Quercetin; BOA; MBOA.
Ano: 2019
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-83582019000100287

The Effects of Dietary Flavonoid Supplementation on the Antioxidant Status of Laying Hens
Provedor de dados: 89
Autores: Iskender,H; Yenice,G; Dokumacioglu,E; Kaynar,O; Hayirli,A; Kaya,A.
ABSTRACT Ninety-six 28-week-old Lohmann White laying hens were utilized to test the antioxidant effects of flavonoids (hesperidin, naringin, and quercetin at 0.5 g/kg diet) during an 8-wk experimental period. At the end of the experiment blood samples were collected to determine total protein, cholesterol, and malondialdehyde (MDA) serum levels as well as activities of glutathione reductase (GR), glutathione peroxidase (GSH-Px), glutathione-S-transferase (GST), and superoxide dismutase (SOD) and level of glutathione (GSH) in erythrocyte lysates. Data were analyzed using one-way ANOVA. Naringin supplementation did not alter serum cholesterol concentration, whereas hesperidin and quercetin supplementations decreased serum cholesterol concentration. Naringin...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Antioxidant; Flavonoid; Hesperidin; Naringin; Quercetin.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2016000400663

Influence of Moringa Oleifera Leaf Meal Used as Phytogenic Feed Additive on the Serum Metabolites and Egg Bioactive Compounds in Commercial Layers
Provedor de dados: 89
Autores: Ahmad,S; Khalique,A; Pasha,TN; Mehmood,S; Ahmad,S Sohail; Khan,AM; Hussain,K.
ABSTRACT Phytogenic feed additives have been increasingly used in the last decade, and several plants and their metabolites have been investigated for the said purpose. In this context, present study aimed at evaluating the effects of Moringa oleifera as feed additive on layer performance, and egg bioactive compound levels and nutrient profile. HyLine W36 layers (n=200), 50 weeks of age, were randomly distributed in four treatments with five replicates of ten birds each. Four isocaloric (2725 kcal/kg) and isonitrogenous (CP 16%) diets were formulated and supplemented with 0, 0.5, 1.0, or 1.5% (w/w) of dried Moringa oleifera leaf powder (MLM). The results showed positive effects of MLM on egg production, egg mass, and feed conversion ratio, but negative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Β-carotene; Moringa leaf; Quercetin; Production performance; Serum biochemistry.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-635X2018000200325

Achyrocline satureioides (Lam.) DC. (marcela) reduces brain damage in permanent focal ischemia in rats
Provedor de dados: 98
Autores: Rivera Megret,Felicia; Tejera Correa,Dario; Abin Carriquiri,Juan Andrés; Prunell dos Santos,Giselle; Martínez Busi,Marcela; Dajas Méndez,Federico.
Introduction: Achyrocline satureioides is a plant which has been widely used in popular medicine and experimental studies confirm its antioxidant and anti-inflammatory effects, attributable to the presence of flavonoids, mainly quercetin. Objectives: to evaluate the neuroprotective effects of a chronic oral pre-administration to rats with an Achyrocline satureioides decoction (2 %). Methods: for decoction, dried flowers of Achyrocline satureioides were used. The consumption of food and AS decoction/water of the rats was evaluated daily and weight gain weekly; quercetin content in the decoction and in the plasma of the rats was evaluated by high performance liquid chromatography. The cerebral damage was assessed with a tetrazolium salt (TTC) and a...
Tipo: Journal article
Palavras-chave: Achyroclines satureioides; Quercetin; Permanent focal ischemia.
Ano: 2013
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962013000300011

Drying kinetics and quality of Cissus quadrangularis Linn. dried by convective hot air
Provedor de dados: 111
Autores: Jongyingcharoen, Jiraporn Sripinyowanich.
This research aimed to develop a suitable drying model of convective hot air drying of Cissus quadrangularis Linn. (CQ), determine the effective moisture diffusivity of the drying process and the activation energy of CQ, and investigate the effects of different drying temperatures (40, 60, 80, and 100°C) on energy consumption and quality of dried CQ. The generalized linear-plus-exponential-type model proposed in this study could be used to describe the moisture data of hot air drying of CQ satisfactorily with an R2 of 0.9957. The effective moisture diffusivity was in the range of 0.7302-9.1281 ×10-9 m2/s. a positive relationship was observed between this parameter and drying temperature. The activation energy of CQ was 39.78 kJ/mol. The lowest energy...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cissus quadrangularis; Hot air drying; Drying kinetic; Drying model; Quercetin.
Ano: 2020
URL: http://www.cigrjournal.org/index.php/Ejounral/article/view/5663

Enhanced biosynthesis of quercetin occurs as A photoprotective measure in Lycopersicon esculentum mill. under Acute UV-B exposure
Provedor de dados: 52
Autores: Shourie,Abhilasha; Tomar,Pushpa; Srivastava,Deepika; Chauhan,Rahul.
Lycopersicon esculentum respond to UV-B by enhanced synthesis of flavonoid quercetin, a strong antioxidant that helps the plants to well acclimatize to UV-B stress. Three weeks old plants of L. esculentum were subjected to acute UV-B irradiation for 20, 40 and 60 minutes daily until 28 days and analyzed for the morphological and biochemical changes. UV-B exposure for 40 and 60 minutes considerably affected the growth and biomass of L. esculentum. The leaves were deformed, developed chlorosis and abscised early as compared to the unexposed plants. Biomass declined by 35% and total chlorophyll decreased by 24.7% due to disintegration of chloroplasts. Enhancement was seen in the content of carotenoids, anthocyanins and total flavonoids by 15, 33.3 and 22.8%,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: UV-B; Lycopersicon esculentum; Quercetin; Biomass; Pigments; Anthocyanins.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300002

Anti-Quorum Sensing Potential of Antioxidant Quercetin and Resveratrol
Provedor de dados: 52
Autores: Erdönmez,Demet; Rad,Abbas Yousefi; Aksöz,Nilüfer.
ABSTRACT Quorum sensing system plays an active role in the regulation of pathogenicity of many microorganisms. Inhibition of pathogenicity or virulence factors will increase the success of treatment by preventing the development of antibiotic resistance. In this study, anti-quorum sensing activities of quercetin and resveratrol compounds, which have antioxidant property without damaging to host, have been determined via using biosensor bacteria: Chromobacterium violaceum ATCC 12472 and Chromobacterium violaceum CV026. As quorum sensing inhibitors, quercetin and resveratrol's cutting off the bacterial communication will prevent the treatment failures caused by the development of bacterial resistance. The development of layered drugs with antioxidant...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Anti-quorum sensing; Resveratrol; Quercetin; Antioxidant.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132018000100403

Effect of flavonoids morin; quercetin and nicotinic acid on lipid metabolism of rats experimentally fed with triton
Provedor de dados: 52
Autores: Ricardo,Kelly Fabiane Santos; Oliveira,Tânia Toledo de; Nagem,Tanus Jorge; Pinto,Aloisio da Silva; Oliveira,Maria Goreti Almeida; Soares,José Francisco.
Atherosclerosis is a coronary disease where deposition of lipids in the arteries leads to problems of blood circulation. The present work evaluates the action of the flavonoids morin, quercetin and nicotinic acid isolated in association on lipid metabolism in hyperlipidemic rats. Blood serum levels cholesterol, cholesterol-HDL, and triacylglycerids have been analysed following the intraperitoneal administration of the flavonoid compounds dissolved in propyleneglycol by in doses of 5mg/kg body weight. Quercetin presented the largest percentual reduction of cholesterol. The best results for cholesterol-HDL have been obtained with-nicotinic acid alone while morin-nicotinic acid combination showed the best triacylglycerols results. Results showed that...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Morin; Quercetin; Nicotinic Acid; Lipid; Cholesterol; Cholesterol-HDL; Triacylglycerols; Rats; Hyperlipidemic.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132001000300007

Hepatoprotective Effect of Quercetin Pretreatment Against Paracetamol-Induced Liver Damage and Partial Hepatectomy in Rats
Provedor de dados: 52
Autores: Barros,Pedro Paulo; Silva,Gustavo Henrique da; Gonçalves,Gisele Mara Silva; Oliveira,Jessica Cristiane; Pagnan,Livia Gonçalves; Arco-e-Flexa,Luiza.
ABSTRACT Quercetin has potent antioxidant action and a hepatoprotective role. The aim of this study was to evaluate the hepatoprotective action of quercetin pretreatment in paracetamol-induced liver damage (PILD) and structural injury resulting from partial hepatectomy (PH). In the first model, Wistar rats received oral quercetin (50mg/kg/day) during 8 days. On the 8th day, 3g/kg paracetamol were added. In the second model, the same quercetin dose was given during 7 days and rats were submitted to PH on the 8th day. Blood samples were obtained for determination of enzyme levels. Liver, heart, kidney and lung tissue were also collected for assessment of quercetin biodistribution and/or histological analyses. The results obtained after PILD were more...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quercetin; Paracetamol; Partial hepatectomy; ALT; AST.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132017000100302

Neuroprotection by flavonoids
Provedor de dados: 56
Autores: Dajas,F.; Rivera-Megret,F.; Blasina,F.; Arredondo,F.; Abin-Carriquiry,J.A.; Costa,G.; Echeverry,C.; Lafon,L.; Heizen,H.; Ferreira,M.; Morquio,A.
The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and neurodegeneration in particular. Flavonoids can protect the brain by their ability to modulate intracellular signals promoting cellular survival. Quercetin and structurally related flavonoids (myricetin, fisetin, luteolin) showed a marked cytoprotective capacity in in vitro experimental conditions in models of predominantly apoptotic death such as that induced by medium concentrations (200 µM) of H2O2 added to PC12 cells in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Flavonoids; Quercetin; Focal ischemia; Neuroprotection.
Ano: 2003
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2003001200002

Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome
Provedor de dados: 56
Autores: Li,X.; Chen,Y.; Wang,L.; Shang,G.; Zhang,C.; Zhao,Z.; Zhang,H.; Liu,A.
Quercetin shows protective effects against hepatopulmonary syndrome (HPS), as demonstrated in a rat model. However, whether these effects involve pulmonary vascular angiogenesis in HPS remains unclear. Therefore, this study aimed to assess the effect of quercetin on pulmonary vascular angiogenesis and explore the underlying mechanisms. Male Sprague-Dawley rats weighing 200-250 g underwent sham operation or common bile duct ligation (CBDL). Two weeks after surgery, HIF-1α and NFκB levels were assessed in rat lung tissue by immunohistochemistry and western blot. Then, CBDL and sham-operated rats were further divided into 2 subgroups each to receive intraperitoneal administration of quercetin (50 mg/kg daily) or 0.2% Tween for two weeks: Sham (Sham+Tween;...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Angiogenesis; Hepatopulmonary syndrome; HIF-1α; Quercetin.
Ano: 2016
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2016000700606

A combination of methylprednisolone and quercetin is effective for the treatment of cardiac contusion following blunt chest trauma in rats
Provedor de dados: 56
Autores: Demir,F.; Güzel,A.; Katı,C.; Karadeniz,C.; Akdemir,U.; Okuyucu,A.; Gacar,A.; Özdemir,S.; Güvenç,T.
Cardiac contusion is a potentially fatal complication of blunt chest trauma. The effects of a combination of quercetin and methylprednisolone against trauma-induced cardiac contusion were studied. Thirty-five female Sprague-Dawley rats were divided into five groups (n=7) as follows: sham, cardiac contusion with no therapy, treated with methylprednisolone (30 mg/kg on the first day, and 3 mg/kg on the following days), treated with quercetin (50 mg·kg−1·day−1), and treated with a combination of methylprednisolone and quercetin. Serum troponin I (Tn-I) and tumor necrosis factor-alpha (TNF-α) levels and cardiac histopathological findings were evaluated. Tn-I and TNF-α levels were elevated after contusion (P=0.001 and P=0.001). Seven days later, Tn-I and TNF-α...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Blunt chest trauma; Cardiac contusion; Quercetin; Methylprednisolone; INOS.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000900766

Inhibitory effect of liposomal quercetin on acute hepatitis and hepatic fibrosis induced by concanavalin A
Provedor de dados: 56
Autores: Wan,Y.; Tang,M.H.; Chen,X.C.; Chen,L.J.; Wei,Y.Q.; Wang,Y.S.
Immune response plays an important role in the development of hepatic fibrosis. In the present study, we investigated the effects of quercetin on hepatitis and hepatic fibrosis induced by immunological mechanism. In the acute hepatitis model, quercetin (2.5 mg/kg) was injected iv into mice 30 min after concanavalin A (Con A) challenge. Mice were sacrificed 4 or 24 h after Con A injection, and aminotransferase tests and histopathological sections were performed. Treatment with quercetin significantly decreased the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Consistent with this observation, treatment with quercetin markedly attenuated the pathologic changes in the liver. A hepatic fibrosis model was also generated in mice...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quercetin; Concanavalin A; Acute hepatitis; Hepatic fibrosis; Liposome.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000800655

Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
Provedor de dados: 56
Autores: Wang,Y.; Zhang,Z.Z.; Wu,Y.; Ke,J.J.; He,X.H.; Wang,Y.L.
Quercetin (Que), a plant-derived flavonoid, has multiple benefical actions on the cardiovascular system. The current study investigated whether Que postconditioning has any protective effects on myocardial ischemia/reperfusion (I/R) injury in vivo and its potential cardioprotective mechanisms. Male Sprague-Dawley rats were randomly allocated to 5 groups (20 animals/group): sham, I/R, Que postconditioning, Que+LY294002 [a phosphatidylinositol 3-kinase (PI3K)/Akt signaling pathway inhibitor], and LY294002+I/R. I/R was produced by 30-min coronary occlusion followed by 2-h reperfusion. At the end of reperfusion, myocardial infarct size and biochemical changes were compared. Apoptosis was evaluated by both TUNEL staining and measurement of activated caspase-3...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ischemia and reperfusion; Quercetin; Postconditioning; PI3K/Akt.
Ano: 2013
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001000861

Selection of filamentous fungi of the Beauveria genus able to metabolize quercetin like mammalian cells
Provedor de dados: 58
Autores: Costa,Eula Maria de M. B.; Pimenta,Fabiana Cristina; Luz,Wolf Christian; Oliveira,Valéria de.
Microbial biotransformations constitute an important alternative as models for drug metabolism study in mammalians and have been used for the industrial synthesis of chemicals with pharmaceutical purposes. Several microorganisms with unique biotransformation ability have been found by intensive screening and put in commercial applications. Ten isolates of Beauveria sp genus filamentous fungi, isolated from soil in the central Brazil, and Beauveria bassiana ATCC 7159 were evaluated for their capability of quercetin biotransformation. Biotransformation processes were carried out for 24 up to 96 hours and monitored by mass spectrometry analyses of the culture broth. All strains were able to metabolize quercetin, forming mammalian metabolites. The results were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Beauveria bassiana; Biotransformation; Quercetin.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822008000200036

In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L.
Provedor de dados: 58
Autores: Jesus,Roberta S.; Piana,Mariana; Freitas,Robson B.; Brum,Thiele F.; Alves,Camilla F.S.; Belke,Bianca V.; Mossmann,Natália Jank; Cruz,Ritiel C.; Santos,Roberto C.V.; Dalmolin,Tanise V.; Bianchini,Bianca V.; Campos,Marli M.A.; Bauermann,Liliane de Freitas.
Abstract The main objective of this study was to demonstrate the antimicrobial potential of the crude extract and fractions of Chenopodium ambrosioides L., popularly known as Santa-Maria herb, against microorganisms of clinical interest by the microdilution technique, and also to show the chromatographic profile of the phenolic compounds in the species. The Phytochemical screening revealed the presence of cardiotonic, anthraquinone, alkaloids, tannins and flavonoids. The analysis by HPLC-DAD revealed the presence of rutin in the crude extract (12.5 ± 0.20 mg/g), ethyl acetate (16.5 ± 0.37 mg/g) and n-butanol (8.85 ± 0.11 mg/g), whereas quercetin and chrysin were quantified in chloroform fraction (1.95 ± 0.04 and 1.04 ± 0.01 mg/g), respectively. The most...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Amaranthaceae; Antimicrobial potential; Rutin; Quercetin; Chrysin.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000200296

Quercetin: a flavonoid with the potential to treat asthma
Provedor de dados: 60
Autores: Fortunato,Laila Rigolin; Alves,Claudiney de Freitas; Teixeira,Maxelle Martins; Rogerio,Alexandre Paula.
Allergic asthma is a complex inflammatory disorder characterized by airway hyperresponsiveness, eosinophilic inflammation and hypersecretion of mucus. Current therapies include β2-agonists, cysteinyl leukotriene receptor 1 antagonists and corticosteroids. Although these drugs demonstrate beneficial effects, their adverse side effects limit their long-term use. Thus, the development of new compounds with similar therapeutic activities and reduced side effects is both desirable and necessary. Natural compounds are used in some current therapies, as plant-derived metabolites can relieve disease symptoms in the same manner as allopathic medicines. Quercetin is a flavonoid that is naturally found in many fruits and vegetables and has been shown to exert...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Quercetin; Flavonoids; Asthma.
Ano: 2012
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502012000400002

In silico pharmacodynamics, toxicity profile and biological activities of the Saharan medicinal plant Limoniastrum feei
Provedor de dados: 60
Autores: Ammar,Ouahab.
ABSTRACT In-silico study was performed to find the pharmacodynamics, toxicity profiles and biological activities of three phytochemicals isolated from Limoniastrum feei (Plumbagenaceae). Online pharmacokinetic tools were used to estimate the potential of Quercetin, kaempferol-3-O-β-D-glucopyranoside (astragalin) and quercitin-7-O-β-D-glucopyranoside as specific drugs. Then the prediction of potential targets of these compounds were investigated using PharmMapper. Auto-Dock 4.0 software was used to investigate the different interactions of these compounds with the targets predicted earlier. The permeability of quercetin was found within the range stated by Lipinski ׳s rule of five. Hematopoietic prostaglandin (PG) D synthase (HPGDS), farnesyl diphosphate...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Limoniastrum feei/pharmacokinetics; Limoniastrum feei/biological activity; Quercetin; Astragalin; Quercetin 7; Medicinal plants; Molecular docking.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000300606

Determination of phytoconstituents of n-hexane extract of leaves of Morus nigra and evaluation of their effects on biochemical and histopathological parameters in paracetamol intoxicated mice liver
Provedor de dados: 60
Autores: Mallhi,Tauqeer Hussain; Qadir,Muhammad Imran; Khan,Yusra Habib.
In-vitro investigation of Morus nigra L. (Moraceae) has demonstrated the evidence of several antioxidant compounds. Current study was aimed to determine the phytoconstituents and hepatoprotective potential of n-hexane extract of Morus nigra. Swiss albino mice were divided into five groups: normal control, paracetamol control, silymarin control, 250 mg/kg p.o. extract for 7 days plus paracetamol 3 h later, 500 mg/kg p.o. extract for 7 days plus paracetamol 3 h later. Serum levels of liver enzymes and total bilirubin were assessed and compared between the groups by using one-way ANOVA to confirm hepatoprotective activity. HPLC analysis revealed the presence quercetin, oleanolic acid, luteolin, apigenin, vitamin C and kuwanon C. n-hexane extract of Morus...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Moraceae; HPLC; Quercetin; Morus nigra/antioxidant; Morus nigra/extract/hepatoprotective.
Ano: 2018
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502018000300631