Consulta: subjectFacets:"Radiobiocomplex"
Registros recuperados: 4
Data/hora: 01/06/2024 01:06:34

The ingestión of a Nectandra membranácea extract changes the bioavailability of technetium-99m radiobiocomplex in rat organs
Provedor de dados: 48
Autores: RAMOS FARÍAS MORENO,SILVANA; ARNOBIO,ADRIANO; CARVALH0,JORGE JOSÉ DE; NASCIMENT0,LUCIA; OLIVEIRA TIMOTEO,MARGARETH; OLEJ,BENI; KAZAN ROCHA,EMELY; PEREIRA,MARIO; BERNARDO-FILH0,MARIO; QUERINO DE ARAÚJO CALDAS,LUIZ.
The radiobiocomplexes labeled with technetium-99m (Tc-99m) have been widely used in nuclear medicine in single photon emission computed tomography and in basic research. The aim of this study was to assess the influence of a Nectandra membranácea extract on the bioavailability of the sodium pertechnetate (Na99mTc0(4)) radiobiocomplex in rat organs. The animals were treated with a N. membranácea extract (30 mg/ ml), for 6 days. Na99mTc0(4) was injected, the organs were isolated and weighed, and the radioactivity was determined in each organ (%ATI/organ). The %ATI/organ was divided by the mass of each organ to calculate the %ATI/g. A significant increase of the %ATI/organ of Na99mTc0(4) was observed in muscle and thyroid as well as in the %ATI/g in the...
Tipo: Journal article
Palavras-chave: Nectandra membranácea; Bioavailability; Sodium pertechnetate; Radiobiocomplex.
Ano: 2007
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200004

An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m
Provedor de dados: 52
Autores: Giani,Tania Santos; Paoli,Severo de; Presta,Giuseppe Antonio; Maiworm,Adalgisa Ieda; Santos-Filho,Sebastião David; Brandão-Neto,José; Medeiros,Aldo da Cunha; Fonseca,Adenilson de Souza da; Bernardo-Filho,Mario.
Buzhong Yi Qi Wan (Buzhong) is a medicinal herb widely used in Traditional Chinese Medicine to treat the digestive and circulatory systems. Red blood cell and plasma proteins labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to investigate the effects of an aqueous Buzhong extract on the labeling of blood constituents with 99mTc. Heparinized blood (Wistar rats) was incubated in vitro with different Buzhong extract concentrations and 99mTc-labeling was performed. Plasma (P) and blood cells (BC) were separated and soluble (SF-P, SF-BC) and insoluble (IF-P, IF-BC) fractions were isolated. The radioactivity on blood constituents was determined and the percentage of incorporated radioactivity (%ATI) was calculated....
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Technetium-99m; Red blood cell; Oxidant agent; Radiobiocomplex; Plasma proteins; Buzhong Yi Qi Wan.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000600013

Bioavailability of the sodium pertechnetate and morphometry of organs isolated from rats: study of possible pharmacokinetic interactions of a ginkgo biloba extract
Provedor de dados: 52
Autores: Moreno,Silvana Ramos Farias; Carvalho,Jorge José; Nascimento,Ana Lúcia; Pereira,Mário; Rocha,Emely Kazan; Diré,Gláucio; Arnobio,Adriano; Caldas,Luiz Querino de Araújo; Bernardo-Filho,Mario.
Many compounds affect the bioavailability of radiobiocomplexes as radiopharmaceuticals. Ginkgo Biloba extract (EGb) has several effects. The influence of an EGb on the bioavailability of the radiobiocomplex sodium pertechnetate (Na99mTcO4) and on the morphometry of the organs was evaluated. Rats were treated with EGb and Na99mTcO4 was injected. The animals were sacrificed; the radioactivity in the organs was counted. The results showed that EGb altered the Na99mTcO4 bioavailability in the kidneys, liver and duodenum. Morphometric analysis of the organs showed significant alterations (P&lt;0.05), probably caused by metabolites generated by EGb and capable of altering the bioavailability of the Na99mTcO4.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ginkgo biloba extract; Bioavailability; Radiobiocomplex; Sodium pertechnetate; Morphometry.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000700011

Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats
Provedor de dados: 56
Autores: Moreno,S.R.F.; Silva,A.L.C.; Diré,G.; Honeycut,H.; Carvalho,J.J.; Nascimento,A.L.; Pereira,M.; Rocha,E.K.; Oliveira-Timóteo,M.; Arnobio,A.; Olej,B.; Bernardo-Filho,M.; Caldas,L.Q.A.
The aim of the present study was to determine the effect of the oral ingestion of an extract of the herb Uncaria tomentosa (cat's claw) on the biodistribution of the radiobiocomplex sodium pertechnetate (Na99mTcO4) in rats. The animals (male Wistar rats, 2 months old, 180-220 g), were treated (1 mL) with an U. tomentosa extract (32 mg/mL, N = 5) or 0.9% NaCl solution (control, N = 5) for 7 days. After this period, Na99mTcO4 (3.7 MBq, 0.3 mL) was injected through the ocular plexus and after 10 min the rats were killed, the organs isolated and counted in a well-gamma counter. A significant (P &lt; 0.05) alteration in Na99mTcO4 uptake i) from 0.57 ± 0.008 to 0.39 ± 0.06 %ATI/organ (P &lt; 0.05) and from 0.57 ± 0.17 to 0.39 ± 0.14 %ATI/g (P &lt; 0.05) was...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Uncaria tomentosa; Biodistribution; Sodium pertechnetate; Radiobiocomplex.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100010