Consulta: subjectFacets:"Reelin"
Registros recuperados: 2
Data/hora: 12/06/2024 00:36:33

Schizophrenia and reelin: a model based on prenatal stress to study epigenetics, brain development and behavior
Provedor de dados: 48
Autores: Negrón-Oyarzo,Ignacio; Lara-Vásquez,Ariel; Palacios-García,Ismael; Fuentealba,Pablo; Aboitiz,Francisco.
Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive function that is mainly dependent on the prefrontal cortex. This behavioral deficit, together with cellular and neurophysiological alterations in the prefrontal cortex, as well as reduced density of GABAergic cells and aberrant oscillatory activity, all indicate structural and functional deficits of the prefrontal cortex in schizophrenia. Among the several risk factors for the development of schizophrenia, stress during the prenatal period has been identified as crucial. Thus, it is proposed that prenatal stress induces neurodevelopmental alterations in the...
Tipo: Journal article
Palavras-chave: Schizophrenia; Prefrontal cortex; Prenatal stress; Functional connectivity; DNA methylation; Reelin.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100016

Critical steps in the early evolution of the isocortex: Insights from developmental biology
Provedor de dados: 56
Autores: Aboitiz,F.; Montiel,J.; López,J.
This article proposes a comprehensive view of the origin of the mammalian brain. We discuss i) from which region in the brain of a reptilian-like ancestor did the isocortex originate, and ii) the origin of the multilayered structure of the isocortex from a simple-layered structure like that observed in the cortex of present-day reptiles. Regarding question i there have been two alternative hypotheses, one suggesting that most or all the isocortex originated from the dorsal pallium, and the other suggesting that part of the isocortex originated from a ventral pallial component. The latter implies that a massive tangential migration of cells from the ventral pallium to the dorsal pallium takes place in isocortical development, something that has not been...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Cdk5; Dorsal ventricular ridge; Reelin; Tangential migration; Ventral pallium.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001200006