Consulta: subjectFacets:"Regulatory motif"
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Data/hora: 10/06/2024 08:05:06

A biomolecular proportional integral controller based on feedback regulations of protein level and activity
Provedor de dados: 5
Autores: Mairet, Francis.
Homeostasis is the capacity of living organisms to keep internal conditions regulated at a constant level, despite environmental fluctuations. Integral feedback control is known to play a key role in this behaviour. Here, I show that a feedback system involving transcriptional and post-translational regulations of the same executor protein acts as a proportional integral (PI) controller, leading to enhanced transient performances in comparison with a classical integral loop. Such a biomolecular controller-which I call a level and activity-PI controller (LA-PI)-is involved in the regulation of ammonium uptake by Escherichia coli through the transporter AmtB. The P-II molecules, which reflect the nitrogen status of the cell, inhibit both the production of...
Tipo: Text
Palavras-chave: Homeostasis; Perfect adaptation; Regulatory motif; Transcriptional and post-translational regulations.
Ano: 2018
URL: https://archimer.ifremer.fr/doc/00434/54598/55968.pdf