Consulta: subjectFacets:"Sildenafil"
Registros recuperados: 6
Data/hora: 05/06/2024 12:38:40

Propolis Protective Role Against Morphological, Hormonal Biochemical and Histological Alterations Induced by Sildenafil Overdoses
Provedor de dados: 77
Autores: Almansour,Mansour; Jarrar,Yazun; Jarrar,Bashir.
Sildenafil is widely used for the treatment of erectile dysfunction with few studies are available on the protective role of propolis against its reproductive toxicity. The present study aims to investigate the hormonal biochemical and histomorphometric alterations induced in the testicular tissues by sildenafil overdoses. Four groups of rabbits were exposed to sildenafil with or without propolis as follows: Group I received the formulated vehicle, Group II received sildenafil (3 mg/kg), Group III received propolis (50 mg/kg), Group IV received sildenafil plus propolis. Sildenafil lowered body weight gain, testosterone and follicular stimulating hormone concentration but increased testis index while luteinizing hormone was almost not affected. Moreover,...
Tipo: Journal article
Palavras-chave: Propolis; Sildenafil; Testis; Histological alterations; Toxicity.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200020

Effects of Sildenafil on Dental Pulp: Immunohistochemical and Ultrastructural Evaluation
Provedor de dados: 77
Autores: Söker,Sevda; Deveci,Engin; Yaman,Ferhan; Atilgan,Serhat; Ipek,Fikret; Uysal,Ibrahim.
Sildenafil is a strong peripheral vasodilator and is used to treat cardiovascular and neurosurgery. The purpose of this study was to investigate the immunohistochemical and ultrastructural effects of sildenafil on dental pulp of rats. The study was performed with adult female Wistar-Albino rats. Control group (n= 7) were fed on standard laboratory diet until surgery. The study group (n= 7) were administered sildenafil orally with orogastric tube 10 mg·kg-1 once a day for 30 days. Each rat was anesthetized and incisor teeth were removed. This study examined the immunohistochemical and ultrastructural effects of sildenafil on the dental pulp in rats. The relaxation from the vessel, endothelial cell hyperplasia, moderate degeneration of collagen fibers were...
Tipo: Journal article
Palavras-chave: Sildenafil; Dental pulp; Morphological changes; Immunohistochemical study; Ultrastructural study.
Ano: 2016
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200025

Sildenafil delays the intestinal transit of a liquid meal in awake rats
Provedor de dados: 56
Autores: Graça,J.R.V; Macedo,G.M; Palheta Jr,R.C; Gondim,F. de A.A; Nogueira,R.O; Correia,J.M; Rola,F.H; Oliveira,R.B; Souza,M.A.N; Santos,A.A.
Sildenafil slows down the gastric emptying of a liquid test meal in awake rats and inhibits the contractility of intestinal tissue strips. We studied the acute effects of sildenafil on in vivo intestinal transit in rats. Fasted, male albino rats (180-220 g, N = 44) were treated (0.2 mL, iv) with sildenafil (4 mg/kg) or vehicle (0.01 N HCl). Ten minutes later they were fed a liquid test meal (99m technetium-labeled saline) injected directly into the duodenum. Twenty, 30 or 40 min after feeding, the rats were killed and transit throughout the gastrointestinal tract was evaluated by progression of the radiotracer using the geometric center method. The effect of sildenafil on mean arterial pressure (MAP) was monitored in a separate group of rats (N = 14). Data...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Intestinal transit; Mean arterial pressure; Scintigraphy; Sildenafil.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100012

Effect of sildenafil (Viagra®) on the genital reflexes of paradoxical sleep-deprived male rats
Provedor de dados: 56
Autores: Andersen,M.L.; Bignotto,M.; Tufik,S.
Since there is evidence that paradoxical sleep deprivation (PSD) elicits penile erection (PE) and ejaculation (EJ), and that the erectile response of rats is mediated by nitric oxide, the present study sought to extend the latter finding by assessing the effects of sildenafil on the genital reflexes of male Wistar rats subjected to PSD. We also determined the influence of sildenafil on hormone concentrations. In the first experiment, sildenafil at doses ranging from 0.08 to 0.32 mg/kg was administered intraperitoneally to rats that had been deprived of sleep for 4 days and to home cage controls (N = 8-10/group). The frequency of PE and EJ was measured for 60 min. PSD alone induced PE in 50% of the animals; however, a single injection of sildenafil did not...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Paradoxical sleep deprivation; Sildenafil; Genital reflexes; Dopamine; Testosterone; Progesterone.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001100008

Sildenafil prevents the increase of extravascular lung water and pulmonary hypertension after meconium aspiration in newborn piglets
Provedor de dados: 56
Autores: Silvera,F.E.; Blasina,M.F.; Vaamonde,L.; Tellechea,S.; Godoy,C.; Zabala,S.; Mañana,G.; Martell,M.; Olivera,W.
Meconium aspiration syndrome causes respiratory failure after birth and in vivo monitoring of pulmonary edema is difficult. The objective of the present study was to assess hemodynamic changes and edema measured by transcardiopulmonary thermodilution in low weight newborn piglets. Additionally, the effect of early administration of sildenafil (2 mg/kg vo, 30 min after meconium aspiration) on this critical parameter was determined in the meconium aspiration syndrome model. Thirty-eight mechanically ventilated anesthetized male piglets (Sus scrofa domestica) aged 12 to 72 h (1660 ± 192 g) received diluted fresh human meconium in the airway in order to evoke pulmonary hypertension (PHT). Extravascular lung water was measured in vivo with a PiCCO monitor and...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Lung water; Meconium aspiration syndrome; Newborn; Sildenafil; Pulmonary hypertension.
Ano: 2011
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000800007

One-year follow-up of the effects of sildenafil on pulmonary arterial hypertension and veno-occlusive disease
Provedor de dados: 56
Autores: Barreto,A.C.; Franchi,S.M.; Castro,C.R.P.; Lopes,A.A.
We hypothesized that chronic oral administration of the phosphodiesterase-5 inhibitor sildenafil could improve the exercise capacity and pulmonary hemodynamics in patients with pulmonary arterial hypertension (PAH) on the basis of previous short-term studies. We tested this hypothesis in 14 subjects with PAH, including seven patients with the idiopathic form and seven patients with atrial septal defects, but no other congenital heart abnormalities. Patients were subjected to a 6-min walk test and dyspnea was graded according to the Borg scale. Pulmonary flow and pressures were measured by Doppler echocardiography. Patients were given sildenafil, 75 mg orally three times a day, and followed up for 1 year. Sildenafil therapy resulted in the following...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sildenafil; Pulmonary hypertension; Pulmonary veno-occlusive disease; Phosphodiesterase inhibitors.
Ano: 2005
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000200006