Consulta: subjectFacets:"Sleep deprivation"
Registros recuperados: 11
Data/hora: 01/06/2024 00:57:21

Comparative transcriptome analysis of the hippocampus from sleep-deprived and Alzheimer’s disease mice
Provedor de dados: 74
Autores: Wei,Yi.
Abstract We did a comparative analysis of the gene expression profiles of the hippocampus from sleep deprivation and Alzheimer’s disease (AD) mice. Differentially expressed genes (DEGs) were identified by comparing the transcriptome profiles of the hippocampus of sleep deprivation or AD mouse models to matched controls. The common DEGs between sleep deprivation and AD were identified by the overlapping analysis, followed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The results showed that a total of 16 common DEGs showed similar change patterns in both sleep deprivation mice and AD mice. Sgk1, Ly6a, Atp6v0e, Hspb8, Htra1, Pdk4, Pfkfb3, Golm1, and Plin3 were up-regulated in the two disorders, whereas, Marcksl1, Fgd1,...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep deprivation; Alzheimer’s disease; Hippocampus; Acetyl-CoA; Lipid.
Ano: 2020
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000400703

Paradoxical sleep deprivation: neurochemical, hormonal and behavioral alterations. Evidence from 30 years of research
Provedor de dados: 42
Autores: Tufik,Sergio; Andersen,Monica L.; Bittencourt,Lia R. A.; Mello,Marco T. de.
Sleep comprises approximately one-third of a person's lifetime, but its impact on health and medical conditions remains partially unrecognized. The prevalence of sleep disorders is increasing in modern societies, with significant repercussions on people's well-being. This article reviews past and current literature on the paradoxical sleep deprivation method as well as data on its consequences to animals, ranging from behavioral changes to alterations in the gene expression. More specifically, we highlight relevant experimental studies and our group's contribution over the last three decades.
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Sleep deprivation; Rebound; Dopamine; Erection; Corticosterone; Memory.
Ano: 2009
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652009000300016

Stress and sleep quality in high school brazilian adolescents
Provedor de dados: 42
Autores: Mesquita,Gema; Reimão,Rubens.
OBJECTIVE: The objective of the present study is to analyze the effect of stress on sleep quality in a group of adolescents. METHOD: Two high schools in Alfenas, southern Minas Gerais State, Brazil, were chosen to participate in the study. The sample consisted of both genders (n=160) with 65.63% females. The age range of participants was 15 to18 years. The Pittsburgh Sleep Quality Index (PSQI) was applied for collection of data to quantify sleep quality. The Lipp Inventory of Stress Symptoms that objectively identifies symptoms of stress was applied. RESULTS: It was observed that 23.53% of stressed students and 45.33% of unstressed ones sleep well; 76.47% of stressed pupils and 54.67% of those unstressed do not sleep well. With regard to school...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep; Sleep disorders; Stress; Sleep deprivation; Psychological symptoms.
Ano: 2010
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652010000200029

On-line analysis of biosignals for the automation of total and specific sleep deprivation in the rat
Provedor de dados: 48
Autores: VIVALDI,ENNIO A; BASSI,ALEJANDRO; ESTRADA,JORGE; GARRIDO,IGNACIO; DÍAZ,JAVIER; OCAMPO-GARCÉS,ADRIÁN.
A computer-based system that automates sleep studies, including sleep deprivation paradigms, is described. The system allows for total or REM-specific sleep deprivation and is based on a reliable, fast-responding, on-line state detection algorithm linked to a dependable intervention device. Behavioral state detection is achieved by dimensión reduction of short-term EEG power spectrum. Interventions are made by serial outputs to servomotors that move a cage with different patterns and variable intensity. The system can adapt itself to individual characteristics and to changes in recording conditions. Customized protocols can be designed by defining the states or stages to be deprived, including scheduling temporal patterns. A detailed analysis of the...
Tipo: Journal article
Palavras-chave: Sleep; Sleep deprivation; Biosignal analysis; Digital control; Automation.
Ano: 2008
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000400009

Sleep-wake pattern of medical students: early versus late class starting time
Provedor de dados: 56
Autores: Lima,P.F.; Medeiros,A.L.D.; Araujo,J.F.
The sleep-wake cycle of students is characterized by delayed onset, partial sleep deprivation and poor sleep quality. Like other circadian rhythms, the sleep-wake cycle is influenced by endogenous and environmental factors. The aim of the present study was to determine the effects of different class starting times on the sleep-wake pattern of 27 medical students. The data were collected during two medical school semesters having different class starting times. All subjects answered the Portuguese version of the Horne and Östberg Morningness/Eveningness Questionnaire, the Pittsburgh Sleep Quality Index (PSQI) and kept a sleep diary for two weeks during each semester. Better sleep quality (PSQI = 5.3 vs 3.4), delayed sleep onset (23:59 vs 0:54 h) and longer...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sleep-wake cycle; Class schedule; Sleep quality; Sleep deprivation.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002001100016

Fighting by sleep-deprived rats as a possible manifestation of panic: effects of sodium lactate
Provedor de dados: 56
Autores: Furlan,F.A.; Hoshino,K.
Increased fighting is an effect of desynchronized sleep deprivation (DSD) in rats, and recently this behavior has been suggested to be spontaneous panic and equivalent to panic disorder. In the present study we tested this hypothesis by evaluating the effect of sodium lactate on this aggressiveness, because this substance is recognized to induce spontaneous panic attacks in patients. A total of 186 male albino Wistar rats, 250-350 g, 90-120 days of age, were submitted to DSD (multiple platform method) for 0, 4, or 5 days. At the end of the deprivation period the rats were divided into subgroups respectively injected intraperitoneally with 1.86, 2.98 and 3.72 g/kg of 1 M sodium lactate, or 1.86 and 3.72 g/kg of 2 M sodium lactate. The control animals were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Rat; Sleep deprivation; Panic; Aggressiveness; Sodium lactate.
Ano: 2001
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000300010

Paradoxical sleep deprivation increases plasma endothelin levels
Provedor de dados: 56
Autores: Palma,B.D.; Gabriel Jr.,A.; Bignotto,M.; Tufik,S.
The endothelins (ET-1, 2 and 3) constitute a family of 21 amino acid peptides with potent biological activities. ET-1 is one of the most potent endogenous vasoconstrictors so far identified and its increased concentration in plasma appears to be closely related to the pathogenesis of arterial hypertension as well as to obstructive sleep apnea (OSA). OSA patients exhibit repetitive episodes of apnea and hypopnea that result in hypoxia and consecutive arousals. These patients are chronically sleep deprived, which may aggravate the hypertensive features, since literature data show that sleep deprivation results in hypertension both in humans and in animals. Based on the reported relationship between ET-1, hypertension and sleep deprivation consequences, the...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Endothelin; Sleep deprivation; Rat; Hypertension.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100011

Sleep deprivation reduces the lymphocyte count in a non-obese mouse model of type 1 diabetes mellitus
Provedor de dados: 56
Autores: Ruiz,F.S.; Andersen,M.L.; Zager,A.; Martins,R.C.S.; Tufik,S.
The objective of the present study was to determine whether sleep deprivation (SD) would promote changes in lymphocyte numbers in a type 1 diabetes model (non-obese diabetic, NOD, mouse strain) and to determine whether SD would affect female and male NOD compared to Swiss mice. The number of lymphocytes in peripheral blood after 24 and 96 h of SD (by multiple platform method) or equivalent period of time in home-cage controls was examined prior to the onset of diabetes. SD for 96 h significantly reduced lymphocytes in male Swiss mice compared to control (8.6 ± 2.1 vs 4.1 ± 0.7 10³/µL; P &lt; 0.02). In male NOD animals, 24- and 96-h SD caused a significant decrease of lymphocytes compared to control (4.4 ± 0.3 vs 1.6 ± 0.5; P &lt; 0.001 and 4.4 ± 0.3 vs 0.9...
Tipo: Info:eu-repo/semantics/other
Palavras-chave: Sleep deprivation; Stress; Lymphopenia; Diabetes; Non-obese diabetic mouse; Swiss mice.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000500005

Effects of cocaine, methamphetamine and modafinil challenge on sleep rebound after paradoxical sleep deprivation in rats
Provedor de dados: 56
Autores: Martins,R.C.S; Andersen,M.L; Shih,M.C; Tufik,S.
Sleep loss is both common and critically relevant to our society and might lead to the abuse of psychostimulants such as amphetamines, cocaine and modafinil. Since psychoactive substance abuse often occurs within a scenario of sleep deficit, the purpose of this investigation was to compare the sleep patterns of rats challenged with cocaine (7 mg/kg, ip), methamphetamine (7 mg/kg, ip), or modafinil (100 mg/kg, ip) subsequent to paradoxical sleep deprivation (PSD) for 96 h. Our results show that, immediately after 96 h of PSD, rats (10 per group) that were injected with a psychostimulant presented lower percentages of paradoxical sleep compared to those injected with saline (P &lt; 0.01). Regarding slow wave sleep (SWS), rats injected with psychostimulants...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep deprivation; Sleep; Cocaine; Methamphetamine; Modafinil; Rebound; Dopamine.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000100011

Gentle handling temporarily increases c-Fos in the substantia nigra pars compacta
Provedor de dados: 56
Autores: Santos,C.A.; Andersen,M.L.; Lima,M.M.S.; Tufik,S.
Dopaminergic neurotransmission is involved in the regulation of sleep. In particular, the nigrostriatal pathway is an important center of sleep regulation. We hypothesized that dopaminergic neurons located in substantia nigra pars compacta (SNpc) could be activated by gentle handling, a method to obtain sleep deprivation (SD). Adult male C57/BL6J mice (N = 5/group) were distributed into non-SD (NSD) or SD groups. SD animals were subjected to SD once for 1 or 3 h by gentle handling. Two experiments were performed. The first determined the activation of SNpc neurons after SD, and the second examined the same parameters after pharmacologically induced dopaminergic depletion using intraperitoneal reserpine (2 mg/kg). After 1 or 3 h, SD and NSD mice were...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sleep deprivation; Dopamine; C-Fos; Substantia nigra pars compacta; Gentle handling of mice.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008001000015

Sawtooth waves during REM sleep after administration of haloperidol combined with total sleep deprivation in healthy young subjects
Provedor de dados: 56
Autores: Pinto Jr.,L.R.; Peres,C.A.; Russo,R.H.; Remesar-Lopez,A.J.; Tufik,S.
We sought to examine the possible participation of dopaminergic receptors in the phasic events that occur during rapid eye movement (REM) sleep, known as sawtooth waves (STW). These phasic phenomena of REM sleep exhibit a unique morphology and, although they represent a characteristic feature of REM sleep, little is known about the mechanisms which generate them and which are apparently different from rapid eye movements. STW behavior was studied in 10 male volunteers aged 20 to 35 years, who were submitted to polysomnographic monitoring (PSG). On the adaptation night they were submitted to the first PSG and on the second night, to the basal PSG. On the third night the volunteers received placebo or haloperidol and spent the whole night awake. On the...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Sawtooth waves; REM sleep; Sleep deprivation; Dopaminergic receptors; Rapid eye movements; Haloperidol.
Ano: 2002
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500013