Consulta: subjectFacets:"Sodium phytate"
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Data/hora: 05/06/2024 04:42:28

Biodistribution of the radiopharmaceutical technetium-99m-sodium phytate in rats after splenectomy
Provedor de dados: 52
Autores: Pereira,Kércia Regina Santos Gomes; Açucena,Maria Kadja Meneses Torres; Villarim Neto,Arthur; Rêgo,Amália Cínthia Meneses; Bernardo-Filho,Mário; Azevedo,Ítalo Medeiros; Araújo Filho,Irami; Medeiros,Aldo Cunha.
Drugs and surgery can interfere with the biodistribution of radiopharmaceuticals and data about the effect of splenectomy on the metabolism of phytate-Tc-99m are scarce. This study aimed at evaluating the interference of splenectomy on phytate-Tc-99m biodistribution and liver function in rats. The SP group rats (n=6) underwent splenectomy. In group C (control) the animals were not operated on. After 15 days, all rats were injected with 0.1mL of Tc-99m-phytate via orbital plexus (0.66MBq). After 30 minutes, liver samples were harvested, weighed and the percentage of radioactivity per gram (%ATI/g) was determined by a Wizard Perkin-Elme gama counter. The ATI%/g in splenectomized rats (0.99±0.02) was significantly higher than in controls (0.4±0.02),...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Splenectomy; Sodium phytate; Biodistribution; Liver.
Ano: 2008
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132008000700033