Consulta: subjectFacets:"Ulcerative colitis"
Registros recuperados: 7
Data/hora: 01/06/2024 05:58:40

Efecto de Rhizophora mangle L. sobre colitis ulcerativa experimental en ratas
Provedor de dados: 98
Autores: Sánchez Perera,Luz María; Batista,Niurka Yasmin; Gálvez,Julio; Duran,Reina; Bulnes,Carlos.
INTRODUCCIÓN: Rhizophora mangle L. es una planta de gran distribución en Cuba, de la cual se han demostrado científicamente efectos sobre las úlceras gastroduodenales, cicatrizantes, antiinflamatorios, antioxidantes, así como elevada absorción intestinal; por lo que podría poseer actividad sobre colitis ulcerativa. OBJETIVOS: establecer el efecto del extracto acuoso seco de cortezas de R. mangle sobre colitis ulcerativa en 2 modelos experimentales en ratas. MÉTODOS: se realizó el estudio en los modelos de inducción de colitis ulcerativa por la administración intracolon de ácido acético, una previa oral de 3 niveles de dosis del extracto seco de 100, 250 y 500 mg/kg de masa corporal y 3 grupos con la administración intracolon de las dosis 24, 50 y 100 mg de...
Tipo: Journal article
Palavras-chave: Rhizophora mangle L; Colitis ulcerativa; Rhizophora mangle L; Ulcerative colitis.
Ano: 2009
URL: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1028-47962009000100007

Infrequent p53 gene alterations in ulcerative colitis
Provedor de dados: 56
Autores: Mattar,R.; Alexandrino,A.M.; Laudanna,A.A.
The purpose of this study was to determine whether point mutations and loss of the p53 gene take place in ulcerative colitis which is histologically negative for dysplasia. DNA was extracted from 13 frozen rectal or colon biopsies and blood samples. Ulcerative colitis was classified histologically as active (10 cases) and inactive (3 cases). Exons 5-8 were amplified by PCR, treated with exonuclease and shrimp alkaline phosphatase and sequenced by the dideoxy chain termination method with the Sequenase Version 2.0 DNA sequencing kit. PCR products of intron 6 and exon 4 were digested with MspI and AccII, respectively, for RFLP analysis. No p53 gene mutation was detected in these cases. The number of informative patients for loss of heterozygosity (LOH) at...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: P53 gene; Ulcerative colitis; LOH; Mutation.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000900005

Classical and recent advances in the treatment of inflammatory bowel diseases
Provedor de dados: 56
Autores: Sales-Campos,H.; Basso,P.J.; Alves,V.B.F.; Fonseca,M.T.C.; Bonfá,G.; Nardini,V.; Cardoso,C.R.B.
Crohn's disease (CD) and ulcerative colitis (UC) are intestinal disorders that comprise the inflammatory bowel diseases (IBD). These disorders have a significant effect on the quality of life of affected patients and the increasing number of IBD cases worldwide is a growing concern. Because of the overall burden of IBD and its multifactorial etiology, efforts have been made to improve the medical management of these inflammatory conditions. The classical therapeutic strategies aim to control the exacerbated host immune response with aminosalicylates, antibiotics, corticosteroids, thiopurines, methotrexate and anti-tumor necrosis factor (TNF) biological agents. Although successful in the treatment of several CD or UC conditions, these drugs have limited...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Treatment; Immune modulation; Cellular therapy.
Ano: 2015
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2015000200096

Bone mineral density and inflammatory bowel disease severity
Provedor de dados: 56
Autores: Lima,C.A.; Lyra,A.C.; Mendes,C.M.C.; Lopes,M.B.; Coqueiro,F.G.; Rocha,R.; Santana,G.O.
Inflammatory bowel disease (IBD) is associated with low bone mineral density (BMD). In this study, the association between disease severity and BMD in patients with IBD was evaluated. Associations between BMD and the Montreal classification, disease activity and drug therapy were also tested. A cross-sectional prevalence study with a comparison group was conducted. One hundred and twenty-eight patients were evaluated: 68 patients with ulcerative colitis (UC), and 60 with Crohn's disease (CD). The control group consisted of 67 healthy subjects. All patients and controls had BMD measured and in IBD patients, current medications, hospitalization, and disease location, extent and phenotype, according to the Montreal classification, were recorded. Multiple...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Bone mineral density; Ulcerative colitis; Crohn’s disease; Inflammatory bowel disease; Osteoporosis.
Ano: 2017
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017001200614

Enhanced mucosal re-epithelialization induced by short chain fatty acids in experimental colitis
Provedor de dados: 56
Autores: Aguilar-Nascimento,J.E.; França-da-Silva,L.R.; de-Oliveira,A.F.; Gomes-da-Silva,M.H.
The short chain fatty acids (SCFA) are the best nutrients for the colonocytes. Glucose is poorly used as a fuel but may be transformed into SCFA by colonic bacteria. The aim of this study was to investigate the effect of SCFA or glucose on experimental colitis. Colitis was induced in 30 Wistar rats by colonic instillation of 4% acetic acid. Five days later they were randomized to receive twice a day colonic lavage containing saline (controls, N = 10), 10% hypertonic glucose (N = 10) or SCFA (N = 10) until day 8 when they were killed. At autopsy, the colon was removed and weighed and the mucosa was evaluated macro- and microscopically and stripped out for DNA assay. Data are reported as mean ± SD or median [range] as appropriate. All animals lost weight but...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Short chain fatty acids; Ulcerative colitis; Glucose; Colon; Inflammation; Mucosa.
Ano: 1999
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1999000800005

Immunoexpression of cyclooxygenase-1 and -2 in ulcerative colitis
Provedor de dados: 56
Autores: Paiotti,A.P.R.; Artigiani Neto,R.; Forones,N.M.; Oshima,C.T.F.; Miszputen,S.J.; Franco,M.
Ulcerative colitis (UC) is a disease of the colon and rectum characterized by a nonspecific chronic inflammation mediated by the concerted response of cellular and humoral events. Prostaglandins are synthesized by cyclooxygenase (COX)-1 and -2 and exhibit both pro- and anti-inflammatory activity. To evaluate COX-1 and COX-2 immunoexpression in 42 cases of UC and to correlate it with clinicopathological parameters, COX-1 and COX-2 expression was investigated by the immunohistochemistry method. Only patients with all pertinent clinical and evolutive data as well as with adequate biopsy material were included in the study. Fifteen samples of colorectal adenocarcinoma and 14 of large bowel with no histological changes were used for positive and negative...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Ulcerative colitis; Cyclooxygenases; Prostaglandins; Immunohistochemistry.
Ano: 2007
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000700004

Association among genetic predisposition, gut microbiota, and host immune response in the etiopathogenesis of inflammatory bowel disease
Provedor de dados: 56
Autores: Basso,P.J.; Fonseca,M.T.C.; Bonfá,G.; Alves,V.B.F.; Sales-Campos,H.; Nardini,V.; Cardoso,C.R.B.
Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic disorder that affects thousands of people around the world. These diseases are characterized by exacerbated uncontrolled intestinal inflammation that leads to poor quality of life in affected patients. Although the exact cause of IBD still remains unknown, compelling evidence suggests that the interplay among immune deregulation, environmental factors, and genetic polymorphisms contributes to the multifactorial nature of the disease. Therefore, in this review we present classical and novel findings regarding IBD etiopathogenesis. Considering the genetic causes of the diseases, alterations in about 100 genes or allelic variants, most of them in...
Tipo: Info:eu-repo/semantics/article
Palavras-chave: Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Immune response; Etiology; Microbiota.
Ano: 2014
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000900727