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3-D modeling and molecular dynamics simulation of interleukin-22 from the So-iny mullet, Liza haematocheila Electron. J. Biotechnol.
Qi,Zhitao; Shi,Rongwei; Li,Suyang; Zang,Xiayan; Wang,Zisheng.
Background: Interleukin-22 (IL-22) plays an important role in the regulation of immune responses. However, little is known about its function or structure in fish. Results: The IL-22 gene was first cloned from So-iny mullet (Liza haematocheila), one of commercially important fish species in China. Then, 3-D structure model of the mullet IL-22 was constructed by comparative modeling method using human IL-22 (1M4R) as template, and a 5 ns molecular dynamics (MD) was studied. The open reading frame (ORF) of mullet IL-22 cDNA was 555 bp, encoding 184 amino acids. The mullet IL-22 shared higher identities with the other fish IL-22 homologs and possessed a conserved IL-10 signature motif at its C-terminal. The mullet IL-22 model possessed six conserved helix...
Tipo: Journal article Palavras-chave: Comparative modeling; Interleukin-22; Liza haematocheila; Molecular dynamics.
Ano: 2013 URL:
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