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In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates BJM
El-Nakeeb,Moustafa A; Abou-Shleib,Hamida M; Khalil,Amal M; Omar,Hoda G; El-Halfawy,Omar M.
Antihistaminics are widely used for various indications during microbial infection. Hence, this paper investigates the antimicrobial activities of 10 antihistaminics belonging to both old and new generations using multiresistant Gram-positive and Gram-negative clinical isolates. The bacteriostatic activity of antihistaminics was investigated by determining their MIC both by broth and agar dilution techniques against 29 bacterial strains. Azelastine, cyproheptadine, mequitazine and promethazine were the most active among the tested drugs. Diphenhydramine and cetirizine possessed weaker activity whereas doxylamine, fexofenadine and loratadine were inactive even at the highest tested concentration (1 mg/ml). The MIC of meclozine could not be determined as it...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antihistaminics; Bactericidal activity; Bacteriostatic activity; Gram-negative isolates; Gram-positive isolates.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300018
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Membrane permeability alteration of some bacterial clinical isolates by selected antihistaminics BJM
El-Nakeeb,Moustafa A; Abou-Shleib,Hamida M; Khalil,Amal M; Omar,Hoda G; El-Halfawy,Omar M.
Several antihistaminics possess antibacterial activity against a broad spectrum of bacteria. However, the exact mechanism of such activity was unclear. Hence, the aim of this study is to investigate their mechanism of antibacterial activity especially their effect upon the permeability of the bacterial cytoplasmic membrane. The effects of azelastine, cetirizine, cyproheptadine and diphenhydramine were studied using Gram-positive and Gram-negative multiresistant clinical isolates. Leakage of 260 and 280 nm UV-absorbing materials was detected upon treatment with the tested antihistaminics; indicative of membrane alteration. Using an artificial membrane model, cholesterol-free negatively-charged unilamellar liposomes, confirmed the effect of antihistaminics...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Antihistaminics; Azelastine; Bacteria; Cytoplasmic membrane; Liposomes; Permeability alteration.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822011000300019
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ラット後躯自己血液潅流標本における血管拡張反応の薬理学的特性 OAK
Nishimura, Masakazu; Su, Che; Lee, Tony J.-F.
Palavras-chave: Neurogenic vasodilation; Rat; Hindquarters; Antihistaminics; Cocaine.
Ano: 1996 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/1355
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