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Topical 1% Nalbuphine on corneal sensivity and epitheilization after experimental lamellar keratectomy in rabbits Ciência Rural
Silva,Miguel Ladino; Piso,Dunia Yisela Trujillo; Ribeiro,Alexandre Pinto; Laus,Jose Luiz.
The present study was aimed to evaluate the effects of topical 1% nalbuphine on corneal sensitivity and re-epithelialization, after lamellar keratectomy in rabbits. All protocols were approved by the Animal Care Comission of São Paulo State University (Protocol 028793-08) and were conducted in accordance with the Institutional Animal Committee and the Association for Research in Vision and Ophthalmology (ARVO) statement for the use of animals in research. Surgeries were performed on the left eye (Nalbuphine Group) and on the right eye (Control Group). Two groups were formed (n=10) and corneas received either 30µl of 1% nalbuphine (NG) or 30µl of 0,9% saline (CG). Treatments occurred at 7, 11, 15 and 19 hours. After the surgery, the corneas were stained...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rabbit; Cornea; Re-epithelialization; Nalbuphine; Pain.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782012000400017
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Evaluation of cytotoxicity and wound healing activity of Avicennia schaueriana in cream Anais da ABC (AABC)
LOPES,CAROLINE M.I.; BARATELLA-EVÊNCIO,LIRIANE; SOUZA,IVONE A. DE; OLIVEIRA,ERWELLY B. DE; SÁ,JÉSSICA G.A.; SANTANA,MARLLON A.N.; MARCELINO NETO,PEDRO P.; SANTANA,EDUARDA S. DE; SILVA,LUZIA A. DA; VIEIRA,JEYMESSON R.C..
Abstract:Avicennia schaueriana is found in Brazilian mangrove coast. The cytotoxicity in vitro of the Aqueous Extract of Leaves of Avicennia schaueriana (AELAs) and the healing activity of the plant in cream on mice skin wounds were evaluated in this study. The cytotoxic evaluation was performed on Vero cells. The healing activity was evaluated on mice treated during 5, 10 and 15 days with cream at 5%, solution of sodium chloride at 0.9% and dexpanthenol in cream at 5%. The extract did not show cytotoxicity, but showed mitogenic activity (100μg/ml). In morphometric analysis, the percentage of wound contraction after 10 days was higher in dexpanthenol group (93.41%). In 15 days, the lowest percentage of contraction was observed in the dexpanthenol group...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Avicennia schaueriana; In vitro techniques; Re-epithelialization; Vero cells; Wound healing.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100805
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