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From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases Anais da ABC (AABC)
FERREIRA,LEONARDO G.; OLIVA,GLAUCIUS; ANDRICOPULO,ADRIANO D..
ABSTRACT Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprecedentedly demanded the development of up-to-date computational approaches, such as bio- and chemo-informatics. These tools have been pivotal to catalyzing the ever-increasing amount of data generated by the molecular sciences, and to converting the data into insightful guidelines for use in the research pipeline. As a result, ligand- and structure-based drug design have emerged as key pathways to address the pharmaceutical industry’s striking demands for...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Medicinal chemistry; Ligand-based drug design; Structure-based drug design; Cancer; Neglected tropical diseases.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000200645
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Recent Advances and Perspectives in Cancer Drug Design Anais da ABC (AABC)
MAGALHAES,LUMA G.; FERREIRA,LEONARDO L.G.; ANDRICOPULO,ADRIANO D..
ABSTRACT Cancer is one of the leading causes of death worldwide. With the increase in life expectancy, the number of cancer cases has reached unprecedented levels. In this scenario, the pharmaceutical industry has made significant investments in this therapeutic area. Despite these efforts, cancer drug research remains a remarkably challenging field, and therapeutic innovations have not yet achieved expected clinical results. However, the physiopathology of the disease is now better understood, and the discovery of novel molecular targets has refreshed the expectations of developing improved treatments. Several noteworthy advances have been made, among which the development of targeted therapies is the most significant. Monoclonal antibodies and...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cancer; Targeted therapy; Cytotoxic therapy; Drug discovery.
Ano: 2018 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652018000301233
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