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Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents Biol. Res.
Fernandes,Hélio B; Silva,Francilene V; Passos,Flávia Franceli B; Bezerra,Roosevelt D S; Chaves,Mariana H; Oliveira,Francisco A; Meneses Oliveira,Rita C.
Parkia platycephala Benth. (Leguminosae - Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gastroprotective activity were obtained from the genus Parkia. Therefore, this study aimed at investigating the gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves (Pp-EtOH), as well as evaluating its possible mechanisms of action in experimental ulcer induction models. Lesions were induced by absolute ethanol, ethanol-HCl, ischemia-reperfusion and indomethacin in rodents. Pp-EtOH showed a protective effect in the lesion models (66, 48 and 52 %,...
Tipo: Journal article Palavras-chave: Antioxidant; Ethanol; Gastroprotection; Nitric oxide; Parkia platycephala; Ulcer.
Ano: 2010 URL:
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