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Fast and reliable calibration of solid substrate fermentation kinetic models using advanced non-linear programming techniques Electron. J. Biotechnol.
Araya,M. Macarena; Arrieta,Juan J; Pérez-Correa,J. Ricardo; Biegler,Lorenz T; Jorquera,Héctor.
Calibration of mechanistic kinetic models describing microorganism growth and secondary metabolite production on solid substrates is difficult due to model complexity given the sheer number of parameters needing to be estimated and violation of standard conditions of numerical regularity. We show how advanced non-linear programming techniques can be applied to achieve fast and reliable calibration of a complex kinetic model describing growth of Gibberella fujikuroi and production of gibberellic acid on an inert solid support in glass columns. Experimental culture data was obtained under different temperature and water activity conditions. Model differential equations were discretized using orthogonal collocations on finite elements while model calibration...
Tipo: Journal article Palavras-chave: Dynamic models; Gibberellic acid; Nonlinear models; Parameter estimation; Secondary metabolites; Solid substrate cultivation.
Ano: 2007 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582007000100005
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