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Endotoxin inhibits the surge secretion of gonadotropin-releasing hormone via a prostaglandin-independent pathway Inra
Breen, K.M.; Billings, H. J.; Debus, N.; Karsch, F. J..
Immune/inflammatory challenges, such as bacterial endotoxin, disrupt gonadotropin secretion and ovarian cyclicity. We previously determined that endotoxin can block the estradiol-induced LH surge in the ewe. Here, we investigated mechanisms underlying this suppression. First, we tested the hypothesis that endotoxin blocks the estradiol-induced LH surge centrally, by preventing the GnRH surge. Artificial follicular phases were created in ovariectomized ewes, and either endotoxin or vehicle was administered together with a surge-inducing estradiol stimulus. In each ewe in which endotoxin blocked the LH surge, the GnRH surge was also blocked. Given this evidence that endotoxin blocks the estradiol-induced LH surge at the hypothalamic level, we began to assess...
Tipo: Journal Article Palavras-chave: ENDOTOXINE; HORMONE GONADOTROPE; GONADOTROPINE; PROSTAGLANDINE; SECRETION DE LH; PULSE DE GNRH; CYCLE OVARIEN; HYPOTHALAMUS ENDOTOXIN; HORMONE; GONADOTROPIN; GNRH; LH.
Ano: 2004 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2007a6a7a3a2&uri=/notices/prodinra1/2008/09/
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