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Effect of watercress on induced DNA damage, DNA repair and p-glycoprotein activity in human lymphocytes JBAG
Casanova,N.A; Wagner,M.L; López Nigro,M.M; Carballo,M.A.
Cruciferae vegetables are widely studied due to their potential anticarcinogenic properties. In the present work we analyzed the antigenotoxic effect of watercress (Nasturtium officinale, W. Aiton), a member of this family. The vegetal was processed, and the juice obtained was evaluated in relation with genetic material protection and DNA repair capacity against two deleterious agents: mitomycin C and hydrogen peroxide. The antigenotoxic properties were analyzed through cytokinesis block micronucleus test and comet assay (standard and with endonuclease), respectively. Besides, we tested the functionality of P-glycoprotein in human lymphocytes exposed to the whole extract. Watercress had no effect on mitomycin cytostatic effect (p>0.05) and although...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chemopreventive effects; Comet assay; Micronucleus test; Transporters; Nasturtium officinale.
Ano: 2014 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S1852-62332014000300005
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