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Registros recuperados: 4
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Construction of a cytogenetically anchored microsatellite map in rabbit Inra
Chantry-Darmon, C.; Urien, C.; Hayes, H.; Bertaud, M.; Chadi, S.; Chardon, P.; Vaiman, D.; Rogel-Gaillard, C..
Rabbit (Oryctolagus cuniculus) represents a valuablesource of biomedical models and corresponds to asmall but active economic sector in Europe for meatand fur. The rabbit genome has not been thoroughlystudied until recently, and high-resolution mapsnecessary for identification of genes and quantitativetrait loci (QTL) are not yet available. Our aim was toisolate over 300 new and regularly distributed (TG)nor (TC)n rabbit microsatellites. To achieve thispurpose, 164 microsatellite sequences were isolatedfrom gene-containing bacterial artificial chromosome(BAC) clones previously localized by fluorescencein situ hybridization (FISH) on all the rabbitchromosomes. In addition, 141 microsatellite sequenceswere subcloned from a plasmid genomiclibrary, and for 41...
Tipo: Journal Article Palavras-chave: CARTE GENETIQUE; LAPIN; CARTE CYTOGENETIQUE.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20075d7b09fe&uri=/notices/prodinra1/2008/08/
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Expanded comparative mapping between man and rabbit and detection of a new conserved segment between HSA22 and OCU4 Inra
Chantry-Darmon, C.; Bertaud, M.; Urien, C.; Chadi, S.; PERROCHEAU, M.; Rogel-Gaillard, C.; Hayes, H..
Rabbit, a domestic species exploited both in animalproduction and medical research has only recently begunto be included in gene mapping projects, in particular by theFrench National Institute of Agronomics. By 2002, less than 60genes had been precisely localised on rabbit chromosomes,which led us to start a large-scale project on gene mapping inrabbit with the publication of 133 gene localisations in 2003(Chantry-Darmon et al., 2003). Here, we report the localisationof 102 new genes resulting in good coverage of the rabbitgenome and an eight-fold enrichment of the gene map. In addition,we have detected a new conserved segment between rabbitchromosome 4q15.3 and part of human chromosome 22 andthus improved the comparative map with the human genome.
Tipo: Journal Article Palavras-chave: CARTE GENETIQUE; GENETIQUE COMPAREE; LAPIN; HOMME.
Ano: 2005 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2007ee750b6e&uri=/notices/prodinra1/2008/08/
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R-spondin1 is required for normal epithelial morphogenesis during mammary gland development Inra
Chadi, S.; Buscara, L.; Péchoux, C.; Costa, J.; Laubier, J.; Chaboissier, M-C; Pailhoux, E.; Vilotte, J.L.; Chanat, E.; Le Provost, F..
The R-spondin (Rspo) proteins constitute a novel class of ligands that induce Wnt signalling. Rspo1 knockout XX mice were previously shown to be sex-reversed, but some remain sub-fertile. These last were unable to feed their pups for some unknown reason. Using these mice and transplanted mammary tissues from Rspo1(-/-) virgin mice in nude mice, we report that the lack of Rspo1 expression results in the absence of duct side-branching development and subsequent alveolar formation, explaining the above mentioned phenotype. Our data demonstrate that local epithelial Rspo1 signalling is required for normal development of the mammary gland.
Tipo: Journal Article Palavras-chave: MAMMARY GLAND; EPITHELIAL CELL; DEVELOPMENT; R-SPONDIN; DUCT FORMATION; GENE EXPRESSION.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD201088080799&uri=/notices/prodinra1/2010/05/
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Which PrP haplotypes in a French sheep population are the most susceptible to atypical scrapie ? Inra
Moreno, C.R.; Moazami-Goudarzi, K.; Laurent, P.; Cazeau, G.; Andréoletti, O.; Chadi, S.; Elsen, J.M.; Calavas, D..
A French sheep case control study has been organised to estimate the effects of the PrP haplotypes on resistance to atypical scrapie. The ALHQ and AFRQ haplotypes are significantly more susceptible than the others.
Tipo: Journal Article Palavras-chave: TREMBLANTE; ATYPIQUE; RESISTANCE; PRP; OVIN.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2007f93f51c0&uri=/notices/prodinra1/2010/10/
Registros recuperados: 4
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