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Registros recuperados: 11
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Changes in neurotransmitter levels and expression of immediate early genes in brain of mice infected with Neospora caninum OAK
Ihara, Fumiaki; Nishimura, Maki; Muroi, Yoshikage; Furuoka, Hidefumi; Yokoyama, Naoaki; Nishikawa, Yoshifumi.
Neospora caninum is an obligate intracellular parasite that causes neurological disorders in dogs and cattle. The majority of host animals are asymptomatic at the chronic stage of infection. However, it remains unclear whether cerebral function is normal in asymptomatic animals. In this study, mice were infected with N. caninum (strain Nc-1) and their brains were examined to understand changes in cerebral function at the chronic stage of infection. Mice infected with N. caninum showed impaired locomotor activity, but no differences in clinical symptoms were observed. In the brains of infected mice, parasites were distributed throughout the brain and histological lesions were observed everywhere except for the cerebellum. Expression levels of...
Ano: 2016 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4460
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Depletion of Phagocytic Cells during Nonlethal Plasmodium yoelii Infection Causes Severe Malaria Characterized by Acute Renal Failure in Mice OAK
Terkawi, Mohamad Alaa; Nishimura, Maki; Furuoka, Hidefumi.
In the current study, we examined the effects of depletion of phagocytes on the progression of Plasmodium yoelii 17XNL infection in mice. Strikingly, the depletion of phagocytic cells, including macrophages, with clodronate in the acute phase of infection significantly reduced peripheral parasitemia but increased mortality. Moribund mice displayed severe pathological damage, including coagulative necrosis in liver and thrombi in the glomeruli, fibrin deposition, and tubular necrosis in kidney. The severity of infection was coincident with the increased sequestration of parasitized erythrocytes, the systematic upregulation of inflammation and coagulation, and the disruption of endothelial integrity in the liver and kidney. Aspirin was administered to the...
Palavras-chave: Phagocytes; Macrophages; Phagocytosis; Plasmodium yoelii.
Ano: 2016 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/4479
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Effective antigen-retrieval method for immunohistochemical detection of abnormal isoform of prion proteins in animals OAK
Furuoka, Hidefumi; Yabuzoe, Atushi; Horiuchi, Motohiro; Tagawa, Yuichi; Yokoyama, Takashi; Yamakawa, Yoshio; Shinagawa, Morikazu; Sata, Tetsutaro.
For immunohistochemistry of the prion diseases, several pretreatment methods to enhance the immunoreactivity of human and animal abnormal proteinase-resistant prion protein (PrPSc) on the tissue sections have been employed. The method of 121 degrees C hydrated autoclaving pretreatment or the combination method of 121 degrees C hydrated autoclaving with a certain chemical reagent ( formic acid or proteinase K, etc) are now widely used. We found that an improved hydrated autoclaving method at 135 degrees C, more effectively enhanced PrPSc immunoreactivity for the antibodies recognizing the linear epitope. In addition, this method was more effective for the long-term fixation samples as compared with other previous methods. However, this modified method could...
Palavras-chave: Prion protein; Immunohistochemistry; Antigen retrieval; Autoclaving; Monoclonal antibody; CREUTZFELDT-JAKOB-DISEASE; MONOCLONAL-ANTIBODIES; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; PROTOCOLS; FIXATION; DEPOSITS; PLAQUES; BRAIN; PRP.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/712
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HSP70欠損牛の臨床学的・病理学的研究 OAK
古岡, 秀文; 佐藤, 基佳; 大星, 健治; 山岸, 則夫; Furuoka, Hidefumi; Sato, Motoyoshi; Ohoshi, Kenji; Yamagishi, Norio.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2139
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HSP70欠損牛の臨床学的・病理学的研究 OAK
古岡, 秀文; 佐藤, 基佳; 大星, 健治; 山岸, 則夫; Furuoka, Hidefumi; Sato, Motoyoshi; Ohoshi, Kenji; Yamagishi, Norio.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2138
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Inactivation of integrin-linked kinase induces aberrant tau phosphorylation via sustained activation of glycogen synthase kinase 3 beta in N1E-115 neuroblastoma cells OAK
Ishii, Toshiaki; Furuoka, Hidefumi; Muroi, Yoshikage; Nishimura, Masakazu; 石井, 利明; 古岡, 秀文; 室井, 喜景.
Integrin-linked kinase (ILK) is a focal adhesion serine/ threonine protein kinase with an important role in integrin and growth factor signaling pathways. Recently, we demonstrated that ILK is expressed in N1E-115 neuroblastoma cells and controls integrin-dependent neurite outgrowth in serum-starved cells grown on laminin (Ishii, T., Satoh, E., and Nishimura, M. ( 2001) J. Biol. Chem. 276, 42994 - 43003). Here we report that ILK controls tau phosphorylation via regulation of glycogen synthase kinase-3beta (GSK-3beta) activity in N1E-115 cells. Stable transfection of a kinase-deficient ILK mutant (DN-ILK) resulted in aberrant tau phosphorylation in N1E-115 cells at sites recognized by the Tau-1 antibody that are identical to some of the phosphorylation...
Palavras-chave: ALZHEIMERS-DISEASE NEURITE OUTGROWTH PROTEIN; NEURONS HYPERPHOSPHORYLATION KINASE-3-BETA ACCUMULATION BINDING ROLES.
Ano: 2003 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/747
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Pathology of naturally occurring porcine adenovirus type 4 infection in Japan OAK
Agungpriyono, Dewi Ratih; Nakagawa, Michio; Morozumi, Tetsuo; Yoshihara, Shinobu; Furuoka, Hidefumi; Matsui, Takane; アグリプリヨノ, デヴィ ラテイ; 中川, 迪夫; 両角, 徹雄; 吉原, 忍; 古岡, 秀文; 松井, 高峯.
Palavras-chave: Adenovirus; Encephalitis; Inclusion body; Nephritis; Swine.
Ano: 1997 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/1326
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Species-specificity of a Panel of Prion Protein Antibodies for the Immunohistochemical Study of Animal and Human Prion Diseases OAK
Furuoka, Hidefumi; Yabuzoe, Atushi; Horiuchi, Motohiro; Tagawa, Yuichi; Yokoyama, Takashi; Yamakawa, Yoshio; Shinagawa, Morikazu; Sata, Tetsutaro.
Monoclonal antibodies to the prion protein (PrP) have been of critical importance in the neuropathological characterization of PrP-related disease in men and animals. To determine the influence of species-specific amino-acid substitutions recognized by monoclonal antibodies, and to investigate the immunohistochemical reactivity of the latter, analyses were carried out on brain sections of cattle with bovine spongiform encephalopathy, sheep with scrapie, mice infected with scrapie, and human beings with Creutzfeldt-Jakob disease (CJD) or Gerstmann-Sträussler-Sheinker disease (GSS). Immunoreactivity varied between the antibodies, probably as the result of differences in the amino-acid sequence of the prion protein in the various species. Some monoclonal...
Palavras-chave: BSE; Cattle; CJD; GSS disease; Man; Mouse; Scrapie; Sheep.
Ano: 2007 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/1054
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The mesencephalic trigeminal sensory nucleus is involved in acquisition of active exploratory behavior induced by changing from a diet of exclusively milk formula to food pellets in mice OAK
Ishii, Toshiaki; Furuoka, Hidefumi; Kitamura, Nobuo; Muroi, Yoshikage; Nishimura, Masakazu; 古岡, 秀文; 北村, 延夫; 室井, 喜景; 石井, 利明.
Post-weaning mice fed exclusively milk display low-frequency exploratory behavior [Ishii, T., Itou, T., and Nishimura, M. (2005) Life Sci. 78, 174-179] compared to mice fed a food pellet diet. This low-frequency exploratory behavior switched to high-frequency exploration after a switch from exclusively milk formula to a food pellet diet. Acquisition of the high-frequency exploratory behavior was irreversible. Recently, we demonstrated that the mesencephalic trigeminal nucleus (Me5) is involved in the control of feeding and exploratory behavior in mice without modulating the emotional state [Ishii, T., Furuoka, H., Itou, T., Kitamura, N., and Nishimura, M. (2005) Brain Res. 1048, 80-86]. We therefore investigated whether the Me5 is involved in acquisition...
Palavras-chave: Exploratory behavior; Me5 lesions; Weaning.
Ano: 2006 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/739
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The mesencephalic trigeminal sensory nucleus is involved in the control of feeding and exploratory behavior in mice OAK
Ishii, Toshiaki; Furuoka, Hidefumi; Ito, Takuya; Kitamura, Nobuo; Nishimura, Masakazu.
The mesencephalic trigeminal nucleus (Me5), which receives input from oral proprioceptors and projects to higher brain regions, is involved in mastication-induced modulation of satiation. To investigate how the Me5 is involved in the control of feeding and exploratory behavior, we examined the effect of bilateral electrolytic lesions of the Me5 on feeding and exploratory behavior in mice. Mouse feeding and exploratory behaviors were analyzed using a food- search-compulsion-apparatus (FSCA), which was designed to distinguish between the two behaviors under standard living conditions. To assess anxiety in mice in an unfamiliar environment, exploratory activity was analyzed in an automated hole-board apparatus. Mice with bilateral Me5 lesions had unique...
Palavras-chave: Feeding; Exploratory behavior; Me5 lesions.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/740
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牛の遺伝性疾患の遺伝子診断のための基礎試料収集 OAK
古岡, 秀文; 大星, 健治; 山岸, 則夫; Furuoka, Hidefumi; Ohoshi, Kenji; Yamagishi, Norio.
Ano: 2005 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2137
Registros recuperados: 11
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