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Mimosine and cyclophosphamide: a potential new combination therapy used to prevent tumor development BABT
Dipe,Vânius Vinícius; Gotardo,André Tadeu; Haraguchi,Mitsue; Górniak,Silvana Lima.
The effects of mimosine (MI), which is an amino acid that is derived from Leucaena leucocephala, were evaluated on the growth of ascitic Ehrlich tumors, and the effects of the combination treatment of MI and cyclophosphamide (CY) on tumor growth were also assessed. Mice were divided into groups that received the following treatments over the course of 20 days: phosphate buffer solution (CO), MI, Ehrlich cells (E), E plus CY (EC), E plus MI (EM) and E plus MI and CY (EMC). No signs of toxicity were detected in the mice from the MI group. The mice from the EMC group showed reductions in body weights when compared with those from the E group. The animals from the EC, EM and EMC groups showed reductions in ascitic volume compared with those from the E group....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leucaena leucocephala; Mimosine; Ehrlich tumor; Cyclophosphamide; Anticancer activity.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132012000600010
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Rats offspring exposed to Ipomoea Carnea and handling during gestation: neurochemical evaluation BABT
Schwarz,Aline; Hosomi,Rosana Zoriki; Flório,Jorge Camilo; Bernardi,Maria Martha; Górniak,Silvana Lima; Spinosa,Helenice Souza.
The present study evaluated the central monoamine levels of male and female adult rat offspring exposed orally by gavage to 0.0, 0.7, 3.0 and 15.0 mg/kg I. carnea aqueous extract daily, from gestation day (GD) 5 to GD 21. Several alterations in the monoamine activity systems were observed. However, the major differences were noted between the 0.0 mg/kg and the no gavage control groups, showing that alterations showing that alterations were not due to the alterations to the aqueous extract. The control data showed that gavage and handling of dams were stressful enough to produce a significant decline in 3,4-dihydroxyphenylacetic acid (DOPAC) and an increase in vanilmandelic acid (VMA), indicating decreased dopamine (DA) and enhanced norepinephrine (NE)...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ipomoea carnea; Neurotransmitter; Perinate; Rats; Stress.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132007000300009
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