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Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis Inra
Disson, O.; Grayo, S.; Huillet, E.; Nikitas, G.; Langa-Vives, F.; Dussurget, O.; Ragon, M.; Le Monnier, A.; Babinet, C.; Cossart, P.; Lecuit, M..
The ability to cross host barriers is an essential virulence determinant of invasive microbial pathogens. Listeria monocytogenes is a model microorganism that crosses human intestinal and placental barriers, and causes severe maternofetal infections by an unknown mechanism(1). Several studies have helped to characterize the bacterial invasion proteins InlA and InlB(2). However, their respective species specificity has complicated investigations on their in vivo role(3,4). Here we describe two novel and complementary animal models for human listeriosis: the gerbil, a natural host for L. monocytogenes, and a knock-in mouse line ubiquitously expressing humanized E-cadherin. Using these two models, we uncover the essential and interdependent roles...
Tipo: Journal Article Palavras-chave: LISTERIA MONOCYTOGENES; BARRIERE PLACENTAIRE; PROTEINE BACTERIENNE; VIRULENCE; AGENT PATHOGENE; MODELISATION; MICROORGANISME; INFECTION; MALADIE HUMAINE; INTESTIN.
Ano: 2008 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009460b2e42&uri=/notices/prodinra1/2009/11/
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Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model Inra
Lecuit, M.; Sonnenburg, J. L.; Cossart, P.; Gordon, J. I..
Members of the genus Listeria provide a model for defining host responses to invasive foodborne enteropathogens. Active translocation of Listeria monocytogenes across the gut epithelial barrier is mediated by interaction of bacterial internalin (InlA) and its species-specific host receptor, E-cadherin, whereas translocation across Peyer’s patches through M-cells is InlA independent. To define microbial determinants and molecular correlates of the host response to translocation via these two routes, we colonized germ-free transgenic mice expressing the human enterocyte-associated E-cadherin receptor with wildtype (WT) or mutant L. monocytogenes strains, or its nonpathogenic noninvasive relative Listeria innocua, or with Bacteroides thetaiotaomicron, a...
Tipo: Journal Article Palavras-chave: LISTERIA MONOCYTOGENES; CADHERINE; BARRIERE INTESTINALE; LAMINA PROPRIA; PROTEINE BACTERIENNE; INTESTIN; MODELE ANIMAL; SOURIS; INFECTION; ENTEROPATHOGENE; MUTATION; EXPRESSION DES GENES; REPONSE IMMUNITAIRE; IMMUNITE.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200924d16b14&uri=/notices/prodinra1/2010/11/
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Human listeriosis and animal models Inra
Lecuit, M..
Human listeriosis is a potentially fatal foodborne infection caused by Listeria monocytogenes, an opportunistic psychrophile bacterium that is widespread in the environment. It has only recently emerged as a significant cause of human infection in industrialized countries, owing to appearance of a vulnerable population of immunocompromised individuals, and the concomitant development of large-scale agro-industrial plants and refrigerated food. Here we review the main clinical features of human listeriosis and highlight specificities and similarities with animal listeriosis in diverse species. Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis.
Tipo: Journal Article Palavras-chave: LISTERIOSE; BACTERIE PATHOGENE; MODELE ANIMAL; INFECTION; HOMME; MALADIE; IMMUNITE LISTERIOSIS; LISTERIA MONOCYTOGENES; ANIMAL MODEL .
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009e8130595&uri=/notices/prodinra1/2009/11/
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Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells Inra
Sousa, S.; Cabanes, D.; Bougnères, L.; Lecuit, M.; Sansonetti, P.; Tran-Van-Nhieu, G.; Cossart, P..
Listeria monocytogenes is a food-borne pathogen able to invade non-phagocytic cells. InlA, a L. monocytogenes surface protein, interacts with human E-cadherin to promote bacterial entry. L. monocytogenes internalization is a dynamic process involving co-ordinated actin cytoskeleton rearrangements and host cell membrane remodelling at the site of bacterial attachment. Interaction between E-cadherin and catenins is required to promote Listeria entry, and for the establishment of adherens junctions in epithelial cells. Although several molecular factors promoting E-cadherin-mediated Listeria internalization have been identified, the proteins regulating the transient actin polymerization required at the bacterial entry site are unknown. Here we...
Tipo: Journal Article Palavras-chave: PROTEINE MICROBIENNE; LISTERIA MONOCYTOGENES; BACTERIE PATHOGENE; CADHERINE; PENETRATION CELLULAIRE; SURFACE CELLULAIRE; HOMME; MODELISATION; MEMBRANE CELLULAIRE.
Ano: 2007 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD20092f54e3ca&uri=/notices/prodinra1/2009/09/
Registros recuperados: 4
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