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Exploring the mechanisms of graphene oxide behavioral and morphological changes in zebrafish. Repositório Alice
CLEMENTE, Z.; SILVA, G. H. da; NUNES, M. C. S.; MARTINEZ, D. S. T.; MAURER-MORELLI, C. V.; THOMAZ, A. A.; CASTRO, V. L. S. S. de.
Abstract: The presence of natural organic matter such as humic acid (HA) can influence the behavior of graphene oxide (GO) in the aquatic environment. In this study, zebrafish embryos were analyzed after 5 and 7 days of exposure to GO (100 mg L-1) and HA (20 mg L?1) alone or together. The results indicated that, regardless of the presence of HA, larvae exposed to GO for 5 days showed an increase in locomotor activity, reduction in the yolk sac size, and total length and inhibition of AChE activity, but there was no difference in enzyme expression. The statistical analysis indicated that the reductions in total larval length, yolk sac size, and AChE activity in larvae exposed to GO persisted in relation to the control group, but there was a recovery of...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Óxido de grafeno; Peixe de Água Doce; Matéria Orgânica; Composto Químico; Toxidez; Graphene oxide; Toxicity; Danio rerio; Ecotoxicology; Environmental impact; Aquatic environment; Humic acids; Biomarkers; Behavior change.
Ano: 2019 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1115452
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Exploring the mechanisms of graphene oxide toxicity to zebrafish embryo. Repositório Alice
CLEMENTE, Z.; SILVA, G. H. da; MARTINEZ, D. S. T.; MAURER-MORELLI, C. V.; NUNES, M. C. S.; THOMAZ, A. A.; CASTRO, V. L. S. S. de.
Many applications of graphene oxide (GO) are still in the research phase, but its promising uses have raised concerns about their risks to human health and the environment. Environmental factors, as the presence of humic substances in aquatic environment, can affect nanomaterials behavior and its toxicological effects. A previous study of our group revealed that the exposure of zebrafish embryos to GO is related to a reduction in total body length and in acetylcholinesterase activity. Thus, the aim of this study was to investigate the implications of GO exposure in muscular development and acetylcholinesterase expression. Zebrafish embryos (n=48/group) were exposed to GO (100 mg/L) in the presence or absence of humic acid (HA, 20 mg/L) during 5 days....
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Zebrafish.
Ano: 2017 URL: http://www.alice.cnptia.embrapa.br/alice/handle/doc/1078089
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Zebrafish exposure to graphene oxide is related to behavior changes. Repositório Alice
CLEMENTE, Z.; MARTINEZ, D. S. T.; OLIVEIRA, C. R. M.; MAURER-MORELLI, C. V.; NUNES, M. C. S.; CASTRO, V. L. S. S. de.
Graphene oxide (GO) has been explored to application in areas such as pharmaceutical and environmental sciences. However, GO safety is still unclear. Beyond that, environmental factors, as the presence of humic substances in aquatic environment, can affect nanomaterials behavior and its toxicological effects. The motor development of zebrafish embryo has been strongly characterized and established to neurotoxicity studies. A previous study of our group revealed that the exposure of zebrafish embryos to GO is related to a reduction in total body length and in acetylcholinesterase activity. Morphological and biochemical changes can be related to behavior abnormalities and affect organism?s survival, leading to serious environmental consequences. Thus, the...
Tipo: Resumo em anais de congresso (ALICE) Palavras-chave: Nanotoxicology; Embryotoxicity; Nanomaterials; Ecotoxicology.
Ano: 2016 URL: http://www.alice.cnptia.embrapa.br/handle/doc/1068076
Registros recuperados: 3
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