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Myosin Va is developmentally regulated and expressed in the human cerebellum from birth to old age BJMBR
Souza,C.C.R.; Dombroski,T.C.D.; Machado,H.R.; Oliveira,R.S.; Rocha,L.B.; Rodrigues,A.R.A.; Neder,L.; Chimelli,L.; Corrêa,V.M.A.; Larson,R.E.; Martins,A.R..
Myosin Va functions as a processive, actin-based motor molecule highly enriched in the nervous system, which transports and/or tethers organelles, vesicles, and mRNA and protein translation machinery. Mutation of myosin Va leads to Griscelli disease that is associated with severe neurological deficits and a short life span. Despite playing a critical role in development, the expression of myosin Va in the central nervous system throughout the human life span has not been reported. To address this issue, the cerebellar expression of myosin Va from newborns to elderly humans was studied by immunohistochemistry using an affinity-purified anti-myosin Va antibody. Myosin Va was expressed at all ages from the 10th postnatal day to the 98th year of life, in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Myosin Va; Human cerebellum; Postnatal development; Aging; Immunohistochemical expression.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000200164
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Relative frequency, clinical, neuroimaging, and postsurgical features of pediatric temporal lobe epilepsy BJMBR
Sales,L.V.; Velasco,T.R.; Funayama,S.; Ribeiro,L.T.; Andrade-Valença,L.P.; Neder,L.; Fernandes,R.M.F.; Araujo Jr.,D.; Machado,H.R.; Santos,A.C.; Leite,J.P..
We describe the relative frequency, clinical features, neuroimaging and pathological results, and outcome after pharmacological or surgical intervention for a series of pediatric patients with temporal lobe epilepsy (TLE) from an epilepsy center in Brazil. The medical records of children younger than 12 years with features strongly suggestive of TLE were reviewed from January 1999 to June 1999. Selected children were evaluated regarding clinical, EEG, and magnetic resonance imaging (MRI) investigation and divided into three groups according to MRI: group 1 (G1, N = 9), patients with hippocampal atrophy; group 2 (G2, N = 10), patients with normal MRI, and group 3 (G3, N = 12), patients with other specific temporal lesions. A review of 1732 records of...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Temporal lobe epilepsy; Children; Etiology; Prognosis; Developing countries.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001000013
Registros recuperados: 2
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