Sabiia Seb
PortuguêsEspañolEnglish
Embrapa
        Busca avançada

Botão Atualizar


Botão Atualizar

Ordenar por: RelevânciaAutorTítuloAnoImprime registros no formato resumido
Registros recuperados: 55
Primeira ... 123 ... Última
Imagem não selecionada

Imprime registro no formato completo
1-aryl-3-(4-(7-methylthieno[3,2-d]pyrimidin-4-yloxy)phenyl)ureas: synthesis and molecular modelling studies using VEGFR-2 IPB - Escola Superior Agrária
Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria João R.P..
The development of anticancer drugs inhibiting angiogenesis has been an area of extensive research in the past decade. Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of VEGFR-2 tyrosine kinase activity could potentially inhibit angiogenesis and tumor growth. Recently works describing thienopyrimidine2 and thienopyrimidine 1,3-diarylureas3 as VEGFR-2 inhibitors have emerged in the literature. Here we present the synthesis of new...
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6079
Imagem não selecionada

Imprime registro no formato completo
1-Aryl-3-[4-(thieno[3,2-d]pyrimidin-4-yloxy)phenyl]ureas as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies IPB - Escola Superior Agrária
Soares, Pedro; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Borges, Fernanda; Queiroz, Maria João R.P..
Angiogenesis is a requirement for tumor growth and metastasis and occurs through several signalling pathways. One key pathway that initiates proliferation and migration of endothelial cells is signalling through the vascular endothelial growth factor receptor-2 (VEGFR-2).1 Therefore, small molecules that block this signalling pathway through inhibition of the VEGFR tyrosine kinase activity could potentially inhibit angiogenesis and tumour growth. Recently works describing thienopyrimidines2 and thienopyridine ureas3 as inhibitors of VEGFR-2 have appeared in the literature. Here we present the synthesis of new 1,3-diarylureas 2 starting by regioselective nucleophilic substitution of the 4-chlorothieno[3,2-d]pyrimidine with 4-aminophenol to obtain...
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6077
Imagem não selecionada

Imprime registro no formato completo
A convenient high performance computing (HPC) methodology for virtual screening using Autodock 4 IPB - Escola Superior Agrária
Abreu, Rui M.V.; Froufe, Hugo J.C.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P..
Tipo: ConferenceObject
Ano: 2008 URL: http://hdl.handle.net/10198/3551
Imagem não selecionada

Imprime registro no formato completo
Antifungal activity of diarylamines in the benzo[b]thiophene series and SAR IPB - Escola Superior Agrária
Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Barbosa, Sandra; Estevinho, Leticia M.; Queiroz, Maria João R.P..
Several diarylamines la-f and 2 were prepared using palladium-catalyzed C-N coupling of electron deficient or rich benzo[b]thienylbromides with aromatic amines. Using 2-aminopyridine a one pot C-N coupling and intermolecular cyclization involving the nitrogen of the pyridine, with lost of ethanol, occurred giving compound 3.
Tipo: ConferenceObject
Ano: 2004 URL: http://hdl.handle.net/10198/3729
Imagem não selecionada

Imprime registro no formato completo
Antioxidant properties of diarylamines derivatives of benzo[b]thiophenes and amino acids IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.; Barros, Lillian; Abreu, Ana S.; Ferreira, Paula M.T..
Free radical formation is associated with the normal natural metabolism of aerobic cells. The oxygen consumption inherent to cell growth leads to the generation of a series of oxygen free radicals. The interaction of these species with lipid molecules produces new radicals that may interact with biological systems in a cytotoxic manner. Free radicals and their uncontrolled production are responsible for several pathological processes, such as certain tumours (prostate and colon cancers) the reducing properties of diarylamines make them very important as antioxidants, especially as radical scavengers.
Tipo: ConferenceObject
Ano: 2007 URL: http://hdl.handle.net/10198/3720
Imagem não selecionada

Imprime registro no formato completo
Anti-proliferative activity of thieno[3,2-b]pyridine derivatives in tumoral and primary hepatic cell lines. IPB - Escola Superior Agrária
Abreu, Rui M.V.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R.; Adega, Filomena; Chaves, Raquel.
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3367
Imagem não selecionada

Imprime registro no formato completo
Biodegradation of bioaccessible textile azo dyes By Phanerochaete chrysosporium IPB - Escola Superior Agrária
Martins, Maria Adosinda; Ferreira, Isabel C.F.R.; Santos, Isabel; Queiroz, Maria João R.P.; Lima, Nelson.
Tipo: ConferenceObject
Ano: 2009 URL: http://hdl.handle.net/10198/3734
Imagem não selecionada

Imprime registro no formato completo
Biodegradation of textile Azo Dyes by Phanerochaete chrysosporium IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Santos, Isabel M.; Queiroz, Maria João R.P.; Lima, Nelson.
Azo dyes are used extensively in the textile and dyestuff industries and effluents from these industrial processes are usually resistant to biological treatment. Textile azo dyes with bioaccessible groups such as guaiacol and 2,6-dimethoxyphenol, for lignin-degrading fungus as P. chrysosporium were synthesised.
Tipo: ConferenceObject
Ano: 1998 URL: http://hdl.handle.net/10198/3726
Imagem não selecionada

Imprime registro no formato completo
Chemical, biochemical and electrochemical assays to evaluate antioxidant properties of three new diarylamines in the thieno[3,2-b]pyridine series. IPB - Escola Superior Agrária
Calhelha, Ricardo C.; Abreu, Rui M.V.; Vilas-Boas, Miguel; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R..
The continuous discovery of new synthetic products with antioxidant activity is of primary importance as they may substitute with advantage the currently used antioxidant compounds. The reducing properties of diarylamines make them very important as antioxidants, especially as radical scavengers as it has been demonstrated by our and other research groups.1-3 Three di(hetero)arylamines were prepared by C–N coupling of the methyl 3-amino-6-bromothieno[3,2-b]pyridine-2-carboxylate with bromonitrobenzenes and further reduced to the amino compounds 1a-c.4
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6087
Imagem não selecionada

Imprime registro no formato completo
ChemT, a software for building template-based 3D chemical libraries. IPB - Escola Superior Agrária
Abreu, Rui M.V.; Froufe, Hugo J.C.; Daniel, Pedro O.M.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R..
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3329
Imagem não selecionada

Imprime registro no formato completo
ChemT, an open-source software for building template-based chemical libraries IPB - Escola Superior Agrária
Abreu, Rui M.V.; Froufe, Hugo J.C.; Daniel, Pedro O.M.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R..
Mushrooms represent an unlimited source of compounds with antitumor and immunostimulating properties and mushroom intake as been shown to reduce the risk of breast cancer. A large number of LMW (low molecular weight) compounds present in mushrooms have been identified including: phenolic acids, flavonoids, tocopherols, carotenoids, sugars and fatty acids. In order to evaluate which wild mushroom LMW compounds may be involved in anti-breast cancer activity we selected a representative dataset of 43 LMW compounds and performed molecular docking against 3 known protein targets involved in breast cancer (Aromatase, Estrone Sulfatase and 17β-HSD-1) using AutoDock4 as docking software. The estimated inhibition constants for all LMW compounds were determined and...
Tipo: Article Palavras-chave: Mushrooms; Nutraceuticals; Breast cancer; Molecular Docking; AutoDock4.
Ano: 2011 URL: http://hdl.handle.net/10198/6231
Imagem não selecionada

Imprime registro no formato completo
Desenvolvimento de ferramentas de bioinformática para aplicação em Química Medicinal: MOLA e ChemT. IPB - Escola Superior Agrária
Abreu, Rui M.V.; Froufe, Hugo J.C.; Queiroz, Maria João R.P.; Ferreira, Isabel C.F.R..
O desenvolvimento de novas ferramentas computacionais é uma parte integral da área da bioinformática. A disponibilização destas ferramentas em modalidade de acesso livre permitir o acesso a um maior número de utilizadores e facilita significativamente o seu desenvolvimento pela facilidade de troca de ideias entre utilizadores. Neste trabalho, serão apresentados dois softwares desenvolvidos pelo nosso grupo de investigação: 1) MOLA1 que automatiza o screening virtual de bibliotecas de compostos com baixa massa molar, utilizando as ferramentas de docking AutoDock4 e AutoDock Vina; 2) ChemT2 que permite a geração de bibliotecas de compostos análogos de baixa massa molar, tendo como base uma estrutura química de interesse. Será ainda apresentado um exemplo de...
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6072
Imagem não selecionada

Imprime registro no formato completo
Electrochemical evaluation of the redox-properties of diarylamines in the 2,3-dimethylbenzo[b]thiophene series IPB - Escola Superior Agrária
Falcão, Soraia; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vilas-Boas, Miguel; Queiroz, Maria João R.P..
Tipo: ConferenceObject
Ano: 2008 URL: http://hdl.handle.net/10198/3531
Imagem não selecionada

Imprime registro no formato completo
Electrochemical study of diarylamines in the benzo[b]thiophene series IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Vilas-Boas, Miguel; Falcão, Soraia; Queiroz, Maria João R.P..
The search for new molecules with antioxidant properties is a very active domain of research , since they can protect the human body from free radicals and retard the progress of many chronic diseases, such a. vascular diseases, some forms of cancer and oxidative stress responsible for D NA, protein and membrane damage.
Tipo: ConferenceObject
Ano: 2007 URL: http://hdl.handle.net/10198/3710
Imagem não selecionada

Imprime registro no formato completo
Estudos de biodegradabilidade de corantes azo de aplicação têxtil por Phanerochaete chrysosporium IPB - Escola Superior Agrária
Martins, M.A.; Ferreira, Isabel C.F.R.; Santos, I.M.; Queiroz, Maria João R.P.; Lima, Nelson.
Sintetizaram-se corantes azo de aplicação têxtil, usando como componentes diazo ácidos aminobenzóicos e arrunossulfónicos e como componentes de acoplamento 2.metoxifenol e 2,6-dimetoxifenoL A utilização destas componentes de acoplamento !tve como objectivo aumentar a bioacessibilidade dos corantes ao fungo lenhinolítico da podridão branca Phanerochaete chrysosporium, já que estes grupos estão presentes na estrutura da lenhina e têm sido referidos como pontos de acesso para o sistema enzimático lenhinolítico do fungo. As experiências de biodegradação realizaram-se em meio líquido. com sacarose e em condições limitantes de azoto, com agitação e !tmperatura controladas. A biodegradação dos corantes foi acompanhada por espec trofotometria UV-Visível,...
Tipo: ConferenceObject
Ano: 1999 URL: http://hdl.handle.net/10198/3875
Imagem não selecionada

Imprime registro no formato completo
Evaluation of the antioxidant properties of diarylamines in the benzo[b]thiophene series by free radical scavenging activity and reducing power IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.; Vilas-Boas, Miguel; Estevinho, Leticia M.; Begouin, Agathe; Kirsch, Gilbert.
The antioxidant properties of substituted diarylamines in the benzo[b]thiophene series were evaluated by their reducing power and free radical scavenging activity. The results were compared with those of standards: acid ascorbic for the first method and BHA and BHT for the second. For both methods it was possible to establish some structure–activity relationships (SARs) based on the position of the arylamination on the benzo[b]thiophene moiety, the presence of different substituents on the phenyl ring (F, 1 or 2 OMe) and on the thiophene ring (H, CO2Et, CO2H).
Tipo: Article Palavras-chave: Diarylamines; Benzothiophenes; Antioxidant activity; Structure–activity relationships.
Ano: 2006 URL: http://hdl.handle.net/10198/825
Imagem não selecionada

Imprime registro no formato completo
High efficient intramolecular cyclisation of ortho-halodiarylamides or amines to tienocarbazoles and indolobenzo[b]thiophenes IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.; Kirsch, Gilbert.
Tipo: ConferenceObject
Ano: 2002 URL: http://hdl.handle.net/10198/3498
Imagem não selecionada

Imprime registro no formato completo
Insights in the antioxidant activity of diarylamines from the 2,3-dimethylbenzo[b]thiophene by the redox profile IPB - Escola Superior Agrária
Abreu, Rui M.V.; Falcão, Soraia; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P.; Vilas-Boas, Miguel.
Cyclic voltammetry was used to evaluate the antioxidant activity of 7-aryl or 7-heteroarylamino-2,3-dimethylbenzo[b]thiophenes previously synthesized by some of us, comparing their oxidation potentials with those of the well-known synthetic standards (BHA, BHT). Compounds with electron-donating groups on the arylamine moiety have lower Ep/2 than compounds with electron-withdrawing groups or electron-deficient rings (pyridines). The position of the methoxy group on the arylamine moiety also changes the oxidation potential: lower Ep/2 for the diarylamines with methoxy groups in the para position. Comparing the first peak potential with the ones of BHA and BHT, the diarylamine compounds show lower oxidation potential, and therefore higher reducing power. A...
Tipo: Article Palavras-chave: Benzo[b]thiophene; Diarylamines; Antioxidant properties; Electrochemical assays.
Ano: 2009 URL: http://hdl.handle.net/10198/2717
Imagem não selecionada

Imprime registro no formato completo
Lipid peroxidation inhibition, free radical scavenging activity and electrochemical behaviour of a dihydroxylated di(hetero)arylamine IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Barros, Lillian; Falcão, Soraia; Vilas-Boas, Miguel; Queiroz, Maria João R.P..
The skin provides the first line of defense against oxidative damage induced by environmental factors, having an elaborated antioxidant system designed to deal with free radicals and oxidative stress. However, under severe stress conditions this biological response is not sufficient, leading to oxidative damage and, in consequence, to skin disorders, immunosuppresion, premature skin aging and ultimately cancer.
Tipo: ConferenceObject
Ano: 2007 URL: http://hdl.handle.net/10198/3715
Imagem não selecionada

Imprime registro no formato completo
Methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates as potential inhibitors of VEGFR-2: synthesis and molecular modelling studies. IPB - Escola Superior Agrária
Peixoto, Daniela; Calhelha, Ricardo C.; Dias, Sofia; Froufe, Hugo J.C.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Queiroz, Maria João R.P..
When over expressed or mutated, protein tyrosine kinases become potent oncoproteins that cause deregulated cell growth angiogenesis and metastasis. Because of these characteristics, they are targets for small molecule inhibitors in the treatment of cancer. Recently some thieno[3,2-c]pyridine 1,3-diarylurea derivatives were prepared as VEGFR-2 (vascular endothelium growth factor receptor-2) inhibitors.1 Here we present the synthesis of methyl 3-[4-(3-arylureido)phenylamino]thieno[3,2-b]pyridine-2-carboxylates 2 in excellent yields, by reaction of the methyl 3-(4-aminophenylamino)thieno[3,2-b]pyridine-2-carboxylate 1, prepared also by us, with different arylisocyanates (Scheme).
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6006
Registros recuperados: 55
Primeira ... 123 ... Última
 

Empresa Brasileira de Pesquisa Agropecuária - Embrapa
Todos os direitos reservados, conforme Lei n° 9.610
Política de Privacidade
Área restrita

Embrapa
Parque Estação Biológica - PqEB s/n°
Brasília, DF - Brasil - CEP 70770-901
Fone: (61) 3448-4433 - Fax: (61) 3448-4890 / 3448-4891 SAC: https://www.embrapa.br/fale-conosco

Valid HTML 4.01 Transitional