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Beta-N-Methylamino-L-Alanine: LC-MS/MS Optimization, Screening of Cyanobacterial Strains and Occurrence in Shellfish from Thau, a French Mediterranean Lagoon ArchiMer
Reveillon, Damien; Abadie, Eric; Sechet, Veronique; Brient, Luc; Savar, Veronique; Bardouil, Michele; Hess, Philipp; Amzil, Zouher.
beta-N-methylamino-L-alanine (BMAA) is a neurotoxic non-protein amino acid suggested to be involved in neurodegenerative diseases. It was reported to be produced by cyanobacteria, but also found in edible aquatic organisms, thus raising concern of a widespread human exposure. However, the chemical analysis of BMAA and its isomers are controversial, mainly due to the lack of selectivity of the analytical methods. Using factorial design, we have optimized the chromatographic separation of underivatized analogues by a hydrophilic interaction chromatography coupled to tandem mass spectrometry (HILIC-MS/MS) method. A combination of an effective solid phase extraction (SPE) clean-up, appropriate chromatographic resolution and the use of specific mass spectral...
Tipo: Text Palavras-chave: Cyanotoxins; BMAA; DAB; AEG; HILIC-MS/MS; Cyanobacteria; Bivalve mollusks; French Mediterranean.
Ano: 2014 URL: http://archimer.ifremer.fr/doc/00245/35579/34112.pdf
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BMAA et cyanotoxines : microalgues productrices et niveaux d’accumulation dans les organismes marins ArchiMer
Reveillon, Damien.
BMAA (â-N-methylamino-L-alanine) is a non proteinogenic neurotoxic amino acid that has been associated with amyotrophic lateral sclerosis. Its analytical detection is widely debated thus the global production of BMAA by cyanobacteria is questioned. We first aimed at developing an analytical method allowing for highly selective identification of BMAA and isomers, using HILIC chromatography coupled to mass spectrometry. Then, we have cultivated and analyzed more than 50 microalgae (e.g. cyanobacteria, diatoms). Unlike DAB, one of its natural isomer, BMAA was only reported in five diatom species and cannot be accounted as a cyanotoxin anymore. In parallel, we have evaluated the presence of BMAA on the three French coasts. The presence of BMAA in different...
Tipo: Text Palavras-chave: DAB; Cyanotoxines; CL-SM/SM; Diatomées; Cyanobactéries; Bivalves; BMAA; DAB; Cyanotoxins; LC-MS/MS; Diatoms; Cyanobacteria; Bivalves.
Ano: 2015 URL: http://archimer.ifremer.fr/doc/00295/40651/39617.pdf
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Systematic detection of BMAA (β-N-methylamino-L-alanine) and DAB (2,4-diaminobutyric acid) in mollusks collected in shellfish production areas along the French coasts ArchiMer
Reveillon, Damien; Sechet, Veronique; Hess, Philipp; Amzil, Zouher.
The neurotoxin β-N-methylamino-L-alanine (BMAA) is naturally present in some microalgal species in the marine environment. The accumulation of BMAA has widely been observed in filter-feeding bivalves that are known to consume primary producers constituting the base of complex aquatic food webs. This study was performed to assess the occurrence of BMAA and isomers in mollusks collected from nine representative shellfish production areas located on the three French coasts (Channel, Atlantic and Mediterranean sites). The use of a highly selective and sensitive HILIC-MS/MS method, with D5DAB as internal standard, revealed the systematic detection of BMAA and DAB, in concentrations ranging from 0.20 to 6.7 μg g-1 dry weight of digestive gland tissues of...
Tipo: Text Palavras-chave: BMAA; Chaetoceros; Thalassiosira; Phaeodactylum; Bivalves; Seafood.
Ano: 2016 URL: http://archimer.ifremer.fr/doc/00297/40780/39784.pdf
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β-N-methylamino-l-alanine (BMAA) and isomers: Distribution in different food web compartments of Thau lagoon, French Mediterranean Sea ArchiMer
Reveillon, Damien; Abadie, Eric; Sechet, Veronique; Masseret, Estelle; Hess, Philipp; Amzil, Zouher.
The neurotoxin BMAA (β-N-methylamino-l-alanine) and its isomer DAB (2,4-diaminobutyric acid) have been detected in seafood worldwide, including in Thau lagoon (French Mediterranean Sea). A cluster of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease associated with BMAA, has also been observed in this region. Mussels, periphyton (i.e. biofilms attached to mussels) and plankton were sampled between July 2013 and October 2014, and analyzed using HILIC-MS/MS. BMAA, DAB and AEG (N-(2-aminoethyl)glycine) were found in almost all the samples of the lagoon. BMAA and DAB were present at 0.58 and 0.83, 2.6 and 3.3, 4.0 and 7.2 μg g−1 dry weight in plankton collected with nets, periphyton and mussels, respectively. Synechococcus sp., Ostreococcus...
Tipo: Text Palavras-chave: BMAA; Diatoms; Chaetoceros sp.; Seston; Mytilus galloprovincialis; HILIC-MS/MS.
Ano: 2015 URL: http://archimer.ifremer.fr/doc/00275/38607/37192.pdf
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