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2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main...
Tipo: Article Palavras-chave: 2; 3-Diarylxanthones Reactive oxygen species Reactive nitrogen species Scavenging activity Antioxidant activity.
Ano: 2010 URL: http://hdl.handle.net/10198/3241
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NDPO2 as a selective generator of 1o2 used in the scavenging activity assay of 2,3-diarylxanthones IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3495
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ROS and RNS Scavenging Activity by 2,3-Diarylxanthones IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Xanthones constitute an important class of heterocyclic compounds that commonly occur in nature. The inclusion of aryl groups has only been reported for a few synthetic derivatives, being the 2,3-diaryl moiety recently introduced by our group.~ The pharmacological properties of both natural and synthetic xanthones have attracted great attention namely as antioxidant, anti-allergic, anti-inflammatory, antimalarial and antitumour protectors. The antioxidant activity deserves special mention, considering the potent scavenging activity for reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating activity already reported for some compounds bearing the xanthone scaffold. Thus, the main goal of this work was to evaluate the...
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3797
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