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Altered Levels of Nodal Excitability by Rate-Dependent Inhibitory Effects of Essential Oil of Citrus aurantium on the Electrophysiological Properties of Isolated Perfused Rabbit AV-Node: Protective Role in the Prevention of Ouabain Toxicity International Journal of Morphology
Khori,Vahid; Nayebpour,Mohsen; Mansourian,Azad Reza; Davarian,Ali; Naseri,Mohsen; Salehi,Aref; Alizadeh,Ali-Mohamad.
Treatment of supraventricular arrhythmia includes a wide range of medical interventions. Herbal remedies are suitable alternatives to synthetic drugs due to their availability, minimal side effects and lower price. Pharmacological studies and traditional medical literature point to the cardiovascular effects of Citrus aurantium L. (Rutaceae) in many instances. In the present study we used isolated perfused AV-node of rabbit as an experimental model to determine the effect of various concentrations of essential oil of C. aurantium (0.1-0.3 v/v) on the nodal conduction time and refractoriness of an isolated rabbit AV-nodal preparations. Selective stimulation protocols were used to independently quantify AV nodal recovery, facilitation and fatigue in 18...
Tipo: Journal article Palavras-chave: Citrus aurantium; Isolated AV-node; Arrhythmia; Herbal drugs.
Ano: 2010 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200019
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