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Registros recuperados: 13
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A study of the antitumour potential of three Portuguese wild mushrooms IPB - Escola Superior Agrária
Vaz, Josiana A.; Ferreira, Diana F.; Almeida, Gabriela M.; Cardoso, Adélia; Almeida, Ana P.; Martins, Anabela; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena.
Natural matrixes such as mushrooms represent a rich source of biologically active compounds with recognized potential in drug discovery and development [1,2]. Indeed, many pre-clinical studies have been conducted in human tumour cell lines and in some cases, a number of compounds extracted from mushrooms have entered clinical trials [3]. Our previous results showed that extracts from Agaricus arvensis, Suillus collinitus and Clytocibe alexandri are promising sources of low molecular weight bioactive compounds [4]. The aim of the present work was to study the antitumour potential of the extracts and isolated compounds from three Portuguese wild mushrooms by verifying their effect on various human tumour cell lines in what concerns effect on cell growth,...
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6002
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Antioxidant activity and growth inhibitory activity of Portuguese wild mushrooms IPB - Escola Superior Agrária
Vaz, Josiana A.; Heleno, Sandrina A.; Martins, Anabela; Almeida, Gabriela M.; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3332
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Bioactive properties of Clitocybe alexandri IPB - Escola Superior Agrária
Vaz, Josiana A.; Heleno, Sandrina A.; Martins, Anabela; Almeida, Gabriela M.; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Some mushrooms may have antioxidant and tumour cell growth inhibitory activities. However, there is no data on Portuguese wild mushrooms. The aim of this work was lo study extracts obtained from the Portuguese wild mushroom Clitocybe alexandri, regard the in vitro antioxidant acclivity and the growth inhibitory activity in human tumour cell lines.
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3696
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Bioactive properties of Lepista inversa IPB - Escola Superior Agrária
Vaz, Josiana A.; Heleno, Sandrina A.; Martins, Anabela; Almeida, Gabriela M.; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3334
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Bioactivity and chemical characterization of Fistulina hepatica extracts. IPB - Escola Superior Agrária
Vaz, Josiana A.; Tavares, Catarina; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Fistulina hepatica, the beefsteak fungus, belongs to the order Agaricales and is commonly found all over Europe, North America, Australia and North Africa. Being a good edible species, it has also been investigated for its medicinal and pharmaceutical capacities. The anti-tumor activity of F. hepatica polysaccharides extracts from the mycelial culture was reported after intraperitoneally administration into white mice [1]. Nevertheless, nothing has been reported in phenolic and polysaccharidic extracts from the fruiting body.
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6204
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Chemical composition of wild edible mushrooms and antioxidant properties of their water soluble polysaccharidic and ethanolic fractions IPB - Escola Superior Agrária
Vaz, Josiana A.; Barros, Lillian; Martins, Anabela; Santos-Buelga, Celestino; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Mushrooms have become attractive as functional foods and as a source of physiologically beneficial bioactive compounds. Herein, we describe and compare the chemical constituents (phenolic compounds, macronutrients, sugars, fatty acids, tocopherols and ascorbic acid) of four wild edible mushrooms widely appreciated in gastronomy: Armillaria mellea (Vahl) P. Kumm, Calocybe gambosa (Fr.) Donk, Clitocybe odora (Fr.) P. Kumm., Coprinus comatus (O.F. Müll.) Pers. Furthermore, the antioxidant activity of their water soluble polysaccharidic and ethanolic fractions was studied by three different in vitro assays. Coprinus comatus revealed the highest concentrations of sugars (43.23 g/100 g dry weight), PUFA (77.46%), phenolic compounds (45.02 mg/Kg), tocopherols...
Tipo: Article Palavras-chave: Wild edible mushrooms; Bioactive compounds; Phenolic compounds; Polysaccharides; Chemical composition.
Ano: 2011 URL: http://hdl.handle.net/10198/3881
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Clitocybe alexandri extract induces apoptosis in a lung cancer cell line: identification of phenolic acids with cytotoxic potential. IPB - Escola Superior Agrária
Vaz, Josiana A.; Almeida, Gabriela M.; Ferreira, Diana; Ferreira, Isabel C.F.R.; Martins, Anabela; Vasconcelos, M. Helena.
Natural products which grow in adverse conditions, such as fungi, are a possible rich source of biologically active compounds with potential for drug discovery [1,2]. We have recently reported the growth inhibitory activity of extracts from Clitocybe alexandri, a wild mushroom collected from the northwest of Portugal, in human tumour cell lines (NCI-H460, MCF-7, HCT-15 and AGS) [3]. The ethanolic extract was the most potent one, particularly in NCI-H460 cells (GI50 24.8 ± 2.3 μg/ml) [3]. The aim of this work was to further study the potential of this extract as a possible source of cytotoxic compounds. In order to understand the mechanism of action of this extract in the NCI-H460 cells, the effects on cell cycle (following PI labelling) and apoptosis...
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6036
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Comparative study between phenolic and polysaccharidic extracts of Suillus collinitus: chemical characterization and growth inhibitory activity in human tumour cell lines. IPB - Escola Superior Agrária
Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an important source of compounds with potential antitumor and immunostimulating properties, including low-molecular-weight (LMW, e.g. phenolic compounds) and high-molecular-weight (HMW, e.g polysaccharides) compounds. Furthermore, they may have potential as functional foods and sources of novel molecules. The Northeast of Portugal is one of the European regions with higher mushrooms biodiversity.
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6076
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Compounds from wild mushrooms with antitumor potential IPB - Escola Superior Agrária
Ferreira, Isabel C.F.R.; Vaz, Josiana A.; Vasconcelos, M. Helena; Martins, Anabela.
For thousands of years medicine and natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial health effects without known negative side-effects and can be moderately used on a regular basis without harm. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds which are modulators of tumour cell growth. Furthermore, they may have potential as functional foods and sources of novel molecules....
Tipo: Article Palavras-chave: Mushrooms; Antitumor; Low-molecular-weight compounds; High-molecular-weight compounds.
Ano: 2010 URL: http://hdl.handle.net/10198/2646
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In vitro growth inhibitory activity of the Portuguese wild mushroom Clitocybe alexandri in human tumour cell lines. IPB - Escola Superior Agrária
Vaz, Josiana A.; Almeida, Gabriela M.; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
Tipo: ConferenceObject
Ano: 2010 URL: http://hdl.handle.net/10198/3366
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Phenolic profile in edible and non edible wild mushrooms from Northeast Portugal. IPB - Escola Superior Agrária
Vaz, Josiana A.; Barros, Lillian; Martins, Anabela; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
The implication of oxidative and nitrosative stress in the etiology and progression of several acute and chronic clinical disorders such as cancer, cardiovascular and neurodegenerative diseases, has led to the suggestion that natural antioxidants may have health benefits as prophylactic agents. Against this background, the possibility of including mushrooms, which contain significant amounts of bioactive phytochemicals, in our diets may provide desirable health benefits, beyond that of basic nutrition. Phenolic compounds might provide health benefits associated with reduced risk of chronic diseases which may relate to their ability to reduce agents by donating hydrogen and quenching singlet oxygen. It is our interest to characterize the phenolic...
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6085
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Synthesis of aminodiarylamines in the thieno[3,2-b]pyridine series and effects on tumor cell growth inhibition, cell cycle and apoptosis IPB - Escola Superior Agrária
Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Abreu, Rui M.V.; Vale-Silva, Luís A.; Pinto, Eugénia; Lima, Raquel T.; Alvelos, M. Inês; Vasconcelos, M. Helena; Queiroz, Maria João R.P..
Several series of compounds that include the thienopyridine scaffold have been reported as inhibitors of known cancer therapeutic targets or as inhibitors of cell proliferation in tumor cell lines [1,2]. Our research group has already synthesized several thieno[3,2-b]pyridine derivatives by Pd-catalyzed C-C (Suzuki and Sonogashira) and C-N (Buchwald-Hartwig) couplings and some of them have presented tumor cell growth inhibitory activity in cell lines [3- 5].
Tipo: ConferenceObject
Ano: 2011 URL: http://hdl.handle.net/10198/6241
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Wild mushrooms Clitocybe alexandri and Lepista inversa: In vitro antioxidant activity and growth inhibition of human tumour cell lines IPB - Escola Superior Agrária
Vaz, Josiana A.; Heleno, Sandrina A.; Martins, Anabela; Almeida, Gabriela M.; Vasconcelos, M. Helena; Ferreira, Isabel C.F.R..
The in vitro antioxidant and growth inhibitory activity of extracts obtained from two Portuguese wild mushrooms (Clitocybe alexandri and Lepista inversa) was studied in human tumour cell lines. The extracts were phenolic (methanolic and ethanolic) and polysaccharidic (boiling water). The antioxidant activity assays included evaluation of radical-scavenging capacity, reducing power and inhibition of lipid peroxidation measured in liposome solutions. Extract-induced cell growth inhibition was measured in four different tumour cell lines (lung, breast, colon and gastric cancer) using the SRB assay. The polysaccharidic extract oft. inversa was the most potent as antioxidant (EC50 < 1.8 +/- 0.1 mg/ml), while the phenolic ethanolic extract of C alexandri was...
Tipo: Article Palavras-chave: Wild mushrooms; Antioxidant activity; Growth inhibitory activity.
Ano: 2010 URL: http://hdl.handle.net/10198/3037
Registros recuperados: 13
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