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2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen species: A structure–activity relationship study IPB - Escola Superior Agrária
Santos, Clementina M.M.; Freitas, Marisa; Ribeiro, Daniela; Gomes, Ana; Silva, Artur; Cavaleiro, José; Fernandes, Eduarda.
Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a broad spectrum of biological activities, many of them related to their antioxidant ability, including the scavenging of reactive oxygen species (ROS) and reactive nitrogen species (RNS), as well as metal chelating effects. Considering the interesting and promising antioxidant activities present in compounds derived from the xanthone core, the main...
Tipo: Article Palavras-chave: 2; 3-Diarylxanthones Reactive oxygen species Reactive nitrogen species Scavenging activity Antioxidant activity.
Ano: 2010 URL: http://hdl.handle.net/10198/3241
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