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Single-chain variable fragments antibody specific toCorynespora cassiicola toxin, cassiicolin, reduces necrotic lesion formation in Hevea brasiliensis Inra
Sunderasan, E.; Kadir, R.A.; Pujade-Renaud, V.; de Lamotte, F.; Yeang, H.Y.; Nathan, S..
Corynespora leaf disease poses a serious threat to rubber cultivation because infected leaves develop necrotic lesions and abscise, leaving the tree unproductive. The destructiveness of Corynespora cassiicola has been largely attributed to cassiicolin, a protein toxin secreted by the fungus. Recombinant antibody technology offers hope to curtail the disease whereby single-chain variable fragments (scFv) specific to cassiicolin could bind and deactivate the toxin in genetically modified rubber trees that harbour the antibody gene. A scFv phage library was constructed from heavy and light variable chains of IgG from cassiicolin immunized Balb/C mice spleen. Biopanning of the phage library yielded a scFv clone with high specificity to cassiicolin. The...
Tipo: Journal Article Palavras-chave: CLONE; OLIGONUCLEOTIDE CORYNESPORA CASSIICOLA; CASSIICOLIN; ANTI-CASSIICOLIN SCFV; DETACHED HEVEA LEAF BIOASSAY.
Ano: 2009 URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD2009c497e060&uri=/notices/prodinra1/2010/03/
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