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| Baron-Menguy, C.; Bocquet, A.; Guihot, A.L.; Chappard, D.; Amiot, M.J.; Andriantsitohaina, R.; Loufrani, L.; Henrion, D.. |
| Polyphenols, present in green tea, grapes, or red wine, have paradoxical properties: they protect against cardiac and cerebral ischemia but inhibit angiogenesis in vitro. So we investigated the effects of polyphenols in vivo on postischemic neovascularization. Rats treated with low (0.2 mg · kg-1 · day-1) or high (20 mg · kg-1 · day-1) doses of red wine polyphenolic compounds (RWPC) were submitted to femoral artery ligature on the left leg. Two wks after ligature, high doses of RWPC (i.e., 7 glasses of red wine) reduced arterial, arteriolar, and capillary densities and blood flow in association with an inhibition of a PI3 kinase-Akt-endothelial NO synthase (eNOS) pathway, decreased VEGF expression, and lower metalloproteinase (MMP) activation. Low doses of... |
| Tipo: Journal Article |
Palavras-chave: VIN ROUGE; CIRCULATION SANGUINE; VAISSEAU SANGUIN; ANGIOGENESE VEGF; REMODELING; NEOVASCULARIZATION; NITRIC OXIDE; BLOOD FLOW. |
| Ano: 2007 |
URL: http://www.prodinra.inra.fr/prodinra/pinra/doc.xsp?id=PROD200717f0c19c&uri=/notices/prodinra1/2007/12/ |
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