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Antiproliferative and cytotoxic effects of purple pitanga (Eugenia uniflora L.) extract on activated hepatic stellate cells. Repositório Alice
DENARDIN, C. C.; PARISI, M. M.; MARTINS, L. A. M.; TERRA, S. R.; BOROJEVIC, R.; VIZZOTTO, M.; PERRY, M. L.; EMANUELLI, T.; GUMA, F. T. C. R..
2013
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Liver fibrosis; Eugenia uniflora; Cytotoxicity; Cell cycle arrest; Death cell.
Ano: 2013 URL: http://www.alice.cnptia.embrapa.br/handle/doc/977990
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Mechanisms involved in the cytotoxic effects of berberine on human colon cancer HCT-8 cells Biocell
XU,Li-na; LU,Bi-nan; HU,Ming-ming; XU,You-wei; HAN,Xu; QI,Yan; PENG,Jin-yong.
Berberine, a constituent of some traditional Chinese medicinal plants, has been reported to have cytotoxicity effects on different human cancer cell lines. There is no available information about the effects and mechanism of action of berberine on human colon cancer cell line HCT-8. In this paper, the cytotoxicity of berberine on HCT-8 cancer cells was investigated by MTT assay, fluorescence microscopy and flow cytometry analysis. Our data revealed that berberine could significantly inhibit the growth of HCT-8 cells in a dose- and time-dependent manner. Morphology of apoptotic cells was studied with acridine orange/ethidium bromide staining. The concentrations of lactate dehydrogenase and both acid and alkaline phosphatases were significantly increased in...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Apoptosis; Cell cycle arrest; Death receptor pathway; Mitochondrial pathway; Natural product.
Ano: 2012 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452012000300003
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