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Beta-N-Methylamino-L-Alanine: LC-MS/MS Optimization, Screening of Cyanobacterial Strains and Occurrence in Shellfish from Thau, a French Mediterranean Lagoon ArchiMer
Reveillon, Damien; Abadie, Eric; Sechet, Veronique; Brient, Luc; Savar, Veronique; Bardouil, Michele; Hess, Philipp; Amzil, Zouher.
beta-N-methylamino-L-alanine (BMAA) is a neurotoxic non-protein amino acid suggested to be involved in neurodegenerative diseases. It was reported to be produced by cyanobacteria, but also found in edible aquatic organisms, thus raising concern of a widespread human exposure. However, the chemical analysis of BMAA and its isomers are controversial, mainly due to the lack of selectivity of the analytical methods. Using factorial design, we have optimized the chromatographic separation of underivatized analogues by a hydrophilic interaction chromatography coupled to tandem mass spectrometry (HILIC-MS/MS) method. A combination of an effective solid phase extraction (SPE) clean-up, appropriate chromatographic resolution and the use of specific mass spectral...
Tipo: Text Palavras-chave: Cyanotoxins; BMAA; DAB; AEG; HILIC-MS/MS; Cyanobacteria; Bivalve mollusks; French Mediterranean.
Ano: 2014 URL: http://archimer.ifremer.fr/doc/00245/35579/34112.pdf
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BMAA et cyanotoxines : microalgues productrices et niveaux d’accumulation dans les organismes marins ArchiMer
Reveillon, Damien.
BMAA (â-N-methylamino-L-alanine) is a non proteinogenic neurotoxic amino acid that has been associated with amyotrophic lateral sclerosis. Its analytical detection is widely debated thus the global production of BMAA by cyanobacteria is questioned. We first aimed at developing an analytical method allowing for highly selective identification of BMAA and isomers, using HILIC chromatography coupled to mass spectrometry. Then, we have cultivated and analyzed more than 50 microalgae (e.g. cyanobacteria, diatoms). Unlike DAB, one of its natural isomer, BMAA was only reported in five diatom species and cannot be accounted as a cyanotoxin anymore. In parallel, we have evaluated the presence of BMAA on the three French coasts. The presence of BMAA in different...
Tipo: Text Palavras-chave: DAB; Cyanotoxines; CL-SM/SM; Diatomées; Cyanobactéries; Bivalves; BMAA; DAB; Cyanotoxins; LC-MS/MS; Diatoms; Cyanobacteria; Bivalves.
Ano: 2015 URL: http://archimer.ifremer.fr/doc/00295/40651/39617.pdf
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Preliminary metabolomic approach on cyanobacterial co-cultures: Chemically mediated interactions between Microcystis and Planktothrix ArchiMer
Mondeguer, Florence; Sibat, Manoella; Reubrecht, Sébastien; Amzil, Zouher; Bormans, Myriam; Hess, Philipp; Briand, Enora.
Cyanobacterial proliferation is one of the most harmful hazards, in both freshwater and marine ecosystems. Cyanobacteria are well known for their ability to produce a wide variety of bioactive compounds, some of which have been described as allelochemicals. There is growing evidence that these secondary metabolites play an important role in shaping community composition through biotic interactions; however, for the most part, their biological role and mode of regulation of the production are poorly understood. In temperate eutrophic freshwaters, Microcystis and Planktothrix often co-occur, with Planktothrix being an early colonizer and Microcystis appearing subsequently. By integrating LC-MS/MS molecular networking and an innovative experimental design, we...
Tipo: Text Palavras-chave: Cyanobacteria; Cyanotoxins; Plankton interactions; Co_culture; LC_HRMS; Molecular Network; Metabolomics.
Ano: 2017 URL: http://archimer.ifremer.fr/doc/00405/51666/52215.pdf
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