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Evaluation of Gene Expression in Peripheral Blood Cells as a Potential Biomarker for Enzootic Bovine Leukosis OAK
TAWFEEQ, Mohammad Monir; HORIUCHI, Noriyuki; KOBAYASHI, Yoshiyasu; FURUOKA, Hidefumi; INOKUMA, Hisashi; 堀内, 雅之; 古林, 与志安; 古岡, 秀文; 猪熊, 壽.
Expression of six selective genes in peripheral blood cells was evaluated as diagnostic biomarkers for enzootic bovine leukosis (EBL) by using 10 EBL and 15 clinically healthy cattle. The clinically healthy cattle generally showed lower gene expression levels. Although wide variations of gene expression were found in some clinical cases of EBL, 4 and 5 among 10 EBL cattle showed higher expression of interleukin 2 receptor gene (IL2R) and Wilms’ tumor gene (WT1), respectively. Expression of IL2R in peripheral blood cells in EBL cattle was statistically increased; however, the lower sensitivity and higher variation in the gene expressions among clinical cases of EBL would be problems as diagnostic biomarkers.
Palavras-chave: Biomarkers; Enzootic bovine leukosis; Gene expression; QRT-PCR.
Ano: 2013 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3868
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慢性子宮内膜炎を呈したホルスタイン種雌牛にみられた牛白血病の1症例 OAK
竹内, 俊彦; 吉本, 薫; 駒形, 真; 福中, 守人; 古林, 与志安; 松本, 高太郎; 猪熊, 壽; TAKEUCHI, Toshihiko; YOSHIMOTO, Kaoru; KOMAGATA, Makoto; FUKUNAKA, Morito; KOBAYASHI, Yoshiyasu; MATSUMOTO, Kotaro; INOKUMA, Hisashi.
5歳5カ月齢のホルスタイン種雌牛が,発熱,食欲不振及び胎盤停滞を呈した.悪露排出及び子宮の腫脹は治療で改善がみられなかった.体表リンパ節の腫大はみられなかったが,直腸検査で子宮の硬結を認めたため,牛白血病を疑った.病理解剖では腹腔内リンパ節の腫大,胃漿膜面の腫瘤形成及び子宮壁の肥厚が認められた.また,組織所見ではこれら組織へのリンパ球様腫瘍細胞の浸潤が認められた.腫瘍細胞はB細胞マーカー陽性であった.牛白血病ウイルス(BLV)抗体は陰性であったが,末梢血のBLVプロウイルス検査では陽性が確認され,本症例におけるBLVの関与が示唆された. A 5-year-5-month old Holstein cow was presented with fever, anorexia, and retained placenta. Postnatal vaginal discharge and enlargement of the uterus did not improve after treatment. Although the superficial lymph nodes were not enlarged, enzootic bovine leukosis was suspected because of the enlarged and indurated uterus. An autopsy revealed enlargement of most abdominal lymph nodes, tumor mass formation on the omasum and abomasum, and thickening of the uterine wall. Histologically, there...
Palavras-chave: 牛白血病ウイルス; 慢性子宮内膜炎; 地方病性牛白血病; Bovine leukosis virus; Chronic endometritis; Enzootic bovine leukosis.
Ano: 2011 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/3555
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血清チミジンキナーゼ活性の測定により早期摘発した地方病性牛白血病罹患牛の1例 OAK
坂本, 礼央; 大林, 哲; 古林, 与志安; 松本, 高太郎; 石井, 三都夫; 猪熊, 壽; SAKAMOTO, Leo; OHBAYASHI, Tetsu; KOBAYASHI, Yoshiyasu; MATSUMOTO, Kotaro; ISHII, Mitsuo; INOKUMA, Hisashi.
チミジンキナーゼはDNA合成に関わる酵素の一つであり,近年牛白血病の発症マーカーとして利用できることが報 告されている.今回,牛白血病ウイルス汚染農場において,本酵素の活性を測定することにより,牛白血病罹患牛の早期摘発を試みた.その結果,臨床症状は示さなかったものの,地方病性牛白血病に罹患していた10歳9カ月齢のホルスタイン種雌牛を摘発できた.牛白血病ウイルス汚染牛群における本酵素活性の測定が,地方病性牛白血病罹患牛の早期摘発に臨床上有用であることが本研究により示唆された. Thymidine kinase is an enzyme related to DNA synthesis. Recently,serum thymidine kinase (STK) activity has been reported as a useful marker of bovine leukosis. In an effort to achieve earlier detection of enzootic bovine leukosis (EBL),we measured STK activity in cows at a farm tainted by bovine leukemia virus (BLV). We found that a Holstein cow aged 10 years and 9 months without any clinical symptoms showed higher STK activity,and the cow was diagnosed as having EBL. Evaluation of STK activity in a herd contaminated...
Palavras-chave: 地方病性牛白血病; 早期摘発; 血清チミジンキナーゼ活性; Early case detection; Enzootic bovine leukosis; Serum thymidine kinase activity.
Ano: 2010 URL: http://ir.obihiro.ac.jp/dspace/handle/10322/2942
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