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A COMPARATIVE STUDY OF BACTERIOSTATIC ACTIVITY OF SYNTHETIC HYDROXYLATED FLAVONOIDS BJM
Olivella,Mónica S.; Zarelli,Valeria E.P.; Pappano,Nora B.; Debattista,Nora B..
Among other properties, flavonoids present a notable bacteriostatic activity. In this paper, minimal inhibitory concentrations (MICs) of 5,7,4'-trihydroxyflavanone (naringenin), 5,7-dihydroxyflavone and 2',4',4- trihydroxychalcone (isoliquitirigenin) against Staphylococcus aureus ATCC 25 923 were determined and compared to values obtained for other chalcones and flavanones previously investigated. Specific growth rates and MICs were determined by a turbidimetric kinetic method. The observed sequence MICflavanone (inactive) >MIC7-hidroxyflavanone (197.6 µgml-1)>MIC5,7,4'-trihydroxyflavanone (120 µgml-1) showed that the introduction of an electron donating group (-OH) causes an increase in bioactivity. On the other hand, the comparisons...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Flavanone; Flavone; Chalcone; Bacteriostatic activity.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822001000300013
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Flavones from Erythrina falcata are modulators of fear memory. Repositório Alice
OLIVEIRA, D. R. de; ZAMBERLAM, C. R.; GAIARDO, R. B.; REGO, G. M.; CERUTTI, J. M.; CAVALHEIRO, A. J.; CERUTTI, S. M..
Background: Flavonoids, which have been identified in a variety of plants, have been demonstrated to elicit beneficial effects on memory. Some studies have reported that flavonoids derived from Erythrina plants can provide such beneficial effects on memory. The aim of this study was to identify the flavonoids present in the stem bark crude extract of Erythrina falcata (CE) and to perform a bioactivity-guided study on conditioned fear memory. Methods: The secondary metabolites of CE were identified by high performance liquid chromatography combined with a diode array detector, electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MSn) and nuclear magnetic resonance (NMR). The buthanolic fraction (BuF) was obtained by partitioning. Subfractions from...
Tipo: Artigo em periódico indexado (ALICE) Palavras-chave: Erythrina falcata; Flavona; Uso terapêutico; Memória; Medo condicionado; Flavone; Acquisition; Extinction; Fear conditioning.
Ano: 2014 URL: http://www.alice.cnptia.embrapa.br/handle/doc/999163
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