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Agmatine inhibits hypoxia-induced TNF-alpha release from cultured retinal ganglion cells Biocell
Hong,Samin; Park,Kyoungsoo; Kim,Chan Yun; Seong,Gong Je.
The effect of hypoxia on the release of tumor necrosis factor-alpha (TNF-alpha) in transformed rat retinal ganglion cells (RGCs) and the effect of agmatine on the hypoxia-induced production of TNF-alpha in RGCs were evaluated. RGCs were cultured under hypoxic conditions with 5% oxygen, with or without 100μM agmatine. The expression levels of TNF-alpha and its receptor-1 (TNF-R1) were investigated by Western blot analysis. After 6 hours of hypoxia, we noted an increase in TNF-alpha production in RGCs. Agmatine significantly reduced TNF-alpha level after 12 hours of hypoxic treatment. The expression of TNF-R1 was not affected by the hypoxia or agmatine treatment. Our results show that agmatine inhibits the TNF-alpha production of RGCs in hypoxic...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Retinal ganglion cell; Tumor necrosis factor-alpha; Hypoxia; Agmatine.
Ano: 2008 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452008000200006
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Agricultural Drainage and Gulf Hypoxia: Economic Targeting of Farmland to Reduce Nitrogen Loads in a Minnesota Watershed AgEcon
Petrolia, Daniel R.; Gowda, Prasanna H.; Mulla, David J..
Agricultural nitrogen losses are the major contributor to nitrogen loads in the Mississippi River, and consequently, to the existence of a hypoxic, or "dead", zone in the Gulf of Mexico. Focusing on two small agricultural watersheds in southwestern Minnesota, simulation results from the Agricultural Drainage And Pesticide Management (ADAPT) model were combined with a linear-optimization model to evaluate the environmental and economic impact of alternative land-use policies for reducing nitrogen losses. Of particular importance was the study's explicit focus on agricultural subsurface (tile) drainage, which has been identified as the major pathway for agricultural nitrogen losses in the upper Midwest, and the use of drainage-focused abatement policies....
Tipo: Conference Paper or Presentation Palavras-chave: Drainage; Hypoxia; ADAPT; Nitrogen; Watershed; Environmental Economics and Policy.
Ano: 2005 URL: http://purl.umn.edu/19416
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An Analysis of the Role of Tile-Drained Farmland Under Alternative Nitrogen Abatement Policies AgEcon
Petrolia, Daniel R.; Gowda, Prasanna H..
Agricultural nitrogen is a major contributor to Gulf of Mexico hypoxia, and research has shown that agricultural subsurface tile drainage is a major carrier of nitrogen from croplands to streams and rivers. This study compares the results of abating nitrogen under a retired-land minimization policy with those of a new revenue-maximizing policy, paying particular attention to the role of tile-drained land. Findings reveal the retirement-minimizing policy resulted in more tile-drained land being retired and less being fertilizer-managed than was optimal under the net-return maximizing policy. Also, it led to a greater economic burden being shouldered by tile-drained land. Under both cases, tile drainage dominated the abatement process.
Tipo: Journal Article Palavras-chave: Abatement; ADAPT; Drainage; Hypoxia; Nitrogen; Crop Production/Industries; Land Economics/Use.
Ano: 2006 URL: http://purl.umn.edu/8621
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An early-life hypoxia event has a long-term impact on protein digestion and growth in European sea bass juvenile. ArchiMer
Zambonino, Jose-luis; Mazurais, David; Dubuc, Alexia; Queau, Pierre; Vanderplancke, Gwenaelle; Servili, Arianna; Cahu, Chantal; Le Bayon, Nicolas; Huelvan, Christine; Claireaux, Guy.
Ocean warming, eutrophication and consequent decrease in oxygen lead to smaller average fish size. Although such responses are well-known in an evolutionary context, involving multiple generations, it appears to be incompatible with current rapid environmental change. Rather, phenotypic plasticity could provide a means for marine fish to cope with rapid environmental changes. However, little is known about the mechanisms underlying plastic responses to environmental conditions that favour small phenotypes. Our aim was to investigate how and why European sea bass that had experienced a short episode of moderate hypoxia during their larval stage subsequently exhibited a growth depression at the juvenile stage compared to the control group. We examined...
Tipo: Text Palavras-chave: Climate change; Digestive enzymes; Dicentrarchus labrax; Growth; Hypoxia; Respirometry.
Ano: 2017 URL: http://archimer.ifremer.fr/doc/00373/48407/48635.pdf
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Anatomia ecológica de Sebastiania commersoniana (Baillon) Smith & Downs (Euphorbiaceae) submetida ao alagamento Rev. Bras. Bot.
KOLB,ROSANA M.; MEDRI,MOACYR E.; BIANCHINI,EDMILSON; PIMENTA,JOSÉ A.; GILONI,PATRICIA C.; CORREA,GERALDO T..
Em matas ciliares da Bacia Hidrográfica do Rio Tibagi, nas áreas sujeitas a inundações periódicas, é comum a ocorrência de S. commersoniana onde, geralmente, se torna a espécie dominante. A fim de elucidar alguns aspectos de tolerância ao alagamento, plantas dessa espécie foram mantidas na capacidade de campo e em solo alagado por dois meses. Após esse período, algumas plantas foram desalagadas para verificar o comportamento da espécie no período de reaeração. O alagamento induziu, em raízes, aumento de espaços intercelulares, redução na espessura do cilindro central e aumento na espessura do córtex. Plantas alagadas cresceram menos que as controle e desenvolveram lenticelas hipertróficas caulinares e algumas raízes adventícias. Plantas reaeradas retomaram...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ecological anatomy; Hypoxia; Sebastiania commersoniana.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84041998000300010
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Assessing chronic fish health: An application to a case of an acute exposure to chemically treated crude oil ArchiMer
Mauduit, Florian; Domenici, P.; Farrell, A. P.; Lacroix, C.; Le Floch, S.; Lemaire, P.; Nicolas-kopec, A.; Whittington, M.; Zambonino-infante, Jose-luis; Claireaux, Guy.
Human alteration of marine ecosystems is substantial and growing. Yet, no adequate methodology exists that provides reliable predictions of how environmental degradation will affect these ecosystems at a relevant level of biological organization. The primary objective of this study was to develop a methodology to evaluate a fish’s capacity to face a well-established environmental challenge, an exposure to chemically dispersed oil, and characterize the long-term consequences. Therefore, we applied high-throughput, non-lethal challenge tests to assess hypoxia tolerance, temperature susceptibility and maximal swimming speed as proxies for a fish’s functional integrity. These whole animal challenge tests were implemented before (1 month) and after (1 month)...
Tipo: Text Palavras-chave: Fish; Oil spill; Dispersant; Biomarkers; Physiological integrity; Ecological performance; Temperature; Hypoxia; Swimming; Growth.
Ano: 2016 URL: http://archimer.ifremer.fr/doc/00347/45828/45916.pdf
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Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives Biol. Res.
GAMBOA,JORGE; CACEDA,RICARDO; GAMBOA,ALFREDO; MONGE-C,CARLOS.
Red blood cell carbonic anhydrase (CA) activity has not been studied in high altitude natives. Because CA is an intraerythocytic enzyme and high altitude natives are polycythemic, it is important to know if the activity of CA per red cell volume is different from that of their sea level counterparts. Blood was collected from healthy subjects living in Lima (150m) and from twelve subjects from Cerro de Pasco (4330m), and hematocrit and carbonic anhydrase activity were measured. As expected, the high altitude natives had significantly higher hematocrits than the sea level controls (p=0.0002). No difference in the CA activity per milliliter of red cells was found between the two populations. There was no correlation between the hematocrit and CA activity.
Tipo: Journal article Palavras-chave: Carbonic anhydrase; Hypoxia; Polycythemia.
Ano: 2000 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300006
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Cardiovascular, respiratory and metabolic responses to temperature and hypoxia of the winter frog Rana catesbeiana BJMBR
The objective of the present study was to determine the effects of hypoxia and temperature on the cardiovascular and respiratory systems and plasma glucose levels of the winter bullfrog Rana catesbeiana. Body temperature was maintained at 10, 15, 25 and 35oC for measurements of breathing frequency, heart rate, arterial blood pressure, metabolic rate, plasma glucose levels, blood gases and acid-base status. Reducing body temperature from 35 to 10oC decreased (P<0.001) heart rate (bpm) from 64.0 ± 3.1 (N = 5) to 12.5 ± 2.5 (N = 6) and blood pressure (mmHg) (P<0.05) from 41.9 ± 2.1 (N = 5) to 33.1 ± 2.1 (N = 6), whereas no significant changes were observed under hypoxia. Hypoxia-induced changes in breathing frequency and acid-base status were...
Tipo: Info:eu-repo/semantics/other Palavras-chave: Temperature; Hypoxia; Rana; Breathing frequency; Blood pressure; Heart rate; Acid-base status; Hyperglycemia.
Ano: 1997 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1997000100019
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Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia BJMBR
Marshall,J.M..
This review describes the ways in which the primary bradycardia and peripheral vasoconstriction evoked by selective stimulation of peripheral chemoreceptors can be modified by the secondary effects of a chemoreceptor-induced increase in ventilation. The evidence that strong stimulation of peripheral chemoreceptors can evoke the behavioural and cardiovascular components of the alerting or defence response which is characteristically evoked by novel or noxious stimuli is considered. The functional significance of all these influences in systemic hypoxia is then discussed with emphasis on the fact that these reflex changes can be overcome by the local effects of hypoxia: central neural hypoxia depresses ventilation, hypoxia acting on the heart causes...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoxia; Adenosine; Chemoreceptors; Vasodilatation; Noradrenaline.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000700002
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Cobalt chloride stimulates phosphoinositide 3-kinase/Akt signaling through the epidermal growth factor receptor in oral squamous cell carcinoma Biocell
Heon Ryu,Mi; Hee Park,Jeong; Eun Park,Ji; Chung,Jin; Hun Lee,Chang; Ryoun Park,Hae.
Tumor cells are often found under hypoxic conditions due to the rapid outgrowth of their vascular supply, and, in order to survive hypoxia, these cells induce numerous signaling factors. Akt is an important kinase in cell survival, and its activity is regulated by the upstream phosphoinositide 3-kinase (PI3K) and receptor tyrosine kinases (RTKs). In this study, we examined Akt activation and RTKs/PI3K/Akt signaling using the hypoxia-mimetic cobalt chloride in oral squamous carcinoma cells. Cobalt chloride increases Akt phosphorylation in both a dose- and time-dependent manner. Blocking the activation of the PI3K/Akt pathway using LY294002 abolished Akt activation in response to cobalt chloride, suggesting that Akt phosphorylation by cobalt chloride is...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypoxia; DNA synthesis; S-phase.
Ano: 2010 URL: http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0327-95452010000100003
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Comparative effects of long-term hypoxia on growth, feeding and oxygen consumption in juvenile turbot and European sea bass ArchiMer
Pichavant, Karine; Person, Jeannine; Le Bayon, Nicolas; Severe, Armelle; Le Roux, Annick; Boeuf, Gilles.
When juvenile turbot Scophthulmus maximus and sea bass Dicentrarchus labrax were fed to satiation, growth and food intake were depressed under hypoxia (3.2 +/- 0.3 and 4.5 +/- 0.2 mg O-2 l(-1)). However, no significant difference in growth was observed between fishes maintained in hypoxia and fed to satiation and fishes reared in normoxia (7.4 +/- 0.3 mg O-2 l(-1)) and fed restricted rations (same food intake of fishes at 3.2 mg O-2 l(-1)). Routine oxygen consumption of fishes fed to satiation was higher in normoxia than in hypoxia due to the decrease in food intake in the latter. Of the physiological parameters measured, no significant changes were observed in the two species maintained in hypoxia. This study confirms the significant interaction between...
Tipo: Text Palavras-chave: Oxygen consumption; Growth; Hypoxia; Sea bass; Turbot.
Ano: 2001 URL: http://archimer.ifremer.fr/doc/2001/publication-617.pdf
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Conséquences à long terme d'une exposition précose à l'hypoxie sur la physiologie du bar européen (Dicentrarchus labrax) et de la sole commune (Solea solea) ArchiMer
Vanderplancke, Gwenaelle.
The dissolved oxygen in seawater has steadily declined in many coastal marine ecosystems in the last 50 years because of global warming and increasing coastal human activities. This decrease in oxygen in seawater causes episodes of hypoxia increasingly frequent and severe in coastal and estuarine areas. Some organisms may escape these environmental constraints by migration or dispersion. Others, with limited swimming capabilities must implement physiological regulation (phenotypic plasticity) to enable them to adapt and survive. This is particularly the case of marine fish larvae that are likely to be present in coastal nursery at the end of their development. It is now well established that the regulations implemented by organisms to cope with their...
Tipo: Text Palavras-chave: Hypoxie; Conditionnement; Programmation environnementale; Poissons marins; Changement climatique; Oxygène; Dicentrarchus labrax; Solea solea; Marine fish; Climate change; Oxygen; Hypoxia; Conditioning; Environmental programming.
Ano: 2015 URL: https://archimer.ifremer.fr/doc/00498/60938/64332.pdf
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Consommation d'oxygene de la crevette japonaise, Penaeus japonicus , en fonction de l'oxygenation du milieu: Effects de la temperature et de l'acclimatation a des conditions ambiantes hypoxiques ArchiMer
Truchot, J; Jouve, D.
Oxygen consumption of juvenile prawns, Penaeus japonicus , was measured during the day at 4 temperatures (23, 26, 30 and 33 degree C) and at various oxygenation levels. For inactive prawns burrowed into sand, respiratory metabolism was maintained almost constant in hypoxia above a critical oxygen pressure of about 30-40 Torr. Data analysis according to a hyperbolic model indicates that the capacity for metabolic regulation was optimal between 26 and 30 degree C. Prawns acclimated 1-2 weeks at 20 degree C in moderate hypoxia (P sub(O2) around 50-55 Torr) showed a reinforced regulation of oxygen consumption when compared to normoxic controls.
Tipo: Text Palavras-chave: Penaeus japonicus; Malacostraca; Juveniles; Respiration; Hypoxia; Dissolved oxygen; Temperature effects; Oxygen consumption; Crevettes Pénaeides; Température; Hypoxie; Métabolisme respiratoire.
Ano: 1983 URL: http://archimer.ifremer.fr/doc/1983/acte-1192.pdf
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Cross-shelf biogeochemical characteristics of sediments in the central Benguela and their relationship to overlying water column hypoxia OceanDocs
Monteiro, P.M.S.; Van Der Plas, Anja; Pascall, A..
Data from two cross-shelf sediment sampling cruises were used to explain reasons for the sediment biogeochemical variability in respect of carbon, nitrogen and sulphur, and how the cycling of these elements governs the biogeochemistry of the overlying water through their control of the redox conditions. The spatial extent of this benthic–pelagic flux link is limited to the innershelf mud belt system on the Namibian shelf. The inshore mud belt is the primary deposition area of the carbon and nitrogen new production export flux. The offshore organic-rich zones are thought to be relict particulate organic matter originating from the inshore mud belt rather than from an overlying pelagic source. These data were used to set up a multi-layer sediment model that...
Tipo: Journal Contribution Palavras-chave: Anoxia; Carbon; Hypoxia; Modelling; Sediments; Carbon; Anoxia; Hypoxia; Http://aims.fao.org/aos/agrovoc/c_1301; Http://aims.fao.org/aos/agrovoc/c_8831; Http://aims.fao.org/aos/agrovoc/c_24472.
Ano: 2007 URL: http://hdl.handle.net/1834/2129
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Early exposure to chronic hypoxia induces short- and long-term regulation of hemoglobin gene expression in European sea bass (Dicentrarchus labrax) ArchiMer
Cadiz, Laura; Servili, Arianna; Quazuguel, Patrick; Madec, Lauriane; Zambonino, Jose-luis; Mazurais, David.
European sea bass (Dicentrarchus labrax) inhabits coastal waters and may be exposed to hypoxia at different life stages, requiring physiological and behavioral adaptation. In the present study, we attempted to determine whether regulation of hemoglobin (Hb) gene expression plays a role in the physiological response to chronic moderate hypoxia in whole larvae and hematopoietic tissues (head kidney and spleen) of juveniles. We also tested the hypothesis that hypoxia exposure at the larval stage could induce a long-term effect on the regulation of Hb gene expression. For this purpose, D. labrax were exposed to a non-lethal hypoxic condition (40% air saturation) at the larval stage from 28 to 50 days post-hatching (dph) and/or at the juvenile stage from 196 to...
Tipo: Text Palavras-chave: Hypoxia; Hemoglobin; Early exposure; European sea bass.
Ano: 2017 URL: http://archimer.ifremer.fr/doc/00399/51039/51831.pdf
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Ecophysiology and respiratory metabolism during the germination of Inga sessilis (Vell.) Mart. (Mimosaceae) seeds subjected to hypoxia and anoxia Rev. Bras. Bot.
OKAMOTO,JANETE MAYUMI; JOLY,CARLOS ALFREDO.
This paper presents a study on the respiratory metabolism of germinating seeds of Inga sessilis subjected to normoxia, hypoxia and anoxia. Although it is typical of environments where waterlogging seldom occurs, 40% of its seeds are able to germinate under hypoxia; yet, anoxia periods over 96 h are lethal to the seeds. Ethanol is the main product of the seeds anaerobic metabolism, but the steep increase in lactate after 24 h anoxia or 48 h hypoxia may explain the drop in seed viability.
Tipo: Info:eu-repo/semantics/article Palavras-chave: Inga sessilis; Germination; Respiratory metabolism; Hypoxia; Anoxia.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-84042000000100006
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Effect of High Altitude Hypoxia on the Postnatal Development of Rat Testis: Histological and Histometric Study International Journal of Morphology
Mohammed,Heitham Mutwakil; Tingari,M. D.
The study was carried out at two different altitudes in the southern region of Saudi Arabia: Abha, 2,800 meters above sea level, the high altitude (HA) area and Jazan, 40 meters above sea level the low altitude (LA) area. Following exposure to high altitude, and up to the third week of postnatal development, some of the seminiferous tubules showed detachment from the basal lamina, spaces of different sizes within the epithelial layer with vacuoles in the center and Pyknotic nuclei were noted in the spermatogonia and primordial germ cells. Rounded spermatids were seen in the lumen only on day 35 of hypoxic group, no spermatozoa were recognized until day 45 of postnatal development. On day 45 hypoxic rat testes revealed various types of atrophy and...
Tipo: Journal article Palavras-chave: High altitude; Low altitude; Hypoxia.
Ano: 2016 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022016000200031
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Effect of hypoxia on the activity and binding of glycolytic and associated enzymes in sea scorpion tissues BJMBR
Lushchak,V.I.; Bahnjukova,T.V.; Storey,K.B..
The effect of hypoxia on the levels of glycogen, glucose and lactate as well as the activities and binding of glycolytic and associated enzymes to subcellular structures was studied in brain, liver and white muscle of the teleost fish, Scorpaena porcus. Hypoxia exposure decreased glucose levels in liver from 2.53 to 1.70 µmol/g wet weight and in muscle led to its increase from 3.64 to 25.1 µmol/g wet weight. Maximal activities of several enzymes in brain were increased by hypoxia: hexokinase by 23%, phosphoglucoisomerase by 47% and phosphofructokinase (PFK) by 56%. However, activities of other enzymes in brain as well as enzymes in liver and white muscle were largely unchanged or decreased during experimental hypoxia. Glycolytic enzymes in all three...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Fish; Sea scorpion; Scorpaena porcus; Hypoxia; Metabolites; Glycolytic enzyme binding.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000800005
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Effects of Chronic Simulated Hypobaric Hypoxia on Mouse Spermatogenesis International Journal of Morphology
Bustos-Obregón,Eduardo; Esveile,Christian; Contreras,Julio; Maurer,Inge; Sarabia,Luis.
Reduction of O2 delivery to tissues damage them, including the seminiferous epithelium. Recently, population working in high altitude has increased, so that the study of hypobaric hypoxia on spermatogenesis becomes of interest. In this study we used two groups of male, sexually mature mice Control (C) (540 meters above sea level (masl)) and chronic simulated hypobaric hypoxia (CSHH) (4,600 masl) exposed during 8, 16, 24 or 33 days. Hematocrit; reticulocytosis; testicular, epididymal and seminal vesicle weight; seminiferous epithelium height, tubular diameter, sperm count and morphology and testicular parenchyme and spermatozoa membranes lipoperoxidation were measured. Weight of testis, epididymis and seminal vesicle were reduced but they recuperate at 33...
Tipo: Journal article Palavras-chave: Hypoxia; Lipoperoxidation; Mouse; Testis.
Ano: 2006 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022006000400030
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Effects of extended absence of flooding on the fish assemblages of three floodplain lagoons in the middle São Francisco River, Brazil Neotropical Ichthyology
Pompeu,Paulo dos Santos; Godinho,Hugo Pereira.
In the Neotropics, a large proportion of fish communities of large rivers use floodplain as habitats for feeding, reproduction, and refuge. An evaluation was made of the effects of extended dry periods on the species richness, abundance and local extinction of fish species in three marginal lagoons in the middle São Francisco River, southeastern Brazil. The studied lagoons fail to receive river floods during the study period (1994-1996). A gradual reduction in richness and abundance was observed in all lagoons. Migratory fish species had the highest probability to become extinct in the two lagoons that remained with large water volume. Species tolerant to low levels of dissolved oxygen had the lowest probability of local extinction in the lagoon showing an...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Floodplain; Migratory fish; Extended drought; Hypoxia.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1679-62252006000400006
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