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Are the beneficial cardiovascular effects of simvastatin and metformin also associated with a hormone-dependent mechanism improving insulin sensitivity? BJMBR
Bulcão,C.; Giuffrida,F.M.A.; Ribeiro-Filho,F.F.; Ferreira,S.R.G..
In addition to lipid-lowering and cardiovascular protective actions, statins may have beneficial effects on insulin sensitivity. The objective of the present study was to evaluate the effect of simvastatin therapy on insulin resistance and on leptin, adiponectin, and C-reactive protein (CRP) levels, as compared to metformin, in overweight pre-diabetic subjects. Forty-one subjects with BMI >25 kg/m² and impaired fasting glucose or impaired glucose tolerance were randomized to take simvastatin, 20 mg/day (N = 20) or metformin, 1.7 g/day (N = 21) for 16 weeks. Blood samples for the determination of metabolic, hormonal, and inflammatory parameters were obtained at baseline and after each treatment. After metformin therapy, significant reductions in mean BMI...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Simvastatin; Metformin; Insulin resistance; Leptin; Adiponectin.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000200009
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Association between molecular markers linked to the Leptin gene and weight gain in postpartum beef cows Ciência Rural
Almeida,Sabrina Esteves Matos; Almeida,Erik Amazonas de; Terra,Gustavo; Neves,Jairo Pereira; Gonçalves,Paulo Bayard Dias; Weimer,Tania de Azevedo.
Three short tandem repeats (STRs), BMS1074, BM1500, IDVGA-51, and three single nucleotide polymorphisms (SNPs), LEPSau3AI (A/B), LEPSau3AI (+/-) and LEPKpn2I linked to the LEP gene were investigated to verify associations with productive performance in postpartum cows of two beef cattle breeds, Aberdeen Angus (AA, n=98) and Charolais (C, n=83). After polymerase chain reaction, STRs were analyzed by vertical electrophoresis and SNPs in agarose gel after endonucleases cleavage. In AA herd 79% of BMS1074*151 carriers had a lower average daily weight gain (ADG) when compared with the population mean daily weight gain (103g), while 62% of BMS1074*151 non-carriers presented a higher ADG (P<0.01); AA animals with at least one BMS1074*151 allele showed a ADG...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leptin; STRs; SNPs; Beef cattle; Weight gain; Post-partum.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782007000100033
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Behavioral changes induced by cocaine in mice are modified by a hyperlipidic diet or recombinant leptin BJMBR
Erhardt,E.; Zibetti,L.C.E.; Godinho,J.M.; Bacchieri,B.; Barros,H.M.T..
The objective of the present study was to determine if the acute behavioral effects of cocaine acutely administered intraperitoneally (ip) at doses of 5, 10 and 20 mg/kg on white male CF1 mice, 90 days of age, would be influenced by leptin acutely administered ip (at doses of 5, 10 and 20 µg/kg) or by endogenous leptin production enhanced by a high-fat diet. The acute behavioral effects of cocaine were evaluated in open-field, elevated plus-maze and forced swimming tests. Results were compared between a group of 80 mice consuming a balanced diet and a high-fat diet, and a group of 80 mice fed a commercially available rodent chow formula (Ralston Purina) but receiving recombinant leptin (rLeptin) or saline ip. Both the high-fat-fed and rLeptin-treated mice...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Mice; Cocaine; Leptin; Hyperlipidic diet; Interaction.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001200014
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Economic Value of Selecting and Marketing Cattle by Leptin Genotype AgEcon
Lusk, Jayson L..
Recent research has identified genetic diversity in the ability of animals to manufacture and recognize leptin, a protein that regulated appetite and weight. This paper determines the economic value of using information on leptin genotype to select and manage beef cattle. Results reveal that the economic value of using genotypic information to sort cattle by optimal endpoint is only about $2/head for steers and $1/head for heifers; however, the value of using genotypic information to optimally select and feed only certain genotypes is $23/head for steers and $28/head for heifers. The difference in per head profit between the best and worst performing genotype is over $28 on the date the cattle were actually marketed and increases to $60 if each genotype is...
Tipo: Journal Article Palavras-chave: Cattle marketing; Days on feed; Genetics; Growth models; Leptin; Value of information; Livestock Production/Industries.
Ano: 2007 URL: http://purl.umn.edu/8641
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Effects of long-term consumption of high fructose corn syrup containing peach nectar on body weight gain in sprague dawley rats Ciênc. Tecnol. Aliment.
OZCAN SINIR,Gulsah; SUNA,Senem; INAN,Sevda; BAGDAS,Deniz; TAMER,Canan Ece; COPUR,Omer Utku; SIGIRLI,Deniz; SARANDOL,Emre; SONMEZ,Gursel; ERCAN,Ilker; EVRENSEL,Turkkan; TARIM,Omer Faruk; EREN,Erdal; UYLASER,Vildan; INCEDAYI,Bige.
Abstract High fructose corn syrup (HFCS) is one of the most used sweeteners in the food industry. Health concerns regarding the consumption of HFCS-containing foods have developed in parallel with the increasing amount of people who become overweight. This study was conducted to investigate whether HFCS-containing peach nectar (pn-HFCS) consumption has more detrimental effects on anthropometrical and biochemical parameters compared with sucrose-containing peach nectar (pn-sucrose). Fifty-day-old Sprague Dawley rats were divided into three groups and were fed (A) pn-HFCS + ad libitum chow, (B) pn-sucrose + ad libitum chow and (C) only ad libitum chow for 7 months. The percentage change in body weight (PCBW), body mass index (BMI), and Lee index were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: HFCS; Weight gain; Insulin; Leptin; BMI; Peach nectar.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0101-20612017000200337
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Estradiol-induced hypophagia is associated with the differential mRNA expression of hypothalamic neuropeptides BJMBR
Silva,L.E.C.M.; Castro,M.; Amaral,F.C.; Antunes-Rodrigues,J.; Elias,L.L.K..
Estradiol participates in the control of energy homeostasis, as demonstrated by an increase in food intake and in body weight gain after ovariectomy in rats. In the present study, female Wistar rats (200-230 g, N = 5-15 per group), with free access to chow, were individually housed in metabolic cages. We investigated food intake, body weight, plasma leptin levels, measured by specific radioimmunoassay, and the hypothalamic mRNA expression of orexigenic and anorexigenic neuropeptides, determined by real-time PCR, in ovariectomized rats with (OVX+E) and without (OVX) estradiol cypionate treatment (10 µg/kg body weight, sc, for 8 days). Hormonal and mRNA expression were determined at pre-feeding and 4 h after food intake. OVX+E rats showed lower food intake,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Estradiol; Leptin; Orexigenic and anorexigenic neuropeptides; Hypothalamus.
Ano: 2010 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010000800009
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Ferulic acid lowers body weight and visceral fat accumulation via modulation of enzymatic, hormonal and inflammatory changes in a mouse model of high-fat diet-induced obesity BJMBR
de Melo,T.S.; Lima,P.R.; Carvalho,K.M.M.B.; Fontenele,T.M.; Solon,F.R.N.; Tomé,A.R.; de Lemos,T.L.G.; da Cruz Fonseca,S.G.; Santos,F.A.; Rao,V.S.; de Queiroz,M.G.R..
Previous studies have reported on the glucose and lipid-lowering effects of ferulic acid (FA) but its anti-obesity potential has not yet been firmly established. This study investigated the possible anti-obesitogenic effects of FA in mice fed a high-fat diet (HFD) for 15 weeks. To assess the antiobesity potential of FA, 32 male Swiss mice, weighing 20–25 g (n=6–8 per group) were fed a normal diet (ND) or HFD, treated orally or not with either FA (10 mg/kg) or sibutramine (10 mg/kg) for 15 weeks and at the end of this period, the body weights of animals, visceral fat accumulation, plasma levels of glucose and insulin hormone, amylase and lipase activities, the satiety hormones ghrelin and leptin, and tumor necrosis factor-α (TNF-α) and monocyte...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Ferulic acid; Anti-obesity; High-fat diet; Leptin; Lipase; Tumor necrosis factor-α.
Ano: 2017 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2017000100603
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Influence of dexamethasone and weight loss on the regulation of serum leptin levels in obese individuals BJMBR
Lerario,D.D.G.; Ferreira,S.R.G.; Miranda,W.L.; Chacra,A.R..
The adipocyte hormone leptin is thought to serve as a signal to the central nervous system reflecting the status of fat stores. Serum leptin levels and adipocyte leptin messenger RNA levels are clearly increased in obesity. Nevertheless, the factors regulating leptin production are not fully understood. The aim of this study was to determine the effects of in vivo administration of the synthetic glucocorticoid dexamethasone and weight loss on serum leptin levels in two independent protocols. Twenty-five obese subjects were studied (18 women and 7 men, mean age 26.6 ± 6 years, BMI 31.1 ± 2.5 kg/m², %fat 40.3 ± 8.3) and compared at baseline to 22 healthy individuals. Serum levels of leptin, insulin, proinsulin and glucose were assessed at baseline and after...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Leptin; Weight reduction; Dexamethasone.
Ano: 2001 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400007
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Leptin and adiponectin in the female life course BJMBR
Lecke,S.B.; Morsch,D.M.; Spritzer,P.M..
Adipose tissue secretes a variety of adipokines, including leptin and adiponectin, which are involved in endocrine processes regulating glucose and fatty metabolism, energy expenditure, inflammatory response, immunity, cardiovascular function, and reproduction. The present article describes the fluctuations in circulating leptin and adiponectin as well as their patterns of secretion in women from birth to menopause. During pregnancy, leptin and adiponectin seem to act in an autocrine/paracrine fashion in the placenta and adipose tissue, playing a role in the maternal-fetal interface and contributing to glucose metabolism and fetal development. In newborns, adiponectin levels are two to three times higher than in adults. Full-term newborns have...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Female; Adiposity; Leptin; Adiponectin.
Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000500001
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Leptin and hypothalamic gene expression in early- and late-maturing Bos indicus Nellore heifers Genet. Mol. Biol.
Vaiciunas,Aline; Coutinho,Luiz L.; Meirelles,Flávio V.; Pires,Alexandre V.; Silva,Luis Felipe P..
We investigated wether early-maturing or late-maturing Bos indicus Nellore heifers produced more leptin mRNA in adipose tissues and altered expression of hypothalamic genes related to leptin signaling. Six prepubertal and six pubertal heifers aged about 34 months and weighing 280 kg to 300 kg each were selected from a population of 100 Nellore heifers. Real-time PCR was used to quantify the expression of the leptin gene (LEP) in adipose tissues and the long isoform of the leptin receptor gene (Ob-Rb), the NK2 homeobox 1 hypothalamic marker gene NKX2-1, the suppressor of cytokine signaling 3 gene (SOCS-3), the neuropeptide Y genes (NPY) and the NPY G-protein coupled receptor genes NPY-Y1 and NPY-Y4 in the hypothalamus. Heifers attaining puberty earlier...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Bos indicus; Gene expression; Hypothalamus; Leptin; Neuropeptide Y.
Ano: 2008 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400010
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Leptin is not associated independently with hypertension in Japanese-Brazilian women BJMBR
Almeida-Pititto,B.; Gimeno,S.G.A.; Freire,R.D.; Ribeiro-Filho,F.F.; Ferreira,S.R.G..
We evaluated the relationship of leptin with hypertension adjusted for body mass index (BMI) and/or waist circumference in a population of Japanese-Brazilian women aged > or = 30 years with centrally distributed adiposity. After excluding diabetic subjects, the study subjects - who participated in a population-based study on the prevalence of metabolic syndrome - showed prevalence rates of obesity (BMI > or = 25 kg/m²) and central adiposity (waist > or = 80 cm) of 32.0 and 37.8%, respectively. The hypertensive group (N = 162) was older, had higher BMI (24.9 ± 4.2 vs 23.3 ± 3.4 kg/m², P < 0.001), waist circumference (81.1 ± 10.1 vs 76.3 ± 8.2 cm, P < 0.001) and insulin levels (8.0 ± 6.2 vs 7.1 ± 4.9 µU/mL, P < 0.05) than the...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Hypertension; Body fat distribution; Insulin; Leptin; Centrally obese; Metabolic syndrome.
Ano: 2006 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006000100012
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Leptin levels in different forms of Chagas' disease BJMBR
Fernandes,F.; Dantas,S.; Ianni,B.M.; Ramires,F.J.A.; Buck,P.; Salemi,V.M.C.; Lopes,H.F.; Mady,C..
Leptin is produced primarily by adipocytes. Although originally associated with the central regulation of satiety and energy metabolism, increasing evidence indicates that leptin may be an important mediator in cardiovascular pathophysiology. The aim of the present study was to investigate plasma leptin levels in patient with Chagas' heart disease and their relation to different forms of the disease. We studied 52 chagasic patients and 30 controls matched for age and body mass index. All subjects underwent anthropometric, leptin and N-terminal pro-brain natriuretic peptide (NT-proBNP) measurements and were evaluated by echocardiography, 12-lead electrocardiogram (ECG), and chest X-ray. All patients had fasting blood samples taken between 8:00 and 9:00 am....
Tipo: Info:eu-repo/semantics/article Palavras-chave: Chagas' disease; Leptin; Heart failure; Left ventricular failure.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007001200006
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Leptin receptor (Ob-R) mRNA expression and serum leptin concentration in patients with colorectal and metastatic colorectal cancer BJMBR
Erkasap,N.; Ozkurt,M.; Erkasap,S.; Yasar,F.; Uzuner,K.; Ihtiyar,E.; Uslu,S.; Kara,M.; Bolluk,O..
The objective of the present study was to investigate the effect of leptin on the progression of colorectal carcinoma to metastatic disease by analyzing the serum leptin concentration and Ob-R gene expression in colon cancer tissues. Tissue samples were obtained from 31 patients who underwent surgical resection for colon (18 cases) and metastatic colon (13 cases) cancer. Serum leptin concentration was determined by an enzyme-linked immunosorbent assay (ELISA) and Ob-R mRNA expression by real-time polymerase chain reaction (RT-PCR) for both groups. ELISA data were analyzed by the Student t-test and RT-PCR data were analyzed by the Mann-Whitney U-test. RT-PCR results demonstrated that mRNA expression of Ob-R in human metastatic colorectal cancer was higher...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leptin; Colorectal cancer; Metastatic colorectal cancer; Leptin receptor (Ob-R); Real-time PCR.
Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300306
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Malnutrition during lactation as a metabolic imprinting factor inducing the feeding pattern of offspring rats when adults: The role of insulin and leptin BJMBR
Moura,A.S.; Franco de Sá,C.C.N.; Cruz,H.G.; Costa,C.L..
The aim of the present study was to determine the impact of malnutrition during early postnatal life and the feeding pattern of rat offspring when adults (2 months and 1 year old). In comparison with rats normally fed during lactation, we observed that adult offspring displayed a faster process of feeding reduction when a protein-free diet was offered. In addition, we studied the concentration of insulin and leptin in the lactating pups (10 days) and when these offspring became adult after the onset of a new feeding pattern induced by the protein-free diet. When the diet was changed at 60 days, the offspring malnourished during lactation displayed, after 3 days, a food intake reduction around 41.4 vs 14.2% of the control group. At 10 days of life, plasma...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Nutrition; Growth; Insulin; Leptin.
Ano: 2002 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000500016
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Microcirculation in obesity: an unexplored domain Anais da ABC (AABC)
Wiernsperger,Nicolas; Nivoit,Pierre; Bouskela,Eliete.
Obesity is traditionally linked to diabetes and cardiovascular diseases. Very recent experimental, clinical and epidemiological, sometimes provocative, data challenge this automaticity by showing that not the amount but the distribution of fat is the important determinant. Moderate abdominal fat accumulation may thus be more harmful than even consequent overweight. In view of the worldwide burden of obesity, factors leading to it in children and young adults must urgently be identified. Since obesity is a very complex cardiometabolic situation, this will require to focus investigations on uncomplicated obese subjects and adequate animal models. The recent discovery of intergenerational transmissions of obesity risk factors and also the key role played by...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Cardiovascular disease; Diabetes mellitus; Birth weight; Metabolic syndrome; Leptin.
Ano: 2007 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652007000400005
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Pivotal role of leptin in insulin effects BJMBR
Ceddia,R.B.; William Jr.,W.N.; Lima,F.B.; Carpinelli,A.R.; Curi,R..
The OB protein, also known as leptin, is secreted by adipose tissue, circulates in the blood, probably bound to a family of binding proteins, and acts on central neural networks regulating ingestive behavior and energy balance. The two forms of leptin receptors (long and short forms) have been identified in various peripheral tissues, a fact that makes them possible target sites for a direct action of leptin. It has been shown that the OB protein interferes with insulin secretion from pancreatic islets, reduces insulin-stimulated glucose transport in adipocytes, and increases glucose transport, glycogen synthesis and fatty acid oxidation in skeletal muscle. Under normoglycemic and normoinsulinemic conditions, leptin seems to shift the flux of metabolites...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leptin; Insulin secretion; Muscle metabolism; Insulin resistance; Adipocytes.
Ano: 1998 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000600001
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Positive correlation of serum leptin with estradiol levels in patients with polycystic ovary syndrome BJMBR
Mendonça,H.C.; Montenegro Junior,R.M.; Foss,M.C.; Silva de Sá,M.F.; Ferriani,R.A..
Patients with polycystic ovary syndrome (PCOS) usually are obese, insulin resistant and hyperinsulinemic. The known association between leptin, obesity andinsulin action suggests that leptin may have a role in PCOS but this has only been addressed peripherally. This study was designed to assess the relationship between serum leptin and the anthropometric, metabolic and endocrine variables of obese (body mass index, BMI ³30 kg/m²) and non-obese (BMI <30 kg/m²) PCOS patients. Twenty-eight PCOS patients and 24 control women subdivided into obese and non-obese groups were evaluated. Leptin, androgens, lipids, gonadotrophins and insulin-glucose response to the oral glucose tolerance test were measured by radioimmunoassay in all participants. The assays were...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Leptin; Polycystic ovary syndrome; Insulin; Insulin sensitivity; Estrogen.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004000500015
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Productive and reproductive parameters in high and low growing Syrian Awassi lambs Animal Sciences
Zarkawi, Moutaz; Al-Daker, Moutassem Billah.
The objective of this study was characterize some productive and reproductive parameters in Syrian Awassi ewe lambs during different age stages. Thirty Syrian Awassi ewe lambs aged around 3 months were divided equally into 2 groups, high and low growing to identify productive and reproductive parameters during different stages. Blood samples were collected to determine progesterone and leptin concentrations. Daily milk samples were collected to determine the average daily production. At puberty, average body weight of higher growing was higher (48.4 kg) than de crescimento low growing (42.8 kg). Average age at puberty was 359.5 and 394.9 days for high and low groups, respectively with no differences. Mating, lambing and fecundity rates were similar among...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Awassi ewe lambs; Productive and reproductive parameters; Progesterone; Leptin; Milk production. leptin; Milk production; Progesterone; Puberty..
Ano: 2018 URL: http://periodicos.uem.br/ojs/index.php/ActaSciAnimSci/article/view/37983
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Protective effect of citrus lemon on inflammation and adipokine levels in acrylamide-induced oxidative stress in rats BJPS
Haidari,Fatemeh; Mohammadshahi,Majid; Zarei,Mehdi; Fathi,Mojdeh.
The high exposure to acrylamide (AA) due to smoking and increased consumption of processed and fast foods in recent years, has become one of the health threatening problems. This study examined the effect of lemon juice on inflammation and adipokines in acrylamide-induced oxidative stress in rats. Forty animals were divided into five groups. Toxicity was induced by AA (35mg/kg) for two weeks in all groups except normal control group. After that, lemon juice in three doses was administrated to treatment groups for 4 weeks. Serum levels of adipokines and inflammatory parameters and both serum and liver levels of oxidative stress parameters were measured. The results showed groups were received AA had significant higher levels of malondialdehyde, tumor...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Citrus lemon; Acrylamide; Inflammation; Leptin; Adiponectin.
Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502019000100606
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Role of sympathetic nervous system and neuropeptides in obesity hypertension BJMBR
Hall,J.E.; Brands,M.W.; Hildebrandt,D.A.; Kuo,J.; Fitzgerald,S..
Obesity is the most common cause of human essential hypertension in most industrialized countries. Although the precise mechanisms of obesity hypertension are not fully understood, considerable evidence suggests that excess renal sodium reabsorption and a hypertensive shift of pressure natriuresis play a major role. Sympathetic activation appears to mediate at least part of the obesity-induced sodium retention and hypertension since adrenergic blockade or renal denervation markedly attenuates these changes. Recent observations suggest that leptin and its multiple interactions with neuropeptides in the hypothalamus may link excess weight gain with increased sympathetic activity. Leptin is produced mainly in adipocytes and is believed to regulate energy...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Obesity; Leptin; Angiotensin; Kidney; Sodium excretion.
Ano: 2000 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000600001
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